Hepatoprotective triterpenes from the gum resin of Boswellia carterii

Wang, Yan-Gai; Ma, Qinge; Tian, Jin; Ren, Jin; Wang, Aiguo; Ji, Tengfei; Yang, Jun; Su, Ya‐Lun

doi:10.1016/j.fitote.2015.12.018

Cited by 28 publications

(9 citation statements)

References 27 publications

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“…The nine known compounds were identified as populeuphroid L ( 5 ) [7], epimansumbinol ( 6 ) [12], ergosta-4,6,8(15),22-tetraen-3-one ( 7 ) [15], mansumbin-13(17)-en-3,16-dione ( 8 ) [16], 3 α -acetoxy-mansumbin-13(17)-en-16-one ( 9 ) [17], 3-epi-δ-amyrin ( 10 ) [18], α-boswellic acid ( 11 ) [19], 11α-ethoxy-β-boswellic acid ( 12 ) [20], acetyl-11-keto-β-boswellic acid ( 13 ) [21] by a comparison of their spectroscopic data with those reported in the literature. Although compound 12 is a known one, it might be an artefact produced during extraction procedure.…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

et al. 2019

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Two new octanorlanostane-type triterpenes, euphraticanoids A and B (1 and 2), two new trinorsesquiterpenoids, euphraticanoids C and D (3 and 4), and eight known triterpenoids (5, 6, 8–13) along with one steroid (7) were isolated from Populus euphratica resins. The structures of these new compounds, including their absolute configurations, were characterized by spectrocsopic, chemical, and computational methods. Biological evaluation revealed that compounds 4, 7–9, 12, and 13 display neuroprotective activities in H2O2-induced HT-22 cells with 4, 8, and 9 occurring in a concentration-dependent manner and 7, 12, and 13 reaching the maximum effects at 20 μM. Meanwhile, the neuroprotective properties of all isolates were accessed using glutamate-induced SH-SY5Y cells and disclosed that compounds 3, 4, 8, and 9 could dose-dependently protect neural cell injury in a concentration range of 10–40 μM. Finally, a brief structure–activity relationship was briefly discussed.

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Section: Resultsmentioning

confidence: 99%

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

et al. 2019

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“…Overall, the phytochemical analyses revealed that the extract contained mainly saponins and triterpenes. Generally, the presence of phenolic-based compounds, saponins, and triterpenes were believed to contribute synergistically to the observed antioxidant and hepatoprotective activities of AQDL [68][69][70].…”

Section: Discussionmentioning

confidence: 99%

Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol

et al. 2019

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This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg), were administered orally to rats (n = 6) once daily for seven consecutive days followed by the hepatotoxicity induction using 3 g/kg PCM (p.o.). Blood was collected for serum biochemical parameters analysis while the liver was collected for histopathological examination and endogenous antioxidant enzymes analysis. AQDL was also subjected to antioxidant determination and phytochemical analysis. Results obtained show that AQDL possessed high total phenolic content (TPC) value and remarkable radical scavenging activities. AQDL also significantly (p < 0.05) reduced the liver weight/body weight (LW/BW) ratio or serum level of ALT, AST, and total bilirubin while significantly (p < 0.05) increase the level of superoxide dismutase (SOD) and catalase (CAT) without affecting the malondialdehyde (MDA) in the liver indicating its hepatoprotective effect. Phytoconstituents analyses showed only the presence of saponins and triterpenes, but lack of flavonoids. In conclusion, AQDL exerts hepatoprotective activity via its high antioxidant potential and ability to modulate the endogenous enzymatic antioxidant defense system possibly via the synergistic action of saponins and triterpenes.

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“…The compounds of B. carterii showed a liver protective effect by inhibiting damage from D-galactosamine to HL-7702 cells [ 4 , 19 , 24 ].…”

Section: Pharmacologymentioning

confidence: 99%

Review of the Chemical Composition, Pharmacological Effects, Pharmacokinetics, and Quality Control of Boswellia carterii

Huang

Chen

Liang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. This review aimed to systematically summarize studies that investigated the bioactivities of compounds and extracts from Boswellia. Methods. A literature review on the pharmacological properties and phytochemicals of B. carterii was performed. The information was retrieved from secondary databases such as PubMed, Chemical Abstracts Services (SciFinder), Google Scholar, and ScienceDirect. Results. The various Boswellia extracts and compounds demonstrated pharmacological properties, such as anti-inflammatory, antitumour, and antioxidant activities. B. carterii exhibited a positive effect on the treatment and prevention of many ageing diseases, such as diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Conclusion. Here, we highlight the pharmacological properties and phytochemicals of B. carterii and propose further evidence-based research on plant-derived remedies and compounds.

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Hepatoprotective triterpenes from the gum resin of Boswellia carterii

Cited by 28 publications

References 27 publications

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins

Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol

Review of the Chemical Composition, Pharmacological Effects, Pharmacokinetics, and Quality Control of Boswellia carterii

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