Hepatoprotective effects of Panax notoginseng: Ginsenosides -Re and —Rg1 as its active constituents in D-galactosamine/lipopolysaccharide-induced liver injury

Prasain, Jeevan K.; Kadota, Shigetoshi; Basnet, Purusotam; Hase, Koji; Namba, Tsuneo

doi:10.1016/s0944-7113(96)80072-9

Cited by 15 publications

(9 citation statements)

References 12 publications

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“…From the results obtained in this study, we concluded that hepatoprotective activity of MR2 should be exerted both through an inhibition of TNF-a production by activated macrophages and through a direct inhibition of apoptosis induced by TNF-a. Pre- viously, on evaluation of the hepatoprotective effect of P. notoginseng on D-GalN/LPS-induced liver injury in mice, ginsenoside Rg 1 was identified as one of its active constituents [4] and was found in Vietnamese ginseng also with rather high content [1]. Thus, the hepatoprotective effect of Vietnamese ginseng could be concluded to be due to its saponin constituents, which may be useful in treatment of liver diseases in human beings.…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis)

et al. 2002

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The hepatoprotective effect of majonoside R 2 (MR2), the major saponin constituent from Vietnamese ginseng ( Panax vietnamensis, Araliaceae), was evaluated in vivo on D-galactosamine ( D-GalN)/lipopolysaccharide (LPS)-induced hepatic apoptosis and subsequent liver failure in mice. Pretreatment of mice with MR2 (50 or 10 mg/kg, intraperitoneal) at 12 and 1 h before D-GalN/LPS injection significantly inhibited apoptosis and suppressed following hepatic necrosis. Importantly, the elevation of serum tumor necrosis factor-alpha (TNF-alpha) level, an important mediator for apoptosis in this model, was significantly inhibited by MR2 at a dose of 50 mg/kg. On the other hand, MR2 was found to protect primary cultured mouse hepatocytes from cell death by inhibiting apoptosis induced by D-GalN/TNF-alpha in vitro, as evidenced by DNA fragmentation analysis. These findings suggested that MR2 may have protected the hepatocytes from apoptosis via an inhibition of TNF-alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF-alpha.

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Section: Discussionmentioning

confidence: 99%

“…Several papers have been published on the hepatoprotective effects of P. ginseng, P. notoginseng and P. japonicus [2], [3], [4]. Recently, Nguyen et al reported that total saponins of Vietnamese ginseng partly prevented CCl 4 -induced hepatotoxicity in mice [5].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis)

et al. 2002

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“…Ginsenoside Rd inhibits iNOS and cyclooxygenase (COX)-2 expression and NF-κB activation in the liver of rats treated with LPS [35]. In addition to ginsenosides Rc and Rd, ginsenosides Re and Rg1 were found to reduce blood ALT in mice with LPS/D-galactosamine-induced liver injury [36]. Ginsenoside Rg3 has also been reported to significantly decrease LPS-induced blood AST and ALT levels and liver HO-1 expression in rats [37].…”

Section: Multiple Efficacies For Hepatic Injuriesmentioning

confidence: 99%

Ginseng for Liver Injury: Friend or Foe?

Kim

2016

Medicines

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Panax sp., including Panax ginseng Meyer, Panax quiquifolius L., or Panax notoginseng (Burk.) FH Chen, have been used as functional foods or for traditional Chinese medicine for diabetes, inflammation, stress, aging, hepatic injury, and cancer. In recent decades, a number of both in vitro and in vivo experiments as well as human studies have been conducted to investigate the efficacy and safety of various types of ginseng samples and their components. Of these, the hepatoprotective and hepatotoxic effects of ginseng and their ginsenosides and polysaccharides are reviewed and summarized.

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“…"Pian Zi Huang", a famous Chinese traditional formula consisting of P. notoginseng, has been used for the treatment of viral hepatitis. An increasing number of animal studies have demonstrated that P. notoginseng and its saponins exerted protective effects against hepatic ischemia/reperfusion (Zhang et al, 2005), D-galactosamine/lipopolysaccharide-induced liver injury (Prasain et al, 1996), liver fibrosis and hepatic microvascular dysfunction (Park et al, 2005). However, the possible effect of P. notoginseng saponins (PNS) on chronic alcoholinduced liver injury has not been fully understood yet.…”

Section: Introductionmentioning

confidence: 99%

UPLC/Q-TOFMS-Based Metabolomics Studies on the Protective Effect of Panax notoginseng Saponins on Alcoholic Liver Injury

Liu

Ding

et al. 2015

Am. J. Chin. Med.

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Consistent, excessive alcohol consumption leads to liver injury. The aim of the present study is to evaluate the possible efficacy of Panax notoginseng saponins (PNS) against chronic alcohol-induced liver injury using LC-MS-based urinary metabolomics. Mice were fed a Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin as a control diet with or without PNS (200 mg/kg/BW) for 4 weeks. Treatment with PNS significantly reduced the increases in plasma ALT and AST levels, hepatic levels of reactive oxygen species (ROS) and malondialdehyde (MDA), which induced by chronic alcohol exposure. Conversely, PNS was also found to restore the glutathione (GSH) depletion and increase the superoxide dismutase (SOD) activities. The end-point urine sample of each mouse was collected overnight (24 h) in metabolic cages and their metabolic profiling changes were analyzed using UPLC/Q-TOFMS followed by multivariate statistical analysis. After 4 week of Lieber-DeCarli alcohol diet feeding, the metabolic profile experienced great perturbation in PCA score plot, and the treatment of PNS could assist to regulate the disturbed metabolic profile induced by alcohol exposure. Additionally, sixteen potential biomarkers responsible for derivations of the metabolic profile induced by alcohol exposure were identified, and the alcohol-induced changes in these biomarkers, except hexanoylglycine, could be partially or nearly reversed by PNS treatment. Taken together, PNS protects against chronic alcohol-induced liver injury. Our findings demonstrated that the LC-MS-based metabolomics approach is a useful tool to investigate the efficacy of Chinese medicines.

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Hepatoprotective effects of Panax notoginseng: Ginsenosides -Re and —Rg1 as its active constituents in D-galactosamine/lipopolysaccharide-induced liver injury

Cited by 15 publications

References 12 publications

Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis)

Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vietnamese Ginseng (Panax vietnamensis)

Ginseng for Liver Injury: Friend or Foe?

UPLC/Q-TOFMS-Based Metabolomics Studies on the Protective Effect of Panax notoginseng Saponins on Alcoholic Liver Injury

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