Hepatotoxicity in albino rats exposed ton‐octane andn‐nonane

Abstract

Effects of n-octane and n-nonane (1 ml per kg body weight daily) on hepatic and serum enzymes, which reflect abnormal liver function and concentration of lipid and nucleic acid (serum and liver), were studied after 2 and 7 days intraperitoneal administration to albino rats. Decreased activities of serum acetylcholine esterase and carboxyl esterase were observed, together with an increase in FDP aldolase activity. Significant decrease in the concentration of albumin, total protein, and total and esterified cholesterol in serum have been noted after n-octane and n-nonane administration for 7 days. Also, free cholesterol content of liver was elevated significantly after solvents exposure.

Investigation of volatile biomarkers in liver cancer blood using solid‐phase microextraction and gas chromatography/mass spectrometry

“…Liver cytochrome P‐450 and free sulfhydryl contents which had protective functions towards liver injury were found to be decreased after octane administration 31. Definite hepatotoxicity caused by octane was identified later 32. Octane was also identified as being high in the breath of cigarette smokers 33, 34.…”

“…31 Definite hepatotoxicity caused by octane was identified later. 32 Octane was also identified as being high in the breath of cigarette smokers. 33,34 Analysis for some breath VOCs such as octane was used to identify characteristic fingerprints of various lung diseases including lung cancer.…”

Evaluation of the Biochemical Stress Response to Chlorpyrifos in Tissues of the Edible Crab Barytelphusa guerini: Withdrawal of Exposure Improves the Nutritional Value

“…CPF-caused induction in the alkaline phosphatase activity in gill and hepatopancreas might be due to the accelerated membrane transport function related to anion-hydroxide exchange across the lipid biomembranes mediated by organotin compounds as suggested by Jaroli and Sharma (2005). Another reason for the increase could be the destruction of smooth endoplasmic reticulum membrane (Khan and Pandya, 1986). Reduction in the alkaline phosphatase activity in nervous tissue and leg muscle can be taken as an index of parenchymal damage, necrosis, and uncoupling of oxidative phosphorylation.…”

In vivo Impact of Monocrotophos on Biochemical Parameters of a Freshwater Fish during Subacute Toxicity and Following Cessation of Exposure to the Insecticide

“…It refl ects an organ-specifi c response related to the liver's function in determining the exposure route, distribution, and bioaccumulation of pollutants, as well as the defensive capacity (Ahmad et al, 2006). Elevation in the alkaline phosphatase activity of gill, kidney, and muscle tissues might be due to the accelerated membrane transport function related to hydroxy ion exchange across the lipid biomembranes (Jaroli and Sharma, 2005) and also due to the destruction of the smooth endoplasmic reticulum (Khan and Pandya, 1985). Transaminases play an important role in the utilization of amino acids for oxidation and/or gluconeogenesis (Samsonova et al, 2005).…”