Hepatoprotective Role of Ethanolic Extract of<i>Vitex negundo</i>in Thioacetamide-Induced Liver Fibrosis in Male Rats

Kadir, Farkaad A.; Kassim, Normadiah M.; Abdulla, Mahmood Ameen; Yehye, Wageeh A.

doi:10.1155/2013/739850

Cited by 46 publications

(20 citation statements)

References 29 publications

(34 reference statements)

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“…Figure 1(b) is the same as Figure 1, TAA, in another article by the same group, Amin et al [2], and Figures 1(f) and 1(g) in [1] are the same.…”

mentioning

confidence: 63%

“…In the article titled “Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats” [1], there was figure duplication in Figure 1, which showed the appearance of livers. Figure 1(b) is the same as Figure 1, TAA, in another article by the same group, Amin et al [2], and Figures 1(f) and 1(g) in [1] are the same.…”

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confidence: 99%

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Corrigendum to “Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide‐Induced Liver Fibrosis in Male Rats”

Kadir

Kassim

Abdulla

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Figure 1(b) is the same as Figure 1, TAA, in another article by the same group, Amin et al [2], and Figures 1(f) and 1(g) in [1] are the same.…”

mentioning

confidence: 63%

mentioning

confidence: 99%

Corrigendum to “Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide‐Induced Liver Fibrosis in Male Rats”

Kadir

Kassim

Abdulla

et al. 2018

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…[47] Moreover, the observed alterations in serum AST, ALT, ALP, CK, and LDH activity and total bilirubin levels are good indicators for hepatic injury resulting from cellular leakage and the loss in functional integrity of the cell membrane in liver. [48] Cellular damages are identified by increases in serum ALP, ALT, and AST levels in that these enzymes are in the cytoplasm and after cellular damage, enters blood circulation. [49] This is due to the increased permeability of the plasma membrane or cellular necrosis leading to leakage of the enzymes into the blood stream.…”

Section: Discussionmentioning

confidence: 99%

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Hassan¹,

Serag²,

Abdel-Hamid³

et al. 2015

Hepatoma Res

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Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4 months. These groups consisted of the control group, a group receiving thioacetamide (TAA) (200 mg/kg b.w) in drinking water, a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w) in addition to TAA for 4 months, a group receiving oral doses of IN (10 mg/kg b.w) in addition to TAA for 4 months, and a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w) and IN (10 mg/kg b.w) plus TAA for 4 months. Results: The current data exhibited increment of serum and liver enzyme ( alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatine kinase, and lactate dehydrogenase) activity, serum lipid profi le levels (total lipids, total cholesterol, triglycerides, low-density lipoprotein, and very low-density lipoprotein), and a signifi cant increase in α-fetoprotein and bilirubin, accompanied with reduced total serum protein and albumin levels in a HCC rat model. Histopathologically, numerous alterations were detected in hepatic tissues of HCC rats, such as lymphocytic cell infi ltration, damage of hepatocytes, dilated congested central vein with degenerated endothelial cells, and congested blood sinusoids in addition to Masson's trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi brosis. Treatment of HCC rats with CIS or IN improved such deleterious effects, where IN is more effective than CIS, and the best effect can be observed in rats that received both CIS and IN. Conclusion: It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model. Key words: Chicory; cisplatin; hepatocellular carcinoma; inulin INTRODUCTIONCancer is one of the most anxiety-inducing diseases and it is presenting with further prolongation and increasing occurrence.[1] The most common and recurrent primary malignancy of the liver is recognized as hepatocellular carcinoma (HCC), a major malignancy worldwide and is increasingly associated with cancer-related death.[2] HCC represents the most common primary malignancy of the liver. According to epidemiological surveys, the prevalence Synergistic curative effect of chicory extract and cisplatin Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma against thioacetamide-induced hepatocellular carcinoma This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the ...

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“…Significant anti-fungal [6] and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa has been reported [7]. Alcoholic extract of the seeds is reported for hepatoprotective activity against CCl 4 [8], leaves against anti-tubercular drugs and thioacetamide induced hepatotoxicity [9,10].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents

Sharma¹,

Suri²,

Ch³

et al. 2016

Biochem Anal Biochem

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The use of Vitex negundo Linn. (Family: verbenaceae) is well documented in ayurveda and traditional Indian system of medicine for variety of diseases and liver ailments. The aim of the study was to investigate liver protective efficacy of a standardized bioactive fraction (SF) from Vitex negundo Linn. against acetaminophen (APAP) and galactosamine (GalN) hepatotoxicity. SF was tested at doses 12.5, 25, 50 and 100mg/kg, p.o. using both prophylactic and curative treatment schedule against APAP and GalN hepatotoxicity in mice and rats respectively. Isolated markers agnuside and negundoside were tested against APAP toxicity. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and albumin were estimated in serum and triglycerides (TG), total protein, glutathione (GSH) and lipid peroxidation (LP) in liver homogenate. Histopathological studies were carried out against APAP induced hepatotoxicity. SF exhibited significant hepatoprotection against APAP and GalN evident by restoration of ALT, AST, LDH, ALP, bilirubin, TG, albumin and total protein. Levels of LP and GSH also exhibited significant dose dependent recovery when treated with SF. Agnuside and negundoside also exhibited dose dependent protection against APAP induced hepatotoxicity. Microscopic examination of histopathological sections of liver confirmed hepatoprotective potential of SF. Results of the study suggest significant value of SF as hepatoprotective with sufficient safety margin as no mortality and change in general gross behavior was observed up to 2000 mg/kg, p.o. Hepatoprotective mechanism of SF may be due to its antioxidant activity exhibited by protection against increased lipid peroxidation and maintained glutathione status. It is apparent from the present study that agnuside and negundoside are the active ingredients in SF and can be responsible for the activity of SF.

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Hepatoprotective Role of Ethanolic Extract ofVitex negundoin Thioacetamide-Induced Liver Fibrosis in Male Rats

Cited by 46 publications

References 29 publications

Corrigendum to “Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide‐Induced Liver Fibrosis in Male Rats”

Corrigendum to “Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide‐Induced Liver Fibrosis in Male Rats”

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

Protective Effect of a Standardized Fraction from Vitex negundo Linn. Against Acetaminophen and Galactosamine Induced Hepatotoxicity in Rodents

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