Hepatoprotective Effect of Guava (&amp;lt;i&amp;gt;Psidium guajava&amp;lt;/i&amp;gt; L.) Leaf Extracts on Ethanol-Induced Injury on Clone 9 Rat Liver Cells

Hung-Hui, Chen; Wu, Peng; Lo, Diana; Yun-Chieh, Pan; Ming-Chang, Wu

doi:10.4236/fns.2011.29133

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…Studies carried out in clone 9 cells treated with different extracts of the leaves showed that only ethanol and acetone extracts tend to have cytotoxicity effect at high concentrations. Moreover, the ethanol extract showed hepato-protective activity, although the hot-water extract reported greater effect and lower cytotoxicity [ 85 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Díaz‐de‐Cerio

Verardo

Gómez-Caravaca

et al. 2017

IJMS

137

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Today, there is increasing interest in discovering new bioactive compounds derived from ethnomedicine. Preparations of guava (Psidium guajava L.) leaves have traditionally been used to manage several diseases. The pharmacological research in vitro as well as in vivo has been widely used to demonstrate the potential of the extracts from the leaves for the co-treatment of different ailments with high prevalence worldwide, upholding the traditional medicine in cases such as diabetes mellitus, cardiovascular diseases, cancer, and parasitic infections. Moreover, the biological activity has been attributed to the bioactive composition of the leaves, to some specific phytochemical subclasses, or even to individual compounds. Phenolic compounds in guava leaves have been credited with regulating blood-glucose levels. Thus, the aim of the present review was to compile results from in vitro and in vivo studies carried out with guava leaves over the last decade, relating the effects to their clinical applications in order to focus further research for finding individual bioactive compounds. Some food applications (guava tea and supplementary feed for aquaculture) and some clinical, in vitro, and in vivo outcomes are also included.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Díaz‐de‐Cerio

Verardo

Gómez-Caravaca

et al. 2017

IJMS

137

View full text Add to dashboard Cite

show abstract

“…According to reports, in the aforementioned studies, different solvents can be used for the extraction of phenolic compounds from guava leaves, but there is a possibility that these extracts present a risk to consumers. With respect to the toxicity of guava leaf extracts, Chen et al [ 19 ] documented that ethanol and acetone extracts at concentrations greater than 100 μg/mL and 50 μg/mL, respectively, may present cytotoxicity, while aqueous extracts at concentrations lower than 500 μg/mL do not represent cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Phenolic Compounds and In Vitro Radical Scavenging Abilities with Leaf Extracts from Two Varieties of Psidium guajava L.

et al. 2018

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Guava leaf (Psidium guajava L.) extracts are used in both traditional medicine and the pharmaceutical industry. The antioxidant compounds in P. guajava leaves can have positive effects including anti-inflammatory, anti-hyperglycemic, hepatoprotective, analgesic, anti-cancer effects, as well as protecting against cardiovascular diseases. In the present study, phenolic compounds and in vitro antioxidant capacity were measured in extracts obtained with polar and non-polar solvents from leaves of two varieties of guava, Calvillo Siglo XXI and Hidrozac. The quantity of total phenolics and total flavonoids were expressed as equivalents of gallic acid and quercetin, respectively. Hydroxyl radical, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and Oxygen Radical Absorbance Capacity using fluorescein (ORAC-FL) in vitro tests were used to assess the radical scavenging abilities of the extracts. The total phenolics were higher in the aqueous fraction of the variety Calvillo Siglo XXI, while in the Hidrozac variety total phenolics were higher in the acetone and chloroform fractions. Total flavonoids were higher in all fractions in the variety Calvillo Siglo XXI. Total phenolics showed a highly positive correlation for ORAC-FL, and a moderately positive correlation with hydroxyl radicals. Finally, total flavonoids showed a slightly positive correlation for ORAC-FL and hydroxyl radicals. Both varieties of guava leaf extract showed excellent antioxidant properties.

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“…Among the 5 selected polysaccharides, GSPS, CBPS, and YFLPS had the better anticancer activity through tumor immunotherapy ( Figure 3 ). Guava ( Psidium guajava ) shows potential for the treatment of different diseases—for example, it has anti-inflammatory, antidiarrheal, 23 antidiabetic, 24 antihypertensive, antimicrobial, 25 hepatoprotective, 26 antiallergic, 27 and anticancer/antitumor potential. 28 , 29 Recently, guava leaf hexane fraction was found to modulate both PI3K/AKT/mTOR/S6K1 and MAPK signaling pathways, leading to apoptosis through downmodulating proteins that mediate tumor cell survival, proliferation, metastasis, and angiogenesis in PC-3 cells.…”

Section: Resultsmentioning

confidence: 99%

Immune Cell–Conditioned Media Suppress Prostate Cancer PC-3 Cell Growth Correlating With Decreased Proinflammatory/Anti-inflammatory Cytokine Ratios in the Media Using 5 Selected Crude Polysaccharides

Lin

2016

Integr Cancer Ther

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Five different crude polysaccharides from guava seed (GSPS), bitter buckwheat (BBPS), common buckwheat (CBPS), red Formosa lambsquarters (RFLPS), and yellow Formosa lambsquarters (YFLPS) were isolated to treat human prostate cancer PC-3 cells via direct action or tumor immunotherapy. The splenocyte- and macrophage-conditioned media (SCM and MCM) were prepared using individual selected polysaccharides, and then SCM or MCM was further collected to treat PC-3 cells. The relationship between PC-3 cell growth and Th1/Th2 cytokines in SCM as well as proinflammatory/anti-inflammatory cytokine secretion profiles in MCM were delineated. The results showed that all 5 selected polysaccharides did not significantly inhibit PC-3 cell growth via direct action. However, SCM or MCM cultured in the absence or presence of 5 selected polysaccharides significantly (P < .05) inhibited PC-3 cell growth. MCM cultured with 5 polysaccharides dose dependently enhanced their inhibitory effects on the viabilities of PC-3 cells than those cultured without polysaccharides. There was a significant (P < .05) negative correlation between PC-3 cell viabilities and (interleukin [IL]-6 + tumor necrosis factor [TNF]-α)/IL-10 level ratios in the corresponding MCM, implying that macrophages suppress PC-3 cell growth through decreasing secretion ratios of proinflammatory/anti-inflammatory cytokines in a tumor microenvironment.

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Hepatoprotective Effect of Guava (<i>Psidium guajava</i> L.) Leaf Extracts on Ethanol-Induced Injury on Clone 9 Rat Liver Cells

Abstract: ABSTRACT

Cited by 11 publications

References 9 publications

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade

Quantification of Phenolic Compounds and In Vitro Radical Scavenging Abilities with Leaf Extracts from Two Varieties of Psidium guajava L.

Immune Cell–Conditioned Media Suppress Prostate Cancer PC-3 Cell Growth Correlating With Decreased Proinflammatory/Anti-inflammatory Cytokine Ratios in the Media Using 5 Selected Crude Polysaccharides

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