Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

Baradaran, Atefeh; Samadi, F.; Ramezanpour, S. Sanaz; Yousefdoust, S.

doi:10.1016/j.toxrep.2019.07.011

Cited by 47 publications

(35 citation statements)

References 49 publications

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“…Plant-derived phenolic compounds have demonstrated the importance of their role in cancer prevention and treatment, which occurs mainly due to their ability to control the levels of ROS, induce differentiation and apoptosis, block signaling pathways, and suppress cell proliferation and angiogenesis [33,34]. As a consequence, phenolic compounds inhibit the initiation and progression of various cancer cells [35,36]. In this study, we have presented the first investigation of the phenolic profile of the aqueous ethanolic extract of the aerial parts of C. ignea .…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

et al. 2019

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“…Its supplementation attenuated the hepatocyte functional and histopathological alterations in acetaminophen-induced normotensive and hypertensive rats [ 13 ]. Also, Baradaran et al [ 10 ] stated that silymarin has a potential to alleviate CCl 4 -induced hepatotoxicity by up-regulating CAT, GPx, and Mn-SOD hepatic genes in CCl 4 -challenged birds.…”

Section: Introductionmentioning

confidence: 99%

Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino male rats

Rabey

Rezk²,

Sakran

et al. 2021

BMC Complement Med Ther

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Background During the last few decades, patients worldwide have been interested in using alternative medicine in treating diseases to avoid the increased side effects of chemical medications. Green coffee is unroasted coffee seeds that have higher amounts of chlorogenic acid compared to roasted coffee. Green coffee was successfully used to protect against obesity, Alzheimer disease, high blood pressure and bacterial infection. Methods This study aimed to investigate the probable protective activity of the green coffee methanolic extract, silymarin and their combination on CCl4-induced liver toxicity in male rats. Thirty Sprague – Dawley male albino rats were divided into 5 groups; control negative (G1) just got the vehicle (olive oil) and the other four groups received CCl4 dissolved in olive oil through an intraperitoneal injection and were divided into untreated control positive group (G2), the third group (G3) was treated with green coffee methanolic extract, the fourth group (G4) was treated with silymarin, and the fifth group (G5) was treated with a combination of green coffee methanolic extract and silymarin. Results In the positive control group treated with CCl4 (G2), the CCl4-induced toxicity increased lipid peroxidation, IL-6, kidney function parameters, liver function enzymes, total cholesterol, triglycerides and low-density lipoproteins, and decreased irisin, antioxidants, CYP450 and high-density lipoprotein levels. Hepatic tissues were also injured. However, treating the injured rats in G3, G4 and G5 significantly improved the altered parameters and hepatic tissues. Conclusions Green coffee methanolic extract, silymarin, and their combination succeeded in protecting the male rats against CCl4 hepatotoxicity due to their antioxidant activity. Effect of green coffee methanolic extract mixed with silymarin in G5 was more efficient than that of green coffee methanolic extract in G3 or silymarin in G4.

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“…In the broiler chicken industry, it is indispensable to monitor and manage of the oxidative stress because this event can directly affect the rate of production and increase the mortality rate of chicks [15]. Several investigations announced the administration of natural medicinal plants to control and decrease the adverse effects of oxidative stress on hepatic functions [16,17].…”

Section: Discussionmentioning

confidence: 99%

Study The protective Effects of Cichorium intybus L. Root Extract Against Carbon Tetrachloride-Induced Hepatotoxicity in Broiler Chickens

et al. 2021

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Medicinal plants have adequate potential to act as complete antioxidant agents. Antioxidants of these natural sources have no adverse carcinogenic, mutagenic and teratogenic effects of synthetic antioxidants and are readily available at low cost [4]. In recent years, there has been a great expansion in the application of these natural products as an antioxidants in the broiler industry [5]. Cichorium intybus L. (C. intybus), also recognized as chicory, has been employed in Iranian A N existing survey was performed to assess the hepatoprotective effects of C. intybus root extract on carbon tetrachloride-induced hepatotoxicity in broiler chickens. A total of 240 one-day-old broiler chickens were divided into diverse groups of control, carbon tetrachloride (1 mL/kg body weight IM injection), C. intybus root extract (500 mg/kg body weight/daily orally) and finally both C. intybus root extract and carbon tetrachloride. Liver samples were dissected and examined histopathologically at the day 31 of maintenance. Numerical grading of histopathological findings was performed according to the types of lesions at different criteria. Liver samples of carbon tetrachloride-treated group harbored moderate fatty degeneration and necrosis. Those treated with C. intybus extract showed normal cellular and tissue structure. Chicks faced with carbon tetrachloride and treated with C. intybus extract exhibited mild fatty degeneration and normal tissue structure. Chicks treated with C. intybus extract displayed the lowermost scores of necrosis (1.08±0.28), degeneration (1.33±0.49), inflammation (1.16±0.38) and total pathologic indexes (3.58±0.79). Broilers faced with carbon tetrachloride displayed the uppermost scores of necrosis (2.83±0.57), degeneration (3.66±0.49), inflammation (2.16±0.38) and total pathologic indexes (8.66±0.98). C. intybus extract application to broilers faced with carbon tetrachloride caused statistically significant decrease in the scores give to necrosis, degeneration, inflammation and total pathologic indexes (P <0.05). Findings suggested that 10 days administration of C. intybus extract caused significant decrease in the formation of centrilobular hepatic necrosis, fatty changes, inflammation and degeneration of the hepatic cells of broilers faced with CCl4-induced hepatotoxicity.

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Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

Abstract: Highlights The hepatoprotective activity of silymarin against CCl 4 -induced liver injury was achieved. Silymarin has potential to alleviate the side effects of CCl 4- induced oxidative stress. Silymarin enhanced oxidative stability by modulation antioxidant related genes.

Cited by 47 publications

References 49 publications

Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino male rats

Study The protective Effects of Cichorium intybus L. Root Extract Against Carbon Tetrachloride-Induced Hepatotoxicity in Broiler Chickens

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