Hepatoprotective effect of fucoidan isolated from the seaweed Turbinaria decurrens in ethanol intoxicated rats

Selvaraju, M.; Umayaparvathi, S.; Saravanan, R.; Manivasagam, Thamilarasan; Balasubramanian, T.

doi:10.1016/j.ijbiomac.2014.03.042

Cited by 46 publications

(26 citation statements)

References 18 publications

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“…There are some studies regarding the effect of fucoidan on the liver. Clinical studies have shown that oral fucoidan can reduce liver fibrosis and has anti-inflammatory effects in patients with non-alcoholic hepatitis (NAFLD) [17,19,21,22]. In an animal experiment, ALT and AST in the serum increased after ConA-induced liver inflammation in mice, and ALT and AST decreased in a dose-dependent manner after adding different concentrations of fucoidan [27].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of fucoidan in the liver has also been extensively studied. Studies have shown that fucoidan can reduce liver fibrosis and have anti-inflammatory effects in patients with nonalcoholic hepatitis [19][20][21][22]. Fucoidan has been shown to protect the liver from free radical damage in cell and animal experiments on alcoholic hepatitis [23].…”

Section: Introductionmentioning

confidence: 99%

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The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase

Shen

Shih

et al. 2020

Nutrients

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Chronic hepatitis B virus (HBV) infection is a serious public health issue. Vitamin D is involved in various pathophysiological mechanisms as an immune modulator and the deficiency rate of vitamin D is prevalent in chronic liver disease. Fucoidan exerts anti-inflammatory, anticoagulant, antitumor, antimetastatic, and antiangiogenetic effects; however, its effect on the immune responses of HBV patients is unclear. This study investigated how 25(OH)Vitamin D status affected the effectiveness of oligo fucoidan in patients with HBV infection in the immune tolerance phase. Fifty-one patients received oligo fucoidan 4400 mg/day for 48 weeks. Flow cytometry was used to detect T lymphocyte markers (CD3+CD4+, CD3+CD8+, CD4+CD45RO+, CD8+CD45RO+). The levels of white blood cell (WBC), platelets (PLT), and albumin were decreased after 48 weeks of supplementation (p < 0.05). Percentages of CD3+CD8+ and CD8+CD45RO+ cells were decreased after 12 weeks of supplementation (p < 0.05). In patients with adequate vitamin D, HBV-DNA concentrations decreased and the proportion of CD4+CD45RO+ and CD8+CD45RO+ cells increased upon oligo fucoidan supplementation. The HBeAg status of one vitamin D-adequate patient changed from positive to negative at the 12th week of supplementation. The oligo fucoidan may regulate immune effects in patients with HBV infection, and the 25(OH)Vitamin D status might have affected the effectiveness of oligo fucoidan.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase

Shen

Shih

et al. 2020

Nutrients

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“…The rats were divided into three groups (Wistar, GK and GK/fucoidan group) and each group contained 8 rats The rats were housed in a controlled environment, with a temperature of 24±1˚C, and a 12 h light/12 h dark cycle, with light turned on at 7 a.m. The rats were provided with access to standard rat food and water ad libitum, with or without fucoidan at the recommended concentration of 75 mg/kg body weight (14) for 13 weeks, beginning at 6 weeks of age.…”

Section: Methodsmentioning

confidence: 99%

Effects of fucoidan on insulin stimulation and pancreatic protection via the cAMP signaling pathway in vivo and in vitro

Jiang

Mao

et al. 2015

Molecular Medicine Reports

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Diabetes is a global disease, in which pancreatic dysfunction is an important pathological process. In previous years, interest in the biological activities of seaweed has increased. Fucoidan is an extract of the seaweed Fucus vesiculosus, which has been widely investigated. The present study aimed to determine the effects of fucoidan on insulin stimulation and pancreatic protection in vivo and in vitro. Goto‑Kakizaki (GK) rats were provided with free access to standard food, with or without fucoidan, for 13 weeks, following which the body weights, and blood glucose and serum insulin levels of the rats were measured. Wistar rats were used as a control. In addition, the RIN‑5F rat insulin‑secreting cell line was treated with fucoidan in high glucose conditions, following which the dose‑dependent and time‑dependent effects of fucoidan were determined, and the concentration of insulin was measured. Glybenclamide was used as a positive control. In vivo, the body weight and serum insulin levels decreased, whereas blood glucose levels increased significantly in the GK rats, compared with the Wistar control rats. Although, fucoidan did not improve changes in body weight, the increased blood glucose levels were reduced and the decreased serum insulin levels were increased in the GK rats following oral administration of fucoidan. In vitro, fucoidan did not exhibit significant cytotoxicity towards the RIN‑5F cells, and the insulin secretion increased significantly in a dose‑ and time‑dependent manner. Treatment with amylin, an islet amyloid polypeptide and glybenclamide inhibitor, did not inhibit the stimulatory activity of fucoidan. The results of the present study also demonstrated that the concentration of cyclic adenosine monophosphate (cAMP) was significantly increased in the fucoidan‑treated RIN‑5F cells, and this increase was dose‑ and time‑dependent. In addition, treatment with a phosphodiesterase inhibitor, which decreases the degradation of cAMP, significantly increased fucoidan‑induced insulin secretion, whereas treatment with an adenylyl cyclase inhibitor, which decreases the generation of cAMP, significantly decreased fucoidan‑induced insulin secretion. In conclusion, these data indicated that fucoidan may stimulate insulin secretion and provide pancreatic protection via the cAMP signaling pathway, in vivo and in vitro.

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“…The results of the present study strongly suggest that GTE protects against oxidative damage to hepatic tissue by preventing excessive lipid peroxidation and by maintaining serum hepatic marker enzymes, TP, and ALB of alcoholic rats near normal concentrations. [34] described that treated NAFLD patients with EPA reduce serum ALT and AST concentrations when compared with patients who refused EPA supplementation. Interestingly, liver perfusion was also improved by EPA, perhaps reflecting an enhancement of hepatic microcirculatory function.…”

Section: Effects Of Gte and Omega-3 On Liver Injury Biomarkersmentioning

confidence: 99%

Influence of Omega-3 and Green Tea Extract on Alcohol-Induced Liver Injury in Rats

Hussein

Ibrahim

2018

KJAR

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Drinking alcoholic beverages recently is common in many parts of the world, liver is a principal organ that involved in toxic effects of alcohol and it remains a serious health problem globally. Fatty liver (steatosis) was induced in male albino rats by alcohol 40% orally (3.76gm/kgm BW/day) for the period of 4 weeks, then green tea extract (GTE) and omega-3 (OMG-3) fish oil were used as treatments for improvement and investigating their comparison potential role for the next 4 weeks. At the end of the experiment, the rats were fasted overnight, blood samples through the cardiac puncture and liver organ were collected for biochemical and histopathological analysis respectively. Biochemical parameters including: lipid profiles: (total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C), serum malondialdehyde (MDA), liver function tests (LFT): (Serum albumin (ALB), serum total protein (TP), total serum bilirubin (TSB), serum alkaline phosphatase (ALP), serum alanine aminotransferase (ALT), and serum aspartate aminotransferase (AST) and finally hepatic histological changes were also investigated. Alcoholic rats were associated with significant elevation (P<0.05) in the levels of serum TC, TG, LDL-C, MDA, TSB, ALT, AST and ALP, whereas the levels of serum HDL-C and TP significantly (P<0.05) decreased with no significant change (P>0.05) of serum ALB level. treatment of alcohol-fed rats with GTE and OMG-3 oil either alone or in their combination have significant role (P<0.05) in lowering the injury effects of alcohol evidenced by reversing the results obtained on serum lipid profiles, MDA, LFTs and hepatic histological changes after their treatments during the amelioration study. Ethanol consumption impaired hepatic functions, disturbed lipid metabolism, induced hyperlipidemia and increased oxidative stress. Aqueous extracts of GT and OMG-3 oil significantly improved alcohol-induced liver injury through improvement of serum markers of hepatic injury, their hypolipidemic actions and hepatic histologic recovery. Co-treatments of GT+OMG-3 have more protective effect or faster progression against ALD than their treatments alone.

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Hepatoprotective effect of fucoidan isolated from the seaweed Turbinaria decurrens in ethanol intoxicated rats

Cited by 46 publications

References 18 publications

The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase

The 25(OH)Vitamin D Status Affected the Effectiveness of Oligo Fucoidan in Patients with Chronic Hepatitis B Virus Infection with Immune Tolerance Phase

Effects of fucoidan on insulin stimulation and pancreatic protection via the cAMP signaling pathway in vivo and in vitro

Influence of Omega-3 and Green Tea Extract on Alcohol-Induced Liver Injury in Rats

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