Hepatoprotective effect of Ginkgoselect Phytosome® in rifampicin induced liver injurym in rats: Evidence of antioxidant activity

Naik, Suresh R.; Panda, Vandana

doi:10.1016/j.fitote.2008.02.013

Cited by 91 publications

(47 citation statements)

References 20 publications

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“…Catecholamine undergoes rapid oxidation and the oxidation products cause the necrosis of the cell and contractile failure in the rat heart [7]. CAT, superoxide dismutase, and GP are free radical scavenging enzymes concerned foremost with cellular defence against oxidative damage, O 2 and H 2 O 2 decomposition prior their interaction to form more reactive hydroxyl radical.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, a high production of reactive oxygen species (ROS) may be a unifying mechanism in ischemic injury progression and antioxidants administration may protect against ISP induced cardiac damage. ISP induced myocardial injury is a well-established model used to study the beneficial effect of arrays of drugs on cardiac dysfunction [7,8]. This is because the pathophysiological signs in animals after ISP administration are similar to myofibrillar degeneration, a typical symptom of MI in humans [9].…”

Section: Introductionmentioning

confidence: 99%

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Aqueous root extract of Dicoma anomala Sond ameliorates isoproterenol–induced myocardial infarction in Wistar rats

Balogun¹,

Ashafa²

2016

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aqueous root extract of Dicoma anomala Sond ameliorates isoproterenol–induced myocardial infarction in Wistar rats

Balogun¹,

Ashafa²

2016

Trop. J. Pharm Res

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“…About one-third of world's total population has latent tuberculosis and approximately nine million new cases of active tuberculosis emerge annually resulting in two to three million deaths (Naik & Panda, 2008). Currently used antitubercular chemotherapy includes a combination of three drugs, viz., isoniazid (INH), rifampicin (RMP) and pyrazinamide (PZA).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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Context: Tarvada [Cassia auriculata Linn. (Caesalpiniaceae)] is used against liver ailments in Indian folk medicine, but there is a lack of scientific evidence for this traditional claim. Objective: The present study investigated the protective effect of methanol extract of tarvada (MECA) roots on ethanol and antitubercular drug induced hepatotoxicity in rats. Materials and methods: In the therapeutic model, ethanol (40%, 4 g/kg b.w., p.o.) was administered to rats for 21 days and the intoxicated rats were treated with MECA (300 and 600 mg/kg, b.w.) and silymarin (100 mg/kg, b.w.) for next 7 days. In the prophylactic model, MECA and silymarin were administered simultaneously along with a combination of isoniazid (27 mg/kg, b.w.), rifampicin (54 mg/kg, b.w.) and pyrazinamide (135 mg/kg, b.w.) for 30 days. After the study duration, serum levels of AST, ALT, ALP, total bilirubin, total cholesterol, total protein, albumin were estimated along with hepatic catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and liver histopathology in each group. Results: Administration of tarvada root extract significantly (p50.01 and p50.05) lowered the elevated levels of serum AST, ALT, ALP, total bilirubin, total cholesterol, total protein and restored the abnormal levels of enzymatic antioxidants and MDA in liver due to toxicant administration in a dose-dependent manner. These results were confirmed by histopathological analysis. Discussion and conclusion: Results suggest that tarvada root extract possess potent hepatoprotective activity against ethanol and antitubercular drug-induced hepatotoxicity in rats, which could be due to an inhibition of hepatic metabolizing enzymes and antioxidant activity.

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“…Controversial results concerning the involvement of CYP 1A2 and oxidative stress in tacrine-induced HepG2 cells have been described by other groups [2][3][4]. Since enhanced ROS productions and GSH depletion are major mechanisms involved in tacrine cytotoxicity, application of antioxidants in tacrine-induced HepG2 cells is an appropriate approach for investigating hepatoprotective activity of antioxidant [2,[5][6][7]10,11,31,32]. In this regard, silymarin, a major constituent of Milk thistle extract, has become a remarkable phytochemical to maintain or improve liver functions, and its pharmacological actions were reported for scavenging free radicals, inhibition of lipid peroxidation, and stabilization of cell membranes with its intrinsic antioxidant activities [29].…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells

et al. 2012

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Hepatoprotective effect of Ginkgoselect Phytosome® in rifampicin induced liver injurym in rats: Evidence of antioxidant activity

Cited by 91 publications

References 20 publications

Aqueous root extract of Dicoma anomala Sond ameliorates isoproterenol–induced myocardial infarction in Wistar rats

Aqueous root extract of Dicoma anomala Sond ameliorates isoproterenol–induced myocardial infarction in Wistar rats

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells

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