A study to demonstrate the potential of Anabolic Androgen Steroid to activate oxidative tissue damage, nephrotoxicity and decline endogenous antioxidant system in renal tissue of Adult Wistar Rats

Memudu, Adejoke Elizabeth; Dongo, Gambo A

doi:10.1016/j.toxrep.2023.02.010

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T-AOC can accurately reflect the antioxidant capacity of both enzymatic and non-enzymatic defense systems, while SOD and CAT represent antioxidant enzyme systems, which are the first lines of defense against free radical damage and reflect the antioxidant capability of the organisms [25,35]. MDA is a byproduct of lipid peroxidation, which represents lipid oxidation and tissue oxidative damage [36]. In the present study, M. salmoides fed with fermented feed significantly increased the antioxidant capability, suggesting that Lactobacillus can efficiently eliminate excess free radicals and improve the antioxidant capacity of M. salmoides.…”

Section: Discussionmentioning

confidence: 99%

Effects of Co-Fermented Feed Using Lactobacillus acidophilus, Limosilactobacillus reuteri and Lactiplantibacillus plantarum on Growth, Antioxidant Capacity, Fatty Acids and Gut Microbiota of Largemouth Bass (Micropterus salmoides)

Yang,

Liu,

Kong

et al. 2023

Fishes

View full text Add to dashboard Cite

The effects of diets fermented with compound probiotics, namely Lactobacillus acidophilus, Limosilactobacillus reuteri and Lactiplantibacillus plantarum, on the growth performance, physiological and biochemical indexes, fatty acid composition and intestinal health of juvenile largemouth bass (Micropterus salmoides) were investigated. Three hundred healthy juvenile M. salmoides (5.29 ± 0.02 g) were selected and randomly divided into two groups with triplicates for each. The basic diet was set as the control group (CON), and fermentation of the basic diet with a mixed bacterial solution (1.8 × 109 cfu/mL, L. acidophilus:L. reuteri:L. plantarum = 1:1:1) was set as the fermentation group (FER). Fish were hand fed to satiation for 56 days and two-thirds of the culture water was renewed every 3 days. The results showed that feed intake of fish in the FER group was significantly lowered, thereby increasing feed efficiency (FE) and protein efficiency (PER) (p < 0.05). Serum alanine aminotransferase (ALT) activity was significantly decreased, and catalase (CAT) activity was significantly increased in the FER group (p < 0.05). The liver superoxide dismutase activity (SOD) was significantly enhanced, and intestinal trypsin was significantly increased in the FER group (p < 0.05). Being fed with the fermentation diet significantly increased the content of n-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA) and the n-3/n-6 PUFAs ratios in the liver (p < 0.05). Intestinal histology showed that villus height and width of the intestine and the number of goblet cells were significantly increased in the FER group (p < 0.05). Those fed with fermentation diets had limited diversity of gut microbiota. Compared to the CON group, the relative abundance of Aeromonas decreased significantly (p < 0.05), while the relative abundance of Fusobacteria, Cetobacteria and Lactobacillusis in FER increased greatly in the gut microbiota of the FER group. In conclusion, fermented feed with the three probiotics effectively improved the feed utilization and antioxidant capacity, promoted digestion and absorption of dietary protein, improved the ability of synthesize DHA and n-3 PUFAs in the liver and reduced the abundance of pathogenic bacteria in the gut. Therefore, the present research provided a new way of co-fermented feed with three probiotics for the aquaculture of M. salmoides.

show abstract

Section: Discussionmentioning

confidence: 99%