Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Bansal, Jharna; Kumar, Nitin; Malviya, Rishabha; Sharma, Pramod Kumar

doi:10.5530/pc.2014.3.2

Cited by 11 publications

(5 citation statements)

References 96 publications

(78 reference statements)

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“…Besides this ejection of bile, the collection, as well as detoxification of various drugs and xenobiotics, proceeds through the liver. The hepatic reticuloendothelial system (RES) clears stimulated clotting factors, proteolytic enzyme/inhibitor complexes, and fibrin–fibrinogen cleavage proceeds (Bansal et al 2014 ). Liver-related diseases are one of the biggest health disorders in the world; the pathogenesis of hepatic ailments as well as the role of oxidative stress inflammation are well accomplished (Malhi and Gores 2008 ; Tacke et al 2009 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytochemistry and pharmacological activity of the genus artemisia

et al. 2021

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Phytochemistry and pharmacological activity of the genus artemisia

et al. 2021

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“…Phyllanthus niruri aids memory enhancement, help to reduce fatigue and possess anti-ageing and anti-stress properties [ 21 ]. Also, Aloe vera , Tephrosia purpurea and Eclipta alba have hepatoprotection, blood cleansing synergy and also help in managing gastrointestinal integrity and heart burn [ 22 ]. Eclipta alba , Aloe vera , Tephrosia purpurea and Phyllanthus niruri together offer hepatoprotection weight loss therapy.…”

Section: Introductionmentioning

confidence: 99%

Five traditional Nigerian Polyherbal remedies protect against high fructose fed, Streptozotocin-induced type 2 diabetes in male Wistar rats

Kale

Akinpelu

Bakare

et al. 2018

BMC Complement Altern Med

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BackgroundThis present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fructose feeding (20%W/V) ad libitum for 2 weeks and streptozotocin (STZ, 40 mg/kg) (15th Day) intraperitoneally.MethodsSeventy-two hours after STZ injection, fourty-eight diabetic rats were divided into eight of 6 rats/group: Diabetic normal untreated, glibenclamide (GBLI, 0.07 mL/kg) or yoyo (YB, 0.43), ruzu (RB, 0.08), fajik (FJB, 0.20), oroki (OB, 0.16), and fidson (FB, 0.43)/ mL/kg bitters respectively. Controls normal and diabetic untreated groups received intragastric carboxylmethylcellulose (CMC, 1 mL/kg) for eleven days.ResultsT2D was characterized in rats by an increased (p < 0.001–0.05) blood glucose levels (BGL), total cholesterol, triglycerides, low-density lipoprotein and alanine aminotransferase compared with control CMC group. Similarly, hepatic and pancreatic malondialdehyde (MDA) were increased by 180 and 97% respectively. Polyherbal treatments demonstrated efficacies on BGL as follow: YB (55.6%, 160.7 mg/dL); RB (59.7%, 145.2 mg/dL); FJB (59.8%, 243.4 mg/dL); OB (60.8%, 194.5 mg/dL) and FB (61.3%, 203.3 mg/dL) respectively by day 11 (versus GBLI, 65.1%) compared with control untreated diabetic rats. Also, elevated TC, LDL cholesterol, ALT were lowered (p < 0.05) by YB, FJB, and FB respectively in rats. YB, FJB, and OB lowered MDA levels in treated rats. Further, YB, RB, FJB and FB restored changes in liver, and pancreas histopathology. Predominant non-polar bioactive include oleic, hexadecanoic, octadecanoic among others following gas chromatography-mass spectrophotometry analyses.ConclusionOverall, these present results demonstrate anti-hyperglycemic potentials, although with cautions, of some polyherbal in T2D rats, which may, in part, be antioxidants mediated.

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“…Vitamins C and E affect liver regeneration through increasing hepatocyte activity, according to the results. [27] Lu reported a metabolomics research in POFS rats caused by PH. The citric acid cycle, branched-chain amino acid metabolism, fatty acid transport and metabolism, phospholipid metabolism, tryptophan metabolism, phenylalanine metabolism, and purine metabolism were all identified as metabolic processes and potential biomarkers associated with POFS.…”

Section: Role Of Vitaminsmentioning

confidence: 99%

Hepatoprotective Potentials of Some Emerging Indian Medicinal Plants

Mukherjee¹

2022

IJMPS

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When more organs are added to the vertebrate system, metabolites such as bile are generated, as well as glycogen, which is then detoxified and liver proteins are made. Because of the effect on the hepatic control system, you may have some severe difficulties with your general functioning if you have liver failure. Our present emphasis is on controlling the liver’s adverse effects, particularly the damage to hepatic tissues caused by conventional medications. We also went through individual signs and symptoms of liver disease, such as lipid catabolism, concurrent viral hepatitis, retained cell water, catabolism, and fibrosis and inflammation, all over the liver, in the liver, and excess, as well as inflammation and liver sickness, in particular. Different plant extracts (such as flavonoids, tannins, and vitamins) that have hepatoprotective properties, as well as the components that contribute to them, are discussed in this review article

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Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Cited by 11 publications

References 96 publications

Phytochemistry and pharmacological activity of the genus artemisia

Phytochemistry and pharmacological activity of the genus artemisia

Five traditional Nigerian Polyherbal remedies protect against high fructose fed, Streptozotocin-induced type 2 diabetes in male Wistar rats

Hepatoprotective Potentials of Some Emerging Indian Medicinal Plants

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