Hepatoprotective effects of pecan nut shells on ethanol-induced liver damage

Müller, Liz Girardi; Pase, Camila Simonetti; Reckziegel, Patrícia; Barcelos, Raquel Cristine Silva; Boufleur, Nardeli; Prado, Ana Cristina Pinheiro do; Fett, Roseane; Block, Jane Mara; Pavanato, María A.; Bauermann, Liliane F.; Rocha, João Batista Teixeira da; Burger, Marilise Escobar

doi:10.1016/j.etp.2011.08.002

Cited by 49 publications

(29 citation statements)

References 33 publications

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“…The AE of the shells was freshly prepared by infusion (1:40 w/v, 90°C), filtered using filter paper, and cooled to room temperature. During this procedure, the extract was protected from light [11]. The criteria for the selection of the dose of pecan shells AE were based on previous studies conducted in our laboratory, and the initial range of dose was based on previous studies [11,12].…”

Section: Plant Materials and Preparation Of Ae Of C Illinoensis Shellsmentioning

confidence: 99%

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Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Trevisan

Rossato

Hoffmeister

et al. 2014

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Interest in pecan (Carya illinoensis) nut shells, a by-product of the nut industry, has increased due to its anti-inflammatory and antioxidant activities. The goal of this study was to evaluate the antinociceptive and antiedematogenic activity and the mechanisms of the pecan shell aqueous extract (AE). Methods: First, we performed fingerprinting of C. illinoensis AE. The antinociceptive and antiedematogenic effects of AE intragastric (i.g.) administration in mice (male Swiss mice 20-30 g) were evaluated using the acetic acid test or after subcutaneous (s.c.) paw injection of diverse transient receptor potential ankyrin 1 (TRPA1) agonists, including hydrogen peroxide (H2O2), allyl isothiocyanate, or cinnamaldehyde. We also observed AE antinociceptive and antiedematogenic effects after carrageenan s.c. paw injection and measured H2O2 production. Moreover, we observed the development of adverse effects after AE i.g. treatment. Results: The high-performance liquid chromatography fingerprinting of AE showed the presence of rutin. AE or rutin i.g. treatment produced antinociception in the acetic acid test and reduced the nociception and edema mediated by H2O2 s.c. hind paw injection or nociception induced by other TRPA1 agonists. Moreover, AE or rutin reduced the hyperalgesia, edema, and H2O2 production induced by carrageenan s.c. paw injection. No motor, gastric, or toxicological alterations were observed after AE administration. Conclusions: Collectively, the present results show that AE and its constituent rutin produced antinociceptive and antiedematogenic action in models of acute and persistent inflammatory nociception and it seems to be related to the inhibition of TRPA1 receptor activation.

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Section: Plant Materials and Preparation Of Ae Of C Illinoensis Shellsmentioning

confidence: 99%

“…Pecan shells have been pointed as a good source of antioxidant compounds [6,9]. In fact, the antioxidant activity of pecan shells was related with a wide range of pharmacological properties [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Trevisan

Rossato

Hoffmeister

et al. 2014

Journal of Basic and Clinical Physiology and Pharmacology

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“…Pecan nutshell is a phenolic rich agro-industrial byproduct, which polyphenolic profile includes high concentration of gallic acid, chlorogenic acid, p-hydroxybenzoic acid, epigallocatechin and epicatechin gallate (Prado et al, 2014). Due to the elevated concentration of polyphenols, the consumption of its infusion is associated with antioxidant activity, decreasing liver damage, reduction of total cholesterol and action as natural anxiolytic (Malik et al, 2009;Prado et al, 2014;Reckziegel et al, 2011, Müller et al, 2013. Additionally to the benefits to human health, Prado et al (2014) found that pecan nutshell infusion presents antibacterial activity against Gram-positive bacteria such as Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus, Vibrio parahaemolyticus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antimicrobial activity of pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell aqueous extract on minimally processed lettuce leaves

et al. 2016

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Pecan nutshell is a residue from food industry that has potential to be used as biopreservative in foods. The objective of this study was to evaluate the antimicrobial activity of pecan nutshell aqueous extract in vitro and its effectiveness to inhibit spoilage microorganisms on lettuce leaves. The results indicate that the aqueous extract presents inhibitory activity against important foodborne pathogenic bacteria such as Listeria monocytogenes, Salmonella Enteritidis, Staphylococcus aureus, Bacillus cereus, Aeromonas hydrophila and Pseudomonas aeruginosa. Antimicrobial activity was not observed against Corynebacterium fimi, Clostridium perfringens, Escherichia coli, and the phytopathogenic fungi tested. When applied onto lettuce leaves, pecan nutshell extract reduced the counts of mesophilic and psychrotrophic bacteria in 2 and 4 log CFU/g, respectively, during storage of leafy for 5 days at refrigeration temperature (5 °C). The extract was not effective to inhibit yeast on lettuce leaves. Thus, the aqueous extract of pecan shell showed great potential to be used as a natural preservative in foods, acting mainly in the inhibition of spoilage and pathogenic bacteria.

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“…The importance of g-GT is being a marker enzyme for hepatic injury which is induced by drugs and this enzyme carries weight with in clinical practice. Some reporters have reported elevated g-GT activity levels in various either human hepatocyte culture studies induced by amiodarone or chemical-induced hepatotoxicity cases (37)(38)(39). Increased activity of this enzyme shows impairment for membrane integrity.…”

Section: Resultsmentioning

confidence: 99%

Vitamin U ameliorates glycoprotein components, enzyme and tissue factor activities of amiodarone toxicity in liver

Türkyılmaz

Yanardağ

2016

Marmara Pharm J

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In this study, we aimed to investigate the protective effect of Vitamin U (Vit U) on amiodarone (AMD)-induced hepatotoxicity. Male Sprague-Dawley rats were randomly divided into four groups. Group I was control animals receiving corn oil for 7 days, Group II consisted of animals receiving Vit U (50 mg/kg) for 7 days, Group III consisted of animals receiving AMD (100 mg/kg) for 7 days and Group IV consisted of animals given AMD and Vit U (in same dose and time). AMD and Vit U were administered to rats by gavage. On the 8th day, all the animals fasted overnight were sacrificed. Blood and liver tissue samples were taken from animals. Serum total cholesterol levels and liver gamma glutamyl transferase (transpeptidase) adenosine deaminase and tissue factor activities, liver glycoprotein component level such as fucose, hexose and hexosamine were determined. All the parameters were found to be increased in AMD group as compared to control group. Administration of Vit U reversed these effects in AMD group. According to these results, we can conclude that Vit U can prevent AMD-induced liver injury.

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Hepatoprotective effects of pecan nut shells on ethanol-induced liver damage

Cited by 49 publications

References 33 publications

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

Evaluation of the antimicrobial activity of pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell aqueous extract on minimally processed lettuce leaves

Vitamin U ameliorates glycoprotein components, enzyme and tissue factor activities of amiodarone toxicity in liver

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