Ginseng for Liver Injury: Friend or Foe?

Kim, Tae Woo

doi:10.3390/medicines3040033

Cited by 10 publications

(6 citation statements)

References 122 publications

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“…It was evident that, while high‐fat diet induced the increases in marker enzymes for liver function (ALT and AST), nutritional interventions (HFD+BGE and HFD+AGE) led to marked decreases in these liver enzymes, thereby ameliorating the damaging effects of NAFLD. It is likely that the improvement of liver function could be due to the hepatoprotective effects of Rb1 and CK ginsenosides along with Rg3 and Rh2, which act against liver injuries caused by tert‐Butyl hydroperoxide (Kim, 2016).…”

Section: Resultsmentioning

confidence: 99%

Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice

Jiang

Ramachandraiah

Murtaza

et al. 2021

Food Science & Nutrition

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Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that can lead to carcinoma, cirrhosis, and death. Since no approved medications are available, dietary interventions that include bioactive compounds have been recommended. This study investigated the effects of black ginseng extracts (BGE) and aged black garlic extracts (AGE) on high‐fat diet (HFD)‐induced obese mice. Micrograph of liver tissues of mice fed with BGE and AGE showed less lipid droplets. The BGE and AGE supplements individually and in combination lowered the marker enzymes, aminotransferase (AST), and alanine aminotransferase (ALT) levels indicating their hepatoprotective effects. Compared to the plants extracts alone, the combination of the extracts resulted in lower total cholesterol (TC) and low‐density lipoproteins cholesterol (LDL‐C), which are risk markers for cardiovascular morbidity and mortality. Diets with the combination of BGE and AGE supplements had higher superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px) activities, and lower malondialdehyde indicating the synergistic effects of the extracts. Irrespective of the diet type, all treated groups showed lower tumor necrosis factor (TNF‐α) values as compared to HFD, which indicated overall immunomodulatory effect of both extracts. Therefore, the innovative formulation formed by the combination of BGE and AGE can provide hepatoprotective effects via modulating glycometabolism, lipometabolism, oxidative stress, and inflammation in mice.

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Section: Resultsmentioning

confidence: 99%

Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice

Jiang

Ramachandraiah

Murtaza

et al. 2021

Food Science & Nutrition

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“…Furthermore, physiological changes in the liver are commonly caused by the use of exogenous compounds such as drugs, herbs, and alcohol 11 . These liver toxicities are well screened clinically with indicators such as aspartate transaminase (AST) and alanine aminotransferase (ALT) 12 , and the two indicators are used to directly judge the effect of ginseng on liver function 13 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

Kwon

et al. 2021

Sci Rep

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Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (H2S) synthesis in the liver. This investigation provides novel evidence that sub-chronic administration of KRG can elevate H2S production by increasing protein expression of CBS and CSE in the liver.

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“…has been reported to potential bring about side effect on lipid profi le [12]. This would be a paradoxical even considering that the most common liver disease is fatty liver which may have a progressive nature [13] and associated to other metabolic syndrome dysfuntions [14][15][16][17]. Also Gamboge has blurred its popularity after serious concerns were raised for its potential damage on the redox and infl ammatory citokines balance.…”

mentioning

confidence: 99%

Do we really need nutraceutical liver support? Experimental effectiveness, risks and proven clinical benefits

Marotta¹,

Lorenzetti²,

Rasulova³

et al. 2021

Open J Hepatol

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Ginseng for Liver Injury: Friend or Foe?

Cited by 10 publications

References 122 publications

Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice

Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice

Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

Do we really need nutraceutical liver support? Experimental effectiveness, risks and proven clinical benefits

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