Hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated rats

Lim, Hyun; Kim, Hack Seang; Choi, Hanlim; Oh, Seikwan; Choi, Jongwon

doi:10.1016/s0378-8741(00)00260-9

Cited by 99 publications

(36 citation statements)

References 19 publications

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“…Cleavage takes place after binding of CCl 4 to cytochrome p-450 apoprotein in the mixed function system located in the hepatocellular endoplasmic reticulum (19). CCl 4 cleaved into trichloromethyl radical (CCl 3 º), which further reacts with molecular oxygen to form trichlormethyl peroxy radicals (CCl 3 O 2 º) (20,21).…”

Section: Hypocholesterolemic and Hepatoprotective Effects Of Flaxseedmentioning

confidence: 99%

Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

Shakir

Madhusudhan

2007

Indian J Clin Biochem

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Section: Hypocholesterolemic and Hepatoprotective Effects Of Flaxseedmentioning

confidence: 99%

Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

Shakir

Madhusudhan

2007

Indian J Clin Biochem

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“…Previously bergenin had also been isolated from E. uchi fruits (Magalhães et al, 2007) and also many other species, including species of the family as Humiria balsamifera (Caldas et al, 2002) and Sacoglottis gabonensis (Ogan, 1971). Bergenin presents several biological activities such as anti-inflammatory (Swarnalakshmi et al, 1984;Nazir et al, 2007), antioxidant (Sumino et al, 2002), hepatoprotective (Lim et al, 2000), neuroprotective (Takahachi et al, 2003), and anti-HIV (Piacente, 1996). Bergenin also presents antifungal activity against some plant pathogenic fungi (Prithiviraj et al, 1997 …”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of bergenin from Endopleura uchi (Huber) Cuatrec

et al. 2009

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Endopleura uchi (Huber) Cuatrec. is an Amazon species traditionally used as treatment for inflammations and female disorders. Bergenin was isolated from ethyl acetate fraction of bark of E. uchi by using column chromatography over sephadex LH-20 and then silica gel 60 flash. Its structure was identified on the basis of its NMR spectra. The antimicrobial activity of bergenin and fractions of methanol extract of E. uchi were evaluated against ATCC microorganisms (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Candida albicans, C. guilliermondii, Aspergillus flavus, A. nidulans). Clinically isolated strains of all of these microorganisms, along with C. tropicalis, A. niger, Shigella sonnei, Serratia marcenses and Klebsiella pneumoniae were also evaluated. The growth inhibition caused by bergenin, extracts and fractions of E. uchi against ATCC microorganisms were similar to the inhibition to microorganisms clinically isolated. The ethyl acetate fraction and the isolate bergenin inhibit the growth of the yeasts C. albicans, C. tropicalis, and C. guilliermondii, but present lower activity against filamentous fungi Aspergillus flavus, A. nidulans, A. niger, and did not inhibit the Gram positive and Gram negative bacteria. The activity of the ethyl acetate fraction and bergenin are in agreement wit its high concentration found in bark extract of E. uchi. Moreover, the selective activity against three Candida species helps to understand its traditional use against infections that affect women.KEYWORDS: Antibacterial, Antifungal, Candida, Humiriaceae, Uxi-amarelo.Atividade antimicrobiana de bergenina isolada de Endopleura uchi (Huber) Cuatrec. RESUMOEndopleura uchi (Huber) Cuatrec. é uma espécie amazônica utilizada tradicionalmente para o tratamento de inflamações uterinas e outras afecções femininas. Das cascas de E. uchi foi isolada a substância bergenina, por meio de cromatografia em coluna usando como fases estacionárias sephadex LH-20 e posteriormente, sílica gel 60 flash. A identificação estrutural de bergenina foi realizada por meio de espectros de RMN. A avaliação da atividade antimicrobiana da bergenina, dos extratos e frações de E. uchi foi realizada contra microorganismos ATCC e clinicamente isolados (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Candida albicans, C. guilliermondii, Aspergillus flavus, A. nidulans). Além desses, foram testados os microorganismos isolados clinicamente (C. tropicalis, A. nidulans, A. niger, Shigella sonnei, Serratia marcenses, Klebsiella pneumoniae e Enterococcus faecalis).A inibição de crescimento dos microorganismos pela bergenina e extratos e frações de E. uchi contra os microorganismos ATCC foram similares à inibição obtida contra microorganimos isolados clinicamente. Os resultados revelaram a bergenina como um inibidor seletivo de Candida albicans, C. tropicalis e C. guilliermondii. Porém, a bergenina apresentou uma atividade inferior co...

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“…The results indicated that 500 mg kg −1 dose of FRSACE offers optimal hepatoprotection. The hepatoprotective effect of FRSACE could conclusively be attributed to the presence of bergenin; an isocoumarin, since it is reported to exhibit significant hepatoprotective activity against CCl 4 -induced hepatotoxicity in rats (Lim et al, 2000).…”

Section: Cardioprotective Effectmentioning

confidence: 90%

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

Ahmed

Urooj

2011

Pharmaceutical Biology

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Hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated rats

Cited by 99 publications

References 19 publications

Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies

Antimicrobial activity of bergenin from Endopleura uchi (Huber) Cuatrec

Cardioprotective activity of standardized extract ofFicus racemosastem bark against doxorubicin-induced toxicity

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