Hepatotoxicity Secondary to Chemotherapy

Grigorian, Alla; O’Brien, Christopher B.

doi:10.14218/jcth.2014.00011

Cited by 75 publications

(55 citation statements)

References 78 publications

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“…These patients whom suffered previously from chemotherapeutic drugs failures are now getting an important result with the reduced progression of cancer as well as increasing the rate of survival (2). Regardless of this significant progression in chemotherapy drugs for many malignant diseases, the hepatotoxicity stays one of the chief side effects and sometimes become a lifethreatening problem (3).…”

Section: Introductionmentioning

confidence: 99%

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

Al-Jammas¹,

Al-Saraj²

2020

IJVS

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The present study was intended to determine the histological changes induced by Cytarabine drug on the structure of rabbit's livers and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological change represented by infiltration of mononuclear inflammatory cells, epithelioid cell and Kupffer's cells in hepatic tissue. Fibrosis in portal area, congestion of blood vessels as well as hyperplasia of bile canaliculi and coagulative necrosis of hepatocytes were also noticed in other sections. While the group that received protective (800 IU of vitamin E) prior to each Cytarabine injection, showed a considerable histological improvement than the group received Cytarabine alone, as the histological sections of this group showed a nearly normal histological architecture of the liver that represented by normal arrangement of hepatic cords, no fibrosis no congested blood vessels were seen. though distension of hepatic sinusoids and coagulative necrosis of some hepatocytes were still observed. The present study suggested that vitamin E is an effective chemo-protective agent against hepatotoxicity when used as a protective agent prior to Cytarabine drug taken.

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Section: Introductionmentioning

confidence: 99%

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

Al-Jammas¹,

Al-Saraj²

2020

IJVS

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“…The severity varies from an asymptomatic elevation of the liver function test, acute liver failure, or progressive fibrosis that culminates in end-stage liver disease. Several antineoplastic drugs, such as etoposide and vincristine, produce liver toxicity [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic, Antitumor and Toxicological Profile of Passiflora alata Leaf Extract

et al. 2020

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Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.

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“…Although the ratio of neutrophil to lymphocyte in PDA/AM/P-treated group was slightly increased to untreated group in this study, it was 0.34 near the normal range of the ratio. ALT and AST are biochemical parameters for assessing hepatic toxicity 42 . BUN and creatinine have been used as markers of renal toxicity 43 .…”

Section: Discussionmentioning

confidence: 99%

Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

Kim

et al. 2019

Acta Pharmaceutica Sinica B

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The safety of nanomaterials, a crucial consideration for clinical translation, is enhanced by using building blocks that are biologically nontoxic. Here, we used poly( γ -glutamic acid) ( γ -PGA) and dopamine as building blocks of polymeric nanomaterials for carrying hydrophobic anticancer drugs. The introduction of phenylalanine onto γ -PGA enabled the resulting amphiphilic derivative of γ -PGA acid to self-assemble in the presence of the anticancer drug paclitaxel (PTX) to form PTX-encapsulated micelles. The surfaces of PTX-loaded micelles were then coated with polymerized dopamine (PDA). The PDA-coated, amphiphilic γ -PGA-based micelles (AM) carrying PTX (PDA/AM/P) exerted near-infrared-responsive photothermal effects. Near-infrared irradiation of cancer cells treated with PDA/AM/P nanoparticles produced a greater anticancer effect than that observed in other treatment groups, indicating a synergistic effect. Intravenous administration of PDA/AM/P completely ablated tumors and prevented their recurrence. Notably, the in vivo safety profile of PDA/AM/P nanoparticles allowed PTX to be delivered at a 3.6-fold higher dose than was possible with PTX solubilized in surfactant, and circumvented the side effects of the surfactant. These results support the multifunctional potential of PDA/AM for the delivery of various hydrophobic drugs and imaging dyes for safe translation of nanomaterials into the clinic.

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Hepatotoxicity Secondary to Chemotherapy

Cited by 75 publications

References 78 publications

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

The histological changes induced by Cytarabine on rabbits livers (with and without vitamin E administration)

Cytotoxic, Antitumor and Toxicological Profile of Passiflora alata Leaf Extract

Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

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