Hepatotoxicity and Nephrotoxicity induced by fipronil and lead acetate and their mixture as well as evaluation of therapeutic effects of camel milk against their harmful.

Abstract

Elevated environmental pollution of lead and fipronil blamed for chronic toxicity. Fipronil and lead acetate are commonly used but now no adequate data available concerning side harmful of their mixture. The present work studied the curative effects of camel milk against lead and fipronil toxicity individually and their mixture. The lead acetate or fipronil and their mixture significantly induction deteriorated kidneys and liver function parameters as well as lipid profile and oxidative stress in the both organs. Serum LDH activity increased under the same conditions. Histological examination revealed hepatic degeneration, nephropathy in intoxicated rats relative to normal health control. Both toxicants in their mixture showed more harmful than those of its individual ones. Camel milk treatments into intoxicated animals (lead, fipronil and mixture groups) attenuated the all evaluated parameters, also alleviated the harmful influences of the mixture of lead acetate and fipronil and improved the biomarkers of their oxidative stress.

Prospective nutritional, therapeutic, and dietary benefits of camel milk making it a viable option for human consumption: Current state of scientific knowledge

“…In lead acetate-poisoned rats, camel milk restored hepatic enzyme function (Hailu et al 2016;Ahamad et al 2017;Abrhaley and Leta 2018). Camel milk protects male albino rats from lead acetate and fipronil's hepatotoxic and nephrotoxic effects (Abdel-Mobdy et al 2023). Al-Asmari et al (2017) observed that camel milk reduced oxidative stress and inflammation to protect and regenerate hepatocyte membranes.…”