Hepatoprotective effect of olive oil and camel milk on acetaminophen-induced liver toxicity in mice

Ibrahim, Mahrous A.; Wani, Farooq Ahmed; Rahiman, Shaik

doi:10.5455/ijmsph.2017.07092016614

Cited by 19 publications

(20 citation statements)

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“…All these constituents are potent antioxidants can protect liver cells from injury (Barbagallo et al, 1999;Althnaian, 2012). In accordance with the results of the current study, Ibrahim et al (2017) showed that CM has hepatoprotective action against acetominophenon induced hepatotoxicity in mice, possibly in part through antioxidative effects. El Miniawy et al (2017) ascribed this positive effect of CM to the improvement observed in SOD activity and reduction of the lipid peroxidation.…”

Section: Discussionsupporting

confidence: 92%

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Zahran¹,

SA²,

El-Moneim³

et al. 2018

JEBAS

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Present study has been carried out evaluate prophylactic effect of Camel milk on physiological and biochemical changes in CCl4-intoxicated rats. A total of 36 male albino rats were randomly divided into 6 groups viz. control group (G1), silymarin (SM) group (G2), camel milk (CM) group (G3), CCl4-intoxicated group (G4), silymarin prophylactic group (G5) and camel milk prophylactic group (G6). Each group has six rats. After completion of the study (8 wks), blood samples were collected and hematological parameters, liver contents of glutathione (GSH), malondialdhyde (MDA) , superoxide dismutaseactivity (SOD), serum urea, uric acid, creatinine, testosterone, estradiol were measured. The results of this study revealed that CCl4 toxicity significantly reduced Hb level, RBCs count and PCV, whereas it significantly increased the WBCs count with respect to normal control. Intoxication of CCl4 in G4 rats led to microcytic hypochromic anaemia, increased erythrocyte fragility and, leukocytosis was accompanied neutrophils increases and a decrease in lymphocyte counts. Also, CCl4 produced significant increase in serum urea, uric acid, creatinine and estradiol level and decrease in circulating testosterone level compared with normal rats. Pre-treatment with CM and SM brought significant restoration in hematological, renal function parameters and sexual hormones disturbance. Moreover, lipid peroxidation and oxidative stress were obviously noted in CCl4 intoxicated (G4) organism where a

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Section: Discussionsupporting

confidence: 92%

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Zahran¹,

SA²,

El-Moneim³

et al. 2018

JEBAS

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“…Moreover, paracetamol administration elevated the lipid peroxidation as supported by the significant increase in liver MDA level which confirms the presence of hepatic damage as a result of promoted lipid peroxidation during the damage of tissue and the failure of antioxidant defense mechanism to inhibit the formation of free radicals. This matches with Hinson et al (2010) and Ibrahim et al (2017) who reported that lipid peroxidation has been produced due to liver damage by paracetamol administration.…”

Section: Discussionsupporting

confidence: 91%

“…Paracetamol is metabolized into sulfate and glucuronide. Liver is the main site of detoxification and is highly susceptible to these agents toxicity (Ibrahim et al, 2017). In therapeutic uses, the produced substances are conjugated with glutathione.…”

Section: Discussionmentioning

confidence: 99%

“…The liver metabolized paracetamol and gives highly reactive metabolites. When the production rate of these metabolites exceeds the detoxification rate by glutathione, it causes oxidation to the tissue macromolecules and induce lipid peroxidation, glutathione depletion and damage to hepatocytes (Ibrahim et al, 2017). These damaged hepatocytes activate the immune system resulting in the synthesis of proinflammatory cytokines (Abd El-Ghffar et al, 2017).…”

Section: Benha University Faculty Of Veterinary Medicinementioning

confidence: 99%

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Vitamin E is a potent regulator of inflammatory cytokines released during hepatic toxicity in rats

Shemy

Farid

2018

Benha Veterinary Medical Journal

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Paracetamol is a the most utilized analgesic and antipyretic drug, but it may induce hepatotoxicity at increased doses. So, we design this experiment to study the hepatotoxic effect of paracetamol and to detect the role of vitamin E in the alleviation of this toxic effect. Forty Wistar male rats were classified into 4 groups (10 rats per group); Control (distilled water), Vitamin E (100 mg/kg b. wt. orally for four weeks), Paracetamol (1000 mg/kg b. wt. orally for 3 consecutive days), Vitamin E plus Paracetamol (100 mg vitamin E/kg b. wt. orally for four weeks followed by a dose of paracetamol 1000 mg/kg b. wt. orally daily for 3 consecutive days). Blood and hepatic specimens were collected at the end of treatment. Erythrogram, leukogram, liver enzymes, MDA and expressions of IL-1β, IL4, MCP-1 and TGF mRNA were determined. Also, tissue sections from liver was examined histopathologically. Paracetamol caused damage of liver tissue indicated by significant increase in the serum ALT and AST activities with a significant decrease in the levels of serum total protein and albumin. Moreover, paracetamol produced a significant elevation in the level of liver malondialdehyde and significant upregulations in the pro-inflammatory biomarkers expression in the hepatic homogenate. The hepatic tissue revealed severe inflammation and hepatic damage. However, vitamin E alleviated the oxidative stress and the hepatotoxicity induced by paracetamol. Our experiment revealed that Paracetamol is a hepatotoxic drug in rats. Meanwhile, vitamin E reverses that harmful hepatotoxic effects produced by Paracetamol.

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“…Animals were given extra virgin olive oil orally at a daily dose of 2 mL/kg body weight for 28 days[33].…”

mentioning

confidence: 99%

Cytoprotectant and Anti-Oxidant Effects of Olive Oil on Cadmium Induced Nephrotoxicity in Mice

Wani¹,

Ibrahim²,

Moneim³

et al. 2018

OJPathology

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Background: Cadmium is a heavy metal having toxic effects on most organ systems of the body. Objectives: We aim to investigate the postulated protective properties of olive oil in Cadmium-induced renal toxicity in mice by utilizing standard biomarkers of renal toxicity, oxidative stress and histopathological characterization. Materials and Methods: Forty mice were randomly divided into four groups of 10 mice each. Group 1 served as control group, group 2 was given Extra-virgin olive oil orally, group 3 was given Cadmium chloride and group 4 was given Cadmium chloride with Extra-virgin olive oil. At the end of the experimental period, biochemical analysis histopathology of kidney was done. Results: The present study depicted that blood urea, serum creatinine and the antioxidant markers (Superoxide dismutase, Glutathione peroxidase and Catalase) levels were significantly increased in group 3 compared to group 1 and 2. After administration of Extra-virgin olive oil with Cadmium in group 4, the levels of those markers significantly improved. Histopathology of the renal tissue showed severe damage of glomeruli, severely congested blood vessels and marked dilatation of Bowman's capsule in group 3 with improvements of these changes in group 4. Conclusion: This study suggests that Extra-virgin olive oil can be used as a cost effective safe anti-oxidative agent in the prevention of Cadmium toxicity.

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Hepatoprotective effect of olive oil and camel milk on acetaminophen-induced liver toxicity in mice

Cited by 19 publications

References 0 publications

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Prophylactic Effect of Camel Milk on Physiological and Biochemical Changes in Ccl4-Intoxicated Rats

Vitamin E is a potent regulator of inflammatory cytokines released during hepatic toxicity in rats

Cytoprotectant and Anti-Oxidant Effects of Olive Oil on Cadmium Induced Nephrotoxicity in Mice

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