Hepatoprotective Effects of the Leaves of Agauria salicifolia against Acetaminophen-Induced Liver Injury in Mice

Tsague, Mathias Kenfack; Bomgning, Lionel C. K.; Fofié, Christian Kuete; Nguelefack‐Mbuyo, Elvine Pami; Fotio, Agathe Lambou; Nguelefack, Télesphore Benoît

doi:10.4236/jbm.2020.86007

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…The mitochondrial damage by the reactive metabolite of paracetamol is responsible for insufficient energy production with subsequent failure of the sodium pump and hydropic degeneration of the cell. These results are consistent with those observed [30,31]. Acute cell swelling can result in necrosis or can be reversible.…”

Section: Discussionsupporting

confidence: 93%

Liver protection from acetaminophen hepatotoxicity using copper(I)-nicotinic acid complex

2021

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The present study was performed to investigate the hepatotoxicity of acetaminophen and the possible hepatoprotective effect of copper(I)-nicotinate in rats through biochemical light and electron microscopy studies. Two groups of rats (39 in total) were used: group I (15 rats) received acetaminophen by intraperitoneal injection in a dose of 1000 mg/kg. While group II (15 rats) received an oral dose of 800 μg/kg copper(I)-nicotinate dissolved in 0.5 mL of saline three times through 24 h and 1 h after the last dose, and 9 rats were kept as control. Blood and tissue samples for biochemical, light, and electron microscop y were collected after 4, 12, and 24 h. Biochemical results showed a significant elevation in ALT, AST, and nitric oxide levels in rats who received acetaminophen only. In contrast, the corresponding levels of treated rats with the copper complex showed a less significant elevation in ALT, AST, and nitric oxide. Light microscopic examination of liver tissue taken from intoxicated animals showed congestion of the vasculature with hydropic and fatty degeneration. Centrilobular necrosis of the hepatocytes with glycogen depletion was observed in the centrilobular areas. Ultrastructural examination showed fatty degeneration, mitochondrial swelling, severe irregular dilatation of RER and SER, loss of glycogen granules, and pyknosis of the nuclei. Examination of livers of animals that received copper complex before intoxication revealed only cup-shaped mitochondria, a mild degree of fatty degeneration, and glycogen depletion with no evidence of necrosis. This work provides evidence for the antioxidant properties of the copper(I)-nicotinate complex and illustrates the pathological changes induced by acetaminophen in liver tissue.

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Section: Discussionsupporting

confidence: 93%

Liver protection from acetaminophen hepatotoxicity using copper(I)-nicotinic acid complex

2021

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“…The difference in hepatitis B prevalence rates in these different regions of the DRC can likely be attributed to the exposure to different risk factors according to population type, and probably arises from the absence of a viral hepatitis control and prevention program, as well as the fact that hepatitis B vaccination is limited to infants only. This variation in prevalence is also found in sub-Saharan Africa, where the rate of HBV infection, which is often very high, also varies with the country, the studied populations, and the used techniques [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. For example, the overall prevalence of 42.3% for anti-HBc antibody with 15.5% for HBsAg in students with high sexual activity in Bangui [23].…”

Section: Previous Studies On Hbv Infection Have Focused On Blood Dono...mentioning

confidence: 84%

High prevalence of hepatitis B and HIV among women survivors of sexual violence in South Kivu province, eastern Democratic Republic of Congo

Bisimwa,

Masemo,

Byabene

et al. 2023

Preprint

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Introduction: Limited data are available on the prevalence rates of hepatitis B and acquired immunodeficiency syndrome (AIDS) among women survivors of sexual violence (WSSV) in South Kivu province, in the eastern part of the Democratic Republic of Congo (DRC), where armed conflicts persist. Here, we aimed to assess the prevalence of these two diseases in this vulnerable local population. Methods: A total of 1002 WSSV, aged from 18 to 70 years old were enrolled from May 2018 to May 2020 at three one-stop centers, set up at the Panzi, Mulamba and Bulenga hospitals. Blood samples were collected and tested for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) antigens and antibodies using enzyme-linked immunoassay (ELISA) methods. Viral load quantification for HBV and HIV were performed using the GeneXpert. Results: For HBV, overall prevalence was 8.9% (95% CI [7.2–10.8%]), 32.1% [29.3–35.0%], and 14.5% [12.3–16.8%] for HBsAg, anti-HBc and anti-HBs antibodies, respectively. Among the 89 HBsAg-positive patients, 17 (19.1%) were HBeAg-positive. The mean age was 40.57±14.99 years in the HBsAg-positive group (p=0.025). Risk factors for HBV infection were age (≥35 years) (AOR=1.83 [1.02-3.32]; p=0.041), having no schooling (AOR=4.14 [1.35-12.62]; p=0.012) or only primary school-level (AOR=4.88 [1.61-14.75]; p=0.005), and multiple aggressors (AOR=1.76 [1.09-2.84], p=0.019). The prevalence of HIV was 4.3% [3.1–5.7%]. HIV/HBV co-infection occurred only in 5 individuals (0.5%). The HBV viral load was detectable (>2,000 copies/mL) in 61.8% of HBsAg-positive subjects and 64.8% HIV-positive subjects had a high viral load (>1,000 copies/mL). Conclusion: This study revealed a high prevalence of HBV and HIV infections among WSSV in South Kivu. These results highlight the urgent need for systematic screening of HBV and HIV by integrating fourth-generation ELISA tests in HIV and HBV control programs

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“…Several metabolic disorders are associated with significant hepatotoxicity and can even lead to death. Major risk factors pertinent to cirrhosis, steatohepatitis, hepatitis, and hepatotoxicity include xenobiotics, diabetes, obesity, pollutants, free radicals, food additives, and alcohol [ 3 , 4 ]. Liver diseases remain one of the most severe health problems, and their management is still a challenge to current medical care.…”

Section: Introductionmentioning

confidence: 99%

Development of a Hepatoprotective Herbal Drug from Turnera diffusa

Delgado-Montemayor

Cordero-Pérez

Torres-González

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The incidence of liver diseases, such as nonalcoholic fatty liver disease and drug-induced liver injury, continues to rise and is one of the leading causes of acute hepatitis. Current trends suggest that these types of conditions will increase in the coming years. There are few drugs available for the prevention or treatment of hepatic diseases, and there is a growing need for the development of safe hepatoprotective agents. The medicinal plant, Turnera diffusa, has many ethnopharmacological uses, one of which is the production of a flavonoid named hepatodamianol, which is the principal component responsible for this plant’s hepatoprotective properties. In the present study, we describe the development and standardization of an active extract obtained from T. diffusa. We conducted nuclear magnetic resonance spectroscopy to identify hepatodamianol unambiguously in each sample. Using this extract, hepatoprotection could be demonstrated in vivo for the first time. The hepatoprotective effect did not display a significant difference in vivo when compared with silymarin used as a positive control at the same doses. Implementation of quality criteria used for standardization, such as flavonoid and hepatodamianol content, hepatoprotective activity, and absence of residual solvents, will allow future preclinical trials with this herbal drug.

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Hepatoprotective Effects of the Leaves of Agauria salicifolia against Acetaminophen-Induced Liver Injury in Mice

Cited by 4 publications

References 21 publications

Liver protection from acetaminophen hepatotoxicity using copper(I)-nicotinic acid complex

Liver protection from acetaminophen hepatotoxicity using copper(I)-nicotinic acid complex

High prevalence of hepatitis B and HIV among women survivors of sexual violence in South Kivu province, eastern Democratic Republic of Congo

Development of a Hepatoprotective Herbal Drug from Turnera diffusa

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