Hepatotoxic and Cardiotoxic Effects of Testosterone Enanthate Abuse on Adult Male Albino Rats

Experimental studies on androgen administration in animal models: current and future perspectives

“…In light of these considerations, further studies should be performed on animal models, programming special experimental models with the contemporary use of different drugs. As reported by El-Gendy et al [22 ▪ ], the toxic effects at the liver level may be considered reversible after treatment cessation in humans [58]. Undoubtedly, a research field that remains to be further explored is related to miRNA influence in the modulation of adverse effects related to androgen exposure: only Ghanbari-Abarghooi et al [24 ▪ ], investigating the role of miR-122 , confirmed the hypothesis that miRNA dysregulation could play a pivotal role and may be considered a new important tool in the identification of androgen adverse effects [59].…”

“…Carteri et al [14] confirmed the cardiotoxicity of androgen exposure, particularly acting on mitochondrial functionality and on redox homeostasis. El-Gendy et al [22 ▪ ] confirmed these findings, describing toxic effects on rat cardiac muscle in the form of an alteration of normal histology, hypertrophy and fibrosis at both histological and biochemical levels. Nevertheless, the authors concluded that the adverse effects seemed to be reversible after cessation of the treatment.…”

“…El-Gendy et al [22 ▪ ] reported toxic effects at the liver level, demonstrating histological and biochemical changes, despite these being reversible after treatment cessation.…”