Hepatoprotective effects of Nigella sativa and bees' honey on hepatotoxicity induced by administration of sodium nitrite and sunset yellow

Abstract

BackgroundThe study was conducted to shed the light on adverse effects of food additive such as sodium nitrite (NaNO2; as preservative) and sunset yellow (as color) on the rat liver. Furthermore, the study was extended to show the protective role of Nigella sativa (black seed) and bees' honey in modulating the toxic effects induced by these additives.Methods‐resultsData show that the administration of NaNO2 and sunset yellow caused significant increase in serum and liver total lipids, total cholesterol, riglycerides and phospholipids levels. Also, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities were increased in serum and liver of rats. Oxidative stress markers; lipid peroxidation product and protein carbonyl group were increased in the liver. However, the antioxidants glutathione content, glutathione‐S‐transferase and catalase activities were decreased significantly in the liver tissue. Interestingly, a complete recovery of most of biochemical abnormalities was observed when black seed and bees' honey were administered, in combination, to rats intoxicated with NaNO2 and Sunset yellow.ConclusionWe conclude that bees' honey is more hepatoprotective than black seed but the administration of both agents together has a better liver‐protection effect rather. Black seed and bees' honey should be used in Human food additives based on their protector effect

Protective Effect of Combination Black Seed Oil (Nigella sativa) and Honey on the Duodenum of Rats Exposed to Cisplatin

“…Our study revealed that the administration of the combination of BSO and honey in variety provides a better effect than a single treatment of BSO or honey. This result is in line with a study conducted by El-Kholy et al, a better protective effect on the liver was obtained after the combination of BSO and honey was given (20). This study was an experimental study, which was carried out by comparing histopathological preparations between the normal control group, negative control group, and the exposure group so that the types of damage that occurred could be compared.…”

دور مستخلصي حبة البركة و العرق سوس علي تكيسات المبايض في فئران التجارب

“…Moreover, it succeeded to induce an improvement in kidney function. Our results are in agreement with previous data reporting that N. sativa and licorice have a wide margin of safety (EL-Kholy et al, 2009, AL Ameen et al, 2011. Effect of Nigella stevia and Licorice extract on histological characteristics of Ovary in rats.. Light microscopic examination of ovarian sections of the control group stained with hematoxylin and eosin showed the normal histological structure of the ovary with normal cortical and medullary regions, including primary and secondary follicles (Fig.…”

Honey as a Functional Food; Its Culinary Status

“…In another study carried out over rats, it was found that stomach lesions of the subjects fed with daily honey diet (Zanini et al, 2014). In the use of bee honey with the seeds of black cumin (Nigella sativa L.), it was found that it has protective effects upon hepatoxicity, oxidative stress and carcinogenesis (El-Kholy et al, 2009). However, there could be some reactions varying from simple cough to anaphylaxis in allergic bodies with the consumption of uncontrollably produced honeys and it is necessary to warn in this sense (Martos et l., 2008).…”