Hepatoprotective Effect of Probiotic <i>Lactobacillus rhamnosus</i> GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish

Bruch-Bertani, Juliana Paula; Cruz, Carolina Uribe; Pasqualotto, Amanda; Longo, Larisse; Ayres, Raquel; Beskow, Carolina Bortolin; Barth, Afonso Luís; Lima-Morales, Daiana de; Meurer, Fábio; Guerreiro, Gabriel Tayguara Silveira; Silveira, Themis Reverbel da; Álvares‐da‐Silva, Mário Reis; Dall’Alba, Valesca

doi:10.1080/07315724.2019.1627955

Cited by 15 publications

(5 citation statements)

References 30 publications

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“…A recent Brazilian study in zebrafish evaluated the effects of exposure to alcohol in the aquarium water, fed or not with probiotics. In the treated animals, there was a decrease in hepatic steatosis, a decrease in systemic inflammation assessed by the activation of inflammasomes, and an increase in cldn15a expression, suggesting a protective effect of the probiotic (100) .…”

Section: Decompensated Cirrhosismentioning

confidence: 90%

Gut Microbiota, Prebiotics, Probiotics, and Synbiotics in Gastrointestinal and Liver Diseases: Proceedings of a Joint Meeting of the Brazilian Society of Hepatology (Sbh), Brazilian Nucleus for the Study of Helicobacter Pylori and Microbiota (Nbehpm), and Brazilian Federation of Gastroenterology (Fbg)

Schiavon¹,

Oliveira

Álvares‐da‐Silva

et al. 2020

Arq. Gastroenterol.

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Over the last years, there is growing evidence that microorganisms are involved in the maintenance of our health and are related to various diseases, both intestinal and extraintestinal. Changes in the gut microbiota appears to be a key element in the pathogenesis of hepatic and gastrointestinal disorders, including non-alcoholic fatty liver disease, alcoholic liver disease, liver cirrhosis, inflammatory bowel disease, irritable bowel syndrome, and Clostridium difficile - associated diarrhea. In 2019, the Brazilian Society of Hepatology (SBH) in cooperation with the Brazilian Nucleus for the Study of Helicobacter Pylori and Microbiota (NBEHPM), and Brazilian Federation of Gastroenterology (FBG) sponsored a joint meeting on gut microbiota and the use of prebiotics, probiotics, and synbiotics in gastrointestinal and liver diseases. This paper summarizes the proceedings of the aforementioned meeting. It is intended to provide practical information about this topic, addressing the latest discoveries and indicating areas for future studies.

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Section: Decompensated Cirrhosismentioning

confidence: 90%

Gut Microbiota, Prebiotics, Probiotics, and Synbiotics in Gastrointestinal and Liver Diseases: Proceedings of a Joint Meeting of the Brazilian Society of Hepatology (Sbh), Brazilian Nucleus for the Study of Helicobacter Pylori and Microbiota (Nbehpm), and Brazilian Federation of Gastroenterology (Fbg)

Schiavon¹,

Oliveira

Álvares‐da‐Silva

et al. 2020

Arq. Gastroenterol.

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“…The increase in consumption of industrialized fructose may be related to the accelerated growth in the number of overweight and obese young people 28 and, consequently, with the increase in nonalcoholic liver disease in this group. 29,30 The zebrafish has been a very suitable model to study liver diseases caused by various etiological factors: alcohol, [31][32][33] hepatotoxic drugs, 34 obesity, 35,36 and also fructose. 37,38 The article by Sapp and colleagues was the first to report that acute exposure to fructose (4%) in zebrafish larvae, induced the development of liver steatosis and activation of inflammatory and lipogenic genes.…”

Section: Discussionmentioning

confidence: 99%

Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose

et al. 2021

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Melatonin is a hormone related to circadian rhythms and has potential clinical applications. Our objectives were to verify the effect of melatonin on the liver of zebrafish exposed to fructose and evaluate the expression of appetite-related genes (leptin, ghrelin, and melanocortin receptor 4 [MC4R]). Animals were divided into three groups: control (CG, n = 25), fructose (FG, n = 25), and fructose+melatonin (FMG, n = 25). The study was carried out in 8 weeks. FG and FMG were exposed to 2% fructose and FMG treated with 1 lM of melatonin. Histological liver studies and gene expression analyses of Leptin, Ghrelin, and MC4R (liver and intestines) were performed. FG developed hepatic steatosis, which did not occur with CG and FMG. Genetic expression of hepatic leptin and MC4R did not show significant difference among the groups. Animals exposed to fructose (FG) presented an increased expression of intestinal leptin compared to those administered with melatonin. Animals exposed to fructose gained weight and developed an important hepatic steatosis, but melatonin reduced significantly the hepatic damage. Intestinal leptin showed increased expression in the group exposed to fructose.

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“…[ 15 , 54 , 55 ]. Probiotics reduce oxidative stress, inflammation, and fibrosis, all of which play a role in the etiology of a variety of liver diseases [ 15 , 56 , 57 ]. Probiotics primarily work by altering the composition and activity of the normal gut flora.…”

Section: Hepatoprotective Mechanisms Of Probioticsmentioning

confidence: 99%

Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity

et al. 2022

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Acetaminophen (APAP) is the most common prescription medicine around the world for the treatment of pain and fever and is considered to be a safe drug at its therapeutic dose. However, a single overdose or frequent use of APAP can cause severe acute liver injury. APAP hepatotoxicity is a prevalent cause of acute liver disease around the world and the lack of suitable treatment makes it a serious problem. In recent years, there has been a surge in interest in using probiotics and probiotic-derived products, known as postbiotics, as health and disease negotiators. A growing body of evidence revealed that they can be equally effective against APAP hepatotoxicity. Different probiotic bacteria were found to be pre-clinically effective against APAP hepatotoxicity. Different postbiotics have also shown exciting results in preclinical models of APAP hepatotoxicity. This review summarized the protective roles and mechanisms of the different probiotic bacteria and postbiotics against APAP hepatotoxicity, with critical discussion. A brief discussion on potential novel probiotics and postbiotics for oxidative liver injury was also included. This review was written in an attempt to pique the interest of researchers in developing a safe therapeutic option against oxidative liver damage using probiotics and/or postbiotics as dietary supplements.

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Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish

Cited by 15 publications

References 30 publications

Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose

Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity

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