Hepatorenal Protective Effects of Pomegranate (Punica granatum) Juice against Nicotine Induced Toxicity in Guinea Pigs

Albasha, Mohamed Omar; Azab, Azab Elsayed

doi:10.9734/jabb/2016/21996

Cited by 5 publications

(3 citation statements)

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“…The present biochemical results showing that coadministration of pomegranate peel extract to animals treated with Cd significantly decreased the serum urea, creatinine and BNU compared with Cd treated group. This is in agreement with Albasha and Azab (2016) who found that co-treatment of aqueous extract of pomegranate (Punica granatum) to nicotine treated male Guinea pigs diminished these parameters. Sadeghi et al, (2015) reported that 25 mg/kg pomegranate flower extract decreased the serum levels of creatinine and blood urea nitrogen after gentamicin treatment.…”

Section: Discussionsupporting

confidence: 93%

Pomegranate peel Extract Protects Cadmium-induced nephrotoxicity in albino mice.

El-Daly

2016

Journal of Bioscience and Applied Research

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Cadmium chloride (CdCl 2) is a toxicant heavy metal displays adverse properties in humans creating public health risks. Pomegranate (Punica granatum L.) is widely known as antimicrobial and antioxidant. This study investigated the cadmium induced structural effects in mice and evaluated the beneficial effect of alcoholic extract of P. granatum fruit peel (PPE) to protective CdCl 2 nephrotoxicity. Animals were divided into 4 groups; group 1: control, group 2: given 25ml/kg PPE, group 3: given CdCl 2 at a dose level of 2mg/kg and group 4: given CdCl 2 and PPE. The animals were given the previous treatment daily for 14days. CdCl 2 intoxication led to obvious many histopathological alterations in kidney glomeruli accompanied with wide and congested blood vessels, renal tubules missed their distinct form with cytoplasmic vacuolation of their epithelial cells and pyknotic nuclei and leucocytes cells infiltration in the intertubular spaces. On the other hand, the immunohistochemical staining of antiapoptotic Bcl-2 and α-smooth muscle actin (α-SMA) expressions were positive after CdCl 2 exposure compared with the control group. Ultrastructure observations revealed thickening of the glomerular basement membrane and fusion of the podocytes foot processes, tubular epithelial cells vacoulation with pyknotic nuclei, perforation and vacoulation of mitochondria, deterioration of endoplasmic reticulum, and increase of lysosomes. CdCl 2-exposure accompanied by increased level of serum urea, creatinine and blood urea nitrogen (BUN) as well as significant increase in malondialdehyde (MDA) besides decreased of the total antioxidant capacity (TAC) level. In contrast, coadministration of PPE plus CdCl 2 ameliorated these parameters around the normal levels. It contributed the improvement by the histological, ultrastructure and decreased Bcl-2 and α smooth muscle protein expression, and kidney function through significant decrease in urea, creatinine and BUN, reduced the level of serum MDA as lipid peroxidation marker and restored the altered antioxidant system activity. It was concluded that Cd induced nephrotoxicity at a dose level 2 mg/kg b.w. in mice. The PPE may be involved in the protection of toxicity displayed by CdCl 2 induction attributed to the high antioxidant capacity.

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Section: Discussionsupporting

confidence: 93%

Pomegranate peel Extract Protects Cadmium-induced nephrotoxicity in albino mice.

El-Daly

2016

Journal of Bioscience and Applied Research

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“…Furthermore, another mechanism may be through anti-inflammatory and different signaling pathways [120]. In addition, Albasha and Azab, [123] found that In nicotine-treated Guinea pigs, the serum urea, uric acid, creatinine, and potassium ions concentrations were significantly (p < 0.05), increased and sodium ions concentrations were significantly decreased as compared to the control group. Pomegranate juice administration showed a remarkable amelioration of these abnormalities in nicotine-treated male Guinea pigs.…”

Section: Pomegranate (Punica Granatum L)mentioning

confidence: 99%

“…Punicalagins and ellagic acid are also responsible for the antioxidant activity and health benefits of pomegranates [126]. Pomegranate contains tannins, phenols, and flavonoids which can directly or indirectly reduce oxidative damage by preventing the excessive generation of free radicals [123] [127].…”

Section: Pomegranate (Punica Granatum L)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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