Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length

Chełchowska, Magdalena; Ambroszkiewicz, Jadwiga; Gajewska, Joanna; Jabłońska-Głąb, Ewa; Maciejewski, T.; Ołtarzewski, Mariusz

doi:10.1007/s12011-016-0621-7

Cited by 14 publications

(18 citation statements)

References 48 publications

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“…However, in postmenopausal women, the concentration of hepcidin increased [ 28 ]. In healthy pregnant women, concentrations of this hormone decreased gradually in the course of pregnancy to maximize iron absorption and availability, thus enhancing transfer to the fetus [ 8 , 29 ]. There was no correlation between hepcidin in mothers and children, which may suggest that neonatal hepcidin is probably regulated independently of maternal hepcidin concentrations [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

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Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet

Ambroszkiewicz¹,

Klemarczyk²,

Mazur³

et al. 2017

Biol Trace Elem Res

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The aim of this study was to assess the effect of vegetarian diet on iron metabolism parameters paying special attention to serum hepcidin and soluble transferrin receptor (sTfR) concentrations in 43 prepubertal children (age range 4.5–9.0 years) on vegetarian and in 46 children on omnivorous diets. There were no significant differences according to age, weight, height, and body mass index (BMI) between vegetarian and omnivorous children. Vegetarians had similar intake of iron and vitamin B12 and a significantly higher intake of vitamin C (p < 0.05) compared with non-vegetarians. Hematologic parameters and serum iron concentrations were within the reference range in both groups of children. Serum transferrin levels were similar in all subjects; however, ferritin concentrations were significantly (p < 0.01) lower in vegetarians than in omnivores. In children on a vegetarian diet, median hepcidin levels were lower (p < 0.05) but sTfR concentrations significantly higher (p < 0.001) compared with omnivorous children. In the multivariate regression model, we observed associations between hepcidin level and ferritin concentration (β = 0.241, p = 0.05) in the whole group of children as well as between hepcidin concentration and CRP level (β = 0.419, p = 0.047) in vegetarians. We did not find significant associations with concentration of sTfR and selected biochemical, anthropometric, and dietary parameters in any of the studied groups of children. As hematologic parameters and iron concentrations in vegetarians and omnivores were comparable and ferritin level was lower in vegetarians, we suggest that inclusion of novel markers, in particular sTfR (not cofounded by inflammation) and hepcidin, can better detect subclinical iron deficiency in children following vegetarian diets.

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Section: Discussionmentioning

confidence: 99%

“…Production of hepcidin is induced by iron overload and inflammation. Gene expression of this hormone is downregulated by anemia, hypoxia, erythropoietic activity, and iron deficiency [ 5 , 7 , 8 ] .…”

Section: Introductionmentioning

confidence: 99%

Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet

Ambroszkiewicz¹,

Klemarczyk²,

Mazur³

et al. 2017

Biol Trace Elem Res

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“…As a potential biological mechanism, it has been suggested that smoking may stimulate erythropoiesis in a dose-related manner due to hypoxia, which is induced by smoking. In addition, hypoxia is likely to suppress hepcidin expression [8919202122]. …”

Section: Discussionmentioning

confidence: 99%

“…One study reported no difference in plasma iron levels between non-smokers and smokers [8]. But, another study examined that pregnant women who had smoked had higher ferritin levels in blood than those who had never smoked [9]. This discrepancy may be due to the use of different iron biomarkers; ferritin and TSAT are better indicators of iron status than iron in serum or plasma.…”

Section: Introductionmentioning

confidence: 99%

Associations between Lifestyle Factors and Iron Overload in Korean Adults

2016

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It has been suggested that iron overload, which indicates the accumulation of iron, generates cellular reactive oxygens and causes peroxide damages to the body. Such oxidative stresses, in a broader context, are also caused by lifestyles such as alcohol consumption and smoking. However, there are limited data on the association between these lifestyle factors and internal iron overload. In present study, we evaluated associations between lifestyle factors, such as smoking status, alcohol consumption, and physical activity, and serum markers of iron overload. In a population-based cross-sectional study including 2,347 Korean men and women aged 49–79 years, we assessed serum transferrin saturation (TSAT) levels and defined iron overload as TSAT levels > 50% for men and > 45% for women. After excluding persons with chronic diseases and iron deficiency, multivariate odds ratio (OR) and its 95% confidence interval (CI) were estimated to evaluate associations between lifestyle factors and iron overload in 1,973 participants. In all participants, we examined a significantly positive association between heavy alcohol consumption (> 30 g/day) and iron overload; heavy drinkers showed 1.6-fold higher OR (95% CI, 1.11–2.36) than non-drinkers. Stratified analysis by sex showed that this association was significant only among men. In addition, we observed a potential association between heavy smoking > 10 cigarettes/day and iron overload (p = 0.07). In stratified analysis by sex, we examined a significant association between smoking and iron overload only among women; former or current smokers had 1.9-fold higher OR (95% CI, 1.01–3.63) than never-smoker. Our findings suggest that heavy alcohol consumption and smoking may worsen iron accumulation in the body.

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“…Antenatal tobacco use and anemia appear to be correlated [ 6 , 7 ], and are important risk factors for poor pregnancy outcomes [ 8 – 11 ]. Biochemically, tobacco use may affect iron metabolism [ 12 ], iron stores [ 13 ], inflammation [ 14 ], and hemoglobin levels [ 6 ]. Behaviorally, tobacco use may act as an appetite suppressant [ 15 – 17 ], and has been linked with lower food intake and household food insecurity [ 18 – 20 ], while tobacco abstinence may increase appetite [ 16 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Antenatal tobacco use and iron deficiency anemia: integrating tobacco control into antenatal care in urban India

et al. 2018

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BackgroundIn India, tobacco use during pregnancy is not routinely addressed during antenatal care. We measured the association between tobacco use and anemia in low-income pregnant women, and identified ways to integrate tobacco cessation into existing antenatal care at primary health centers.MethodsWe conducted an observational study using structured interviews with antenatal care clinic patients (n = 100) about tobacco use, anemia, and risk factors such as consumption of iron rich foods and food insecurity. We performed blood tests for serum cotinine, hemoglobin and ferritin. We conducted in-depth interviews with physicians (n = 5) and auxiliary nurse midwives (n = 5), and focus groups with community health workers (n = 65) to better understand tobacco and anemia control services offered during antenatal care.ResultsWe found that 16% of patients used tobacco, 72% were anemic, 41% had iron deficiency anemia (IDA) and 29% were food insecure. Regression analysis showed that tobacco use (OR = 14.3; 95%CI = 2.6, 77.9) and consumption of green leafy vegetables (OR = 0.6; 95%CI = 0.4, 0.9) were independently associated with IDA, and tobacco use was not associated with consumption of iron-rich foods or household food insecurity. Clinics had a system for screening, treatment and follow-up care for anemic and iron-deficient antenatal patients, but not for tobacco use. Clinicians and community health workers were interested in integrating tobacco screening and cessation services with current maternal care services such as anemia control. Tobacco users wanted help to quit.ConclusionIt would be worthwhile to assess the feasibility of integrating antenatal tobacco screening and cessation services with antenatal care services for anemia control, such as screening and guidance during clinic visits and cessation support during home visits.

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Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length

Cited by 14 publications

References 48 publications

Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet

Serum Hepcidin and Soluble Transferrin Receptor in the Assessment of Iron Metabolism in Children on a Vegetarian Diet

Associations between Lifestyle Factors and Iron Overload in Korean Adults

Antenatal tobacco use and iron deficiency anemia: integrating tobacco control into antenatal care in urban India

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