Hepatoprotective Effects of the Honey of Apis cerana Fabricius on Bromobenzene‐Induced Liver Damage in Mice

Abstract

Apis cerana honey (honey of Apis cerana Fabricius), widely distributed in the mountain areas of East Asia, has not been studied fully. The hepatoprotective activity of A. cerana honey was evaluated against bromobenzene-induced liver damage in mice. In high dose, A. cerana honey can significantly alleviate liver injury, as is indicated by the depressed levels of serum alanine aminotransferase (ALT) (59.13%) and aspartate aminotransferase (AST) (79.71%), the inhibited malondialdehyde (MDA) content (63.30%), the elevated activities of superoxide dismutase (SOD) (73.12%) and glutathione-Px (57.24%), and the decreased expression of Transforming growth factor β1 (51.83%) induced by bromobenzene (P < 0.05). The quantitative analysis of twelve major constituents (1 to 12) of A. cerana honey was executed by high performance liquid chromatography-diode array detector. The results indicate that treatment with A. cerana honey can prevent bromobenzene-induced hepatic damage in mice. Polyphenols might be the bioactive substances attributed to its antioxidant properties and intervention of oxidative stress.

Therapeutic Implication of Honey against Chronic Carbon Tetrachloride-Induced Liver Injury via Enhancing Antioxidant Potential and Maintenance of Liver Tissue Architecture

“…In this regard, previous findings reported that apes cerana honey significantly improves the liver injury, as described by the decreased level of serum ALT, AST and inhibited malondialdehyde (MDA) content 11 .…”

“…Pretreatment with honey and silymarin before the administration of APAP significantly reduced the oxidative stress 15 . Another study demonstrated that A. cerana honey promoted SOD and glutathione peroxidase (GSH-Px) activities significantly 11 .…”

Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice

“…Bromobenzene (BB) is a general industrial reagent that is usually used as a raw material for the synthesis of pharmaceuticals, dyes, and pesticides. 1,2) BB is an organic pollutant that damages the natural environment and poses a serious threat to human health. One study state that BB induces severe hepatotoxicity and mild renal toxicity in mice.…”

Mitochondrial DNA based molecular phylogeny of Indian honeybee, Apis cerana F. in Bangladesh

“…A. cerana is highly resistant to diseases and also coevolved with the mite Varroa jacobsoni [8] and as a result, it grooms more carefully than A. mellifera, and it might be able to find dispel the bee mites from their colonies [9] . A. cerana nectar is predominant to other nectar since of its long nectar cycle and an assortment of nectar sources [10] . From the perspective of Bangladeshi beekeepers, A. cerana can itself be more successful.…”