Hepatotoxic effect of lead and hepatoprotective effect of <i>Hydrilla verticillata</i> on hepatic transcriptional and physiological response in edible fish <i>Labeo rohita</i>

Prabha, Shashi; Rajkumar, Johanna; Karthik, C.

doi:10.1080/01480545.2020.1815762

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Seabuckthorn (Hippophae rhamnoides) leaf-extract (SLE) supplementation in lead acetate-intoxicated Wistar rats. Worked as a toxicity-protective force against lead (49). For people who live in surroundings where lead toxicity is a risk, Daflon-Enriched foods could be a viable preventative measure.…”

Section: Groupsmentioning

confidence: 99%

Role of T. vulgaris protects DNA damage induced by Lead acetate in Rats

Ghazi¹,

Al-Qaiym²

2023

JoBRC

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Objective: The purpose of this study was to investigate Thymus vulgaris (T.vulgaris) ethanolic extract protective role for lymphocytes viability and prevent DNA damage by long-term exposure to Lead acetate (Pb) via ingestion. Material and method: A number of 24 females adult rats were divided into equal groups; 1st Group, as control, 2nd Group administered with lead acetate 5 mg/kg B.W oral gavage lead acetate for 60 days and 3rd Group treated with lead acetate at dose 5mg/kg B.W and T.vulgaris extract at doses 75mg/kg B.W for 60 days. Result: Results of leukocytes (WBCs) and lymphocyte count revealed a significant (P≤0.05) decrease in the 2nd group and an increase in the 3rd group in comparison to the 1st group. Also the result of Lymphocyte/Neutrophil ratio increased significantly (P≤0.05) in the 2nd and 3rd groups as compared to the 1st group. lymphocytes viability were evaluated using trypan blue, showed statistically (P≤0.05) less viable lymphocytes cells were in the 2nd group and more viable lymphocytes cells were found in the 3rd group when comparing to 1st group. Ingestion of T.vulgaris showed a protective role in preventing DNA damage according to comet assay. Conclusion the ethanolic T.vulgaris polyphenols extracted molecules with their unique chemical molecular structure withstand lead toxicity, could be due to chelate lead activity.

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Section: Groupsmentioning

confidence: 99%

Role of T. vulgaris protects DNA damage induced by Lead acetate in Rats

Ghazi¹,

Al-Qaiym²

2023

JoBRC

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Toxic Effects of Arsenic in Commercially Important Fish Rohu Carp, Labeo rohita of Bangladesh

Rabbane

Kabir²,

Habibullah-Al-Mamun³

et al. 2022

Fishes

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This study was designed to elucidate the effects of arsenic (As) on the morpho-behavior, growth development and molecular mechanisms of a commercially important fish, rohu carp, Labeo rohita, in Bangladesh. Fish fry with an average weight of 387.5 ± 169.25 mg and an average length of 3.35 ± 0.37 cm were collected from a local hatchery in Mymensingh, Bangladesh and acclimatized for a week in the Department of Fisheries, University of Dhaka before starting the exposure with arsenic. Fishes were exposed for a period of 14 days with three treatments of NaAsO2, namely treatment 1(T1)—2.5 mg/L; treatment 2 (T2)—15 mg/L; and treatment 3 (T3)—30 mg/L, along with a control (C)—0.0 mg/L, with three replicates. These concentrations were determined based on the LC50 value for 96 h measured for this experiment. This study revealed remarkable morphological abnormalities and deformities in arsenic-exposed rohu carp. In fish exposed to 30 mg/L, caudal fin erosion was a frequent deformity. There was no significant difference in RNA:DNA ratio among the treatments. The overall weight of fish was decreased as the concentration of arsenic was increased. The T3 fish had a statistically significant negative weight gain (−0.05 ± 0.07 g), but the other treatments (T1 and T2) and control fish had no significant weight gain. Different types of histopathological changes were observed in the gills and intestines of arsenic-treated fish. Necrosis and severe damages were found in the secondary lamellae of gills at the highest arsenic concentration (30 mg/L). Epithelial lifting, irregular shape and damages in the gill raker were also observed in the primary lamellae of the gills for the same treatment. In this study, the expression of heat shock protein (HSP 60) and metallothionein (MT) genes was assessed by qPCR, and these genes were upregulated in different treatments compared to controls. The findings of the present study suggest that arsenic pollution significantly changes the morphology, behavior, growth, development, histopathology and molecular mechanisms of this economically important fish, rohu carp, in Bangladesh.

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Hepatotoxic effect of lead and hepatoprotective effect of Hydrilla verticillata on hepatic transcriptional and physiological response in edible fish Labeo rohita

Cited by 2 publications

References 21 publications

Role of T. vulgaris protects DNA damage induced by Lead acetate in Rats

Role of T. vulgaris protects DNA damage induced by Lead acetate in Rats

Toxic Effects of Arsenic in Commercially Important Fish Rohu Carp, Labeo rohita of Bangladesh

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