Abstract:The present study was performed to investigate the hepatotoxicity of acetaminophen and the possible hepatoprotective effect of copper(I)-nicotinate in rats through biochemical light and electron microscopy studies. Two groups of rats (39 in total) were used: group I (15 rats) received acetaminophen by intraperitoneal injection in a dose of 1000 mg/kg. While group II (15 rats) received an oral dose of 800 μg/kg copper(I)-nicotinate dissolved in 0.5 mL of saline three times through 24 h and 1 h after the last do… Show more
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