Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study

Desai, Sudha; Patel, Disha; Devkar, Ranjitsinh; Patel, Prabhudas V.; Ramachandran, A. V.

doi:10.1016/j.fct.2011.10.063

Cited by 60 publications

(43 citation statements)

References 34 publications

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“…MK extract has been reported to be rich in phenolic acids such as tannic acid, gallic acid, caffeic acid, cinnamic acid, chlorogenic acid, ferulic acid, and vanillic acid (Singh et al 2004). A pilot study in our lab had established hepatoprotective potential of MK extract in carbon tetrachloride (CCl4) induced hepatotoxic rat model due to high contents of flavonoids and polyphenols present in the extract (Desai et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells

et al. 2014

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Several lines of evidences have established a lineage between Oxidised LDL (Ox-LDL) to apoptosis of macrophages in which the high level of intracellular cholesterol play a crucial role. This study assesses the potency of Murraya koenigii (MK) leaf extract in alleviating LDL oxidation and Ox-LDL induced lipotoxicity in murine macrophage (RAW 264.7) cells. Results indicated that presence of MK extract prevented oxidation of LDL as evidenced by its oxidation kinetics and formation of LDL oxidation products. Also, MK extract accounted for improvement in cell viability and mitochondrial membrane potential of Ox-LDL treated cells. The Ox-LDL induced increment in intracellular oxidative stress, nuclear condensation and apoptosis was effectively prevented by MK extract possibly due to their established anti-oxidant and free radical scavenging potentials which may be attributed to the presence of flavonoids present in the extract. Prevention of oxidative modification of LDL, free radical induced damage and Ox-LDL induced death of RAW 264.7 cells provide preliminary evidences of its antiatherosclerotic potential and warrants further elucidation and validation for its use in-vivo and may be useful as a functional food supplement and an alternative medicine to prevent LDL oxidation and oxidized LDL induced toxicity.

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Section: Introductionmentioning

confidence: 99%

Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells

et al. 2014

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“…Therefore, CCl 4 , a potent hepatotoxin metabolized by cytochrome P450 to yield toxic intermediate, trichloromethyl radicals which cause increase in hepatic lipid peroxidation and consequently liver damage and oxidative stress (Shah, 1979), was utilized in this study. A multitude of studies suggested that herbal extracts from edible and medicinal plants exhibited strong antioxidant activity that could against CCl 4 -induced liver damage (Desai et al, 2012;Sreelatha et al,. 2009;Yang et al, 2010;Yeh et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Liu

Geng

et al. 2014

Pharmaceutical Biology

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Objective: The present study investigates the hepatoprotective effect of Berchemia lineate ethanol extract (BELE) on CCl 4 -induced acute liver damage in mice. Materials and methods: Effect of BELE administrated for 7 consecutive days was evaluated in mice by the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), albulin (ALB), globulin (GLB), and total protein (TP) levels, as well as liver superoxide dismutase (SOD) activity and malondialdehyde (MDA) level. Moreover, histopathological examinations were also taken. SOD (291.17, 310.32, and 325.67 U/mg prot) and reduction of MDA (7.27, 6.77, and 5.33 nmol/mg prot) levels. Histopathological examinations also confirmed that BELE can ameliorate CCl 4 -induced liver injuries, characterized by extensive hepatocellular degeneration/necrosis, inflammatory cell infiltration, congestion, and sinusoidal dilatation. Discussion and conclusion: The results indicated that BELE possessed remarkable protective effect against acute hepatotoxicity and oxidative injuries induced by CCl 4 , and that the hepatoprotective effects of BELE may be due to both the inhibition of lipid peroxidation and the increase of antioxidant activity.

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“…The histopathological studies of the liver sections of the mice treated with CCl 4 showed severe necrosis, fatty infiltration like ballooning of hepatocytes, fibrosis, lymphocytic infiltration and loss of cellular boundaries (Plate 5). Previous studies revealed that, liver sections of CCl 4 treated rats were characterized by significant intracellular lipid accumulation, formation of ballooning hepatocytes, infiltration of inflammatory cells and hepatocyte necrosis (Jadeja et al, 2011;Desai et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Eclipta alba ameliorates carbon tetrachloride-induced structural and functional changes in liver of mice

Patel¹,

Verma²

2013

J. Exper. Appl. Anim. Sci.

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The aim of the present investigation was to evaluate the ameliorative effect of Eclipta alba extract against carbon tetrachloride (CCl 4 )-induced structural and functional changes in livers of mice. Healthy adult Swiss strain female albino mice were orally administered with CCl 4 (826 mg/kg body weight/day, p.o.) alone and along with Eclipta alba extract (100, 200 and 300 mg/kg body weight/day, p.o.) for 30 days. The degree of protection was determined by measuring histopathological changes and lipid peroxidation in liver as well as activities of ALT, AST, ACP, ALP, LDH, γ-GT enzymes and bilirubin contents in serum of mice. The histopathological studies revealed severe necrosis, fatty infiltration, lymphocytic infiltration and fibrosis in liver of CCl 4 treated mice. In addition, biochemical studies revealed a significant increase in lipid peroxidation. The enzymes activities as well as bilirubin contents in serum were significantly (p<0.05) increased in CCl 4 only treated mice when compared with the control group. However, co-treatment of CCl 4 along with Eclipta alba extract showed significant reductions in activities of enzymes and bilirubin content as compared with CCl 4 alone treated mice. The effects were dose-dependent (r = 0.9826 to 1). Carbon tetrachloride induced lipid peroxidation was significantly (p<0.05) ameliorated in a dose-dependent manner. Histopathological changes were also ameliorated on treatment with Eclipta alba extract. The ameliorative effects of Eclipta alba on CCl 4 -induced hepatotoxicity could be due to its antioxidative property. The extract was found to be safe as evidenced by their high LD 50 value.

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Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study

Cited by 60 publications

References 34 publications

Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells

Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice

Eclipta alba ameliorates carbon tetrachloride-induced structural and functional changes in liver of mice

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Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study

Cited by 60 publications

References 34 publications

Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells

Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells

Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl4-induced acute hepatotoxicity in mice

Eclipta alba ameliorates carbon tetrachloride-induced structural and functional changes in liver of mice

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Hepatoprotective effect of ethanol extract fromBerchemia lineateagainst CCl₄-induced acute hepatotoxicity in mice