Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats

Yuvaraj, P.; Subramoniam, A.

doi:10.1515/jbcpp.2009.20.2.169

Cited by 27 publications

(16 citation statements)

References 6 publications

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“…Ginger extracts were administrated orally at a dose 200 mg/kg) [14]. Silymarin; a reference herbal drug was orally administered at a dose 100 mg/kg [24]. …”

Section: Methodsmentioning

confidence: 99%

Zingiber officinale acts as a nutraceutical agent against liver fibrosis

Motawi

Hamed

Shabana³

et al. 2011

Nutr Metab (Lond)

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Background/objectiveZingiber officinale Roscoe (ginger) (Zingiberaceae) has been cultivated for thousands of years both as a spice and for medicinal purposes. Ginger rhizomes successive extracts (petroleum ether, chloroform and ethanol) were examined against liver fibrosis induced by carbon tetrachloride in rats.ResultsThe evaluation was done through measuring antioxidant parameters; glutathione (GSH), total superoxide dismutase (SOD) and malondialdehyde (MDA). Liver marker enzymes; succinate and lactate dehydrogenases (SDH and LDH), glucose-6-phosphatase (G-6-Pase), acid phosphatase (AP), 5'- nucleotidase (5'NT) and liver function enzymes; aspartate and alanine aminotransferases (AST and ALT) as well as cholestatic markers; alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total bilirubin were estimated. Liver histopathological analysis and collagen content were also evaluated. Treatments with the selected extracts significantly increased GSH, SOD, SDH, LDH, G-6-Pase, AP and 5'NT. However, MDA, AST, ALT ALP, GGT and total bilirubin were significantly decreased.ConclusionsExtracts of ginger, particularly the ethanol one resulted in an attractive candidate for the treatment of liver fibrosis induced by CCl4. Further studies are required in order to identify the molecules responsible of the pharmacological activity.

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“…Ginger extracts were administrated orally at a dose 200 mg/kg) [14]. Silymarin; a reference herbal drug was orally administered at a dose 100 mg/kg [24]. …”

Section: Methodsmentioning

confidence: 99%

Zingiber officinale acts as a nutraceutical agent against liver fibrosis

Motawi

Hamed

Shabana³

et al. 2011

Nutr Metab (Lond)

View full text Add to dashboard Cite

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“…The Hill Korwa tribe from Chhattisgarh state prepared juice from the leaves to treat neuritis and mad dog bite [34]. Instead of this conventional or traditional knowledge, the work was undergone to exhibit distinctive biological activities of the plant like wound healing [35], memory enhancing [36], hepatoprotective [37], antidiarrheal [38], antioxidant [39], antidiabetic and antihyperlipidemic [40] activities of the plant. Based on the utilization rate by Yanadi tribe, scientific literature on ethnopharmacological data and the prior work on validation of antimicrobial activity of T. populnea are vague.…”

Section: Resultsmentioning

confidence: 99%

Documentation of ethnomedicinal information and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Ganugapenta village, Chittoor District, Andhra Pradesh, India

Savithramma

Yugandhar

Devi

et al. 2017

J Intercult Ethnopharmacol

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Aim:This study aimed to document the traditional knowledge of medicinal plants and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Chittoor district, Andhra Pradesh, India.Materials and Methods:The study was mainly focused on documentation of medicinal plants used by Yanadi tribe to treat different diseases with a standard questionnaire. These plants were cross-checked in Dr. Dukes Database and available literature to know the significance of this tribe on medicinal knowledge. Among the documented plants, T. populnea was selected for antimicrobial activity with disc diffusion assay.Results:Among the documented medicinal plants, herbs were the most utilized plants, followed by leaf part of the plants; paste form of medicinal preparation was the dominant one among the mode of preparations and oral administration was generally followed by this tribe. When checked these plants in Dr. Duke’s Phytochemical and Ethnobotanical Database most of the medicinal plants were matched at least one medicinal use and most of them were correlated with existing literature. In antimicrobial activity, the microbial pathogens Klebsiella pneumonia among bacteria and Rhizopus arrhizus among fungi were most susceptible to methanol extract of T. populnea.Conclusion:From this study, we conclude that the preparation and dosage of the medicines by Yanadi tribe of this area is unique and the correlation of medicinal data with Duke’s Database and existing literature reveals high medicinal significance of claimed data of this tribe and potential inhibitory activity of T. populnea could be studied further to isolate effective antimicrobial agents.

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“…Subgroup IIb was divided into 3 replicates (IIb 1 , IIb 2 , and IIb 3 ) respectively each replicate had 3 rats and received 200 mg/kg, 300 mg/kg or 450 mg/kg of Allium sativum extracts orally daily. The subgroup IIc, three rats each in a cage and replicated thrice received the standard drug silymarin at 100mg/kg [10]. The biochemical parameters superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and malondialdehyde (MDA) assessed were determined first before the start of the experiment and subsequently monthly for the duration of the study.…”

Section: Experimental Designmentioning

confidence: 99%

Antioxidative Effects of Allium Sativum Methanolic Extracts against Paracetamol induced Liver Toxicity

2017

International Journal of Research in Pharmacy and Biosciences

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This study was undertaken to investigate the antioxidative effects of Allium sativum methanolic extracts on paracetamol induced hepatotoxic rats. Fifty-four adult male albino rats comprising of nine normal and forty-five paracetamol hepatotoxic rats were used for the study. The different biochemical parameters assessed were determined before the start of the study and subsequently monthly for the duration of the study. The activities of antioxidant enzymes such as superoxide dismutase SOD, catalase CAT, reduced glutathione GSH as well as the concentration of malondialdehyde as an indicator of lipid peroxidation were measured to evaluate oxidative stress in the experimental rats. Blood samples were collected through the eye of the rats and serum was obtained by centrifugation and stored at -20oC prior to analysis. The effects of increasing dosages (200, 300 and 450mg/kg bw) of Allium sativum methanolic extracts studied produced a duration and dose dependent significant (p < 0.05) rise in superoxide dismutase, a duration and dose dependent significant reduction in malondialdehyde levels but a duration and dose independent significant rise in catalase and reduced glutathione of hepatotoxic rats when compared with those of the paracetamol, normal and silymarin control rats. The result of this experimental study provides sufficient scientific baseline information for the potential use of the methanolic extract of A. sativum as an antioxidant agent in the fight against oxidative stress mediated diseases. It may be concluded that A. sativum extracts may prevent oxidative changes in liver by reducing reactive oxygen species.

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Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats

Cited by 27 publications

References 6 publications

Zingiber officinale acts as a nutraceutical agent against liver fibrosis

Zingiber officinale acts as a nutraceutical agent against liver fibrosis

Documentation of ethnomedicinal information and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Ganugapenta village, Chittoor District, Andhra Pradesh, India

Antioxidative Effects of Allium Sativum Methanolic Extracts against Paracetamol induced Liver Toxicity

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