Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol

Abstract

This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg), were administered orally to rats (n = 6) once daily for seven consecutive days followed by the hepatotoxicity induction using 3 g/kg PCM (p.o.). Blood was collected for serum biochemical parameters analysis while the liver was collected for histopathological examination and endogenous antioxidant enzymes analysis. AQDL was also subjected to antioxidant determination and phytochemical analysis. Results obtained show that AQDL possessed high total phenolic content (TPC) value and remarkable radical scavenging activities. AQDL also significantly (p < 0.05) reduced the liver weight/body weight (LW/BW) ratio or serum level of ALT, AST, and total bilirubin while significantly (p < 0.05) increase the level of superoxide dismutase (SOD) and catalase (CAT) without affecting the malondialdehyde (MDA) in the liver indicating its hepatoprotective effect. Phytoconstituents analyses showed only the presence of saponins and triterpenes, but lack of flavonoids. In conclusion, AQDL exerts hepatoprotective activity via its high antioxidant potential and ability to modulate the endogenous enzymatic antioxidant defense system possibly via the synergistic action of saponins and triterpenes.

The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy in streptozotocin-induced Sprague–Dawley rats

“…A similar value of DT 400 of the sodium level with NS and a decrease in chloride content in serum prove that lutein can balance serum electrolytes ( Sindhu and Kuttan, 2013 ) in diabetes-induced rats. An abnormal increase in ALP is a direct reflection of the increase in ROW in kidney and kidney dysfunction in diabetics as amino acids are converted into ketoacids in hyperglycemic conditions ( Zakaria et al, 2019 ; Konda et al, 2019 ). In such a case, lutein content in PSPL suppresses the excessive stimulation of protein catabolism ( Mrowicka et al, 2022 ) and represses gluconeogenesis through the Sirtuin 1 pathway ( Hwang et al, 2018 ; Zang et al, 2018 ).…”

Natural Honey (Raw Honey): Insights on Quality, Composition, Economic and Health Effects: A Comprehensive Review

“…Honey and quercetin extract were shown to reduce insulin resistance and increase insulin levels in this research. The expression of Akt was enhanced by honey treatment, but IRS-1 serine phosphorylation, nuclear factor-kappa B, and mitogen-activated protein kinase expression were decreased [90].…”

“…Fructose also exhibits a unique hypoglycemic effect in the liver, allowing it to control glucose levels. In this mechanism of action, fructose promotes hepatic glucose phosphorylation [90] by activating phosphorylation enzymes like glucokinase. Glycogenolysis is slowed or stopped when these enzymes are blocked.…”

Dicranopteris linearisA potential medicinal plant with anticancer properties

“…Phytochemical screening of D. linearis leaves have been mainly done by using the dried powdered form and extracts form of different solvents. Based on previous studies, D. linearis in dried powder form and extracts form of aqueous, chloroform and methanol revealed the presence of flavonoids, saponins, tannins, steroids, and triterpenes (Zakaria et al, 2006;Zakaria et al, 2008;Zakaria et al, 2011;Rodzi et al, 2013;Kamisan et al, 2014), with the aqueous extract contained mainly saponins and triterpenes (Zakaria et al, 2019).…”