2014
DOI: 10.1016/j.ijbiomac.2014.03.042
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Hepatoprotective effect of fucoidan isolated from the seaweed Turbinaria decurrens in ethanol intoxicated rats

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Cited by 46 publications
(25 citation statements)
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“…There are some studies regarding the effect of fucoidan on the liver. Clinical studies have shown that oral fucoidan can reduce liver fibrosis and has anti-inflammatory effects in patients with non-alcoholic hepatitis (NAFLD) [17,19,21,22]. In an animal experiment, ALT and AST in the serum increased after ConA-induced liver inflammation in mice, and ALT and AST decreased in a dose-dependent manner after adding different concentrations of fucoidan [27].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There are some studies regarding the effect of fucoidan on the liver. Clinical studies have shown that oral fucoidan can reduce liver fibrosis and has anti-inflammatory effects in patients with non-alcoholic hepatitis (NAFLD) [17,19,21,22]. In an animal experiment, ALT and AST in the serum increased after ConA-induced liver inflammation in mice, and ALT and AST decreased in a dose-dependent manner after adding different concentrations of fucoidan [27].…”
Section: Discussionmentioning
confidence: 99%
“…The effect of fucoidan in the liver has also been extensively studied. Studies have shown that fucoidan can reduce liver fibrosis and have anti-inflammatory effects in patients with nonalcoholic hepatitis [19][20][21][22]. Fucoidan has been shown to protect the liver from free radical damage in cell and animal experiments on alcoholic hepatitis [23].…”
Section: Introductionmentioning
confidence: 99%
“…The rats were divided into three groups (Wistar, GK and GK/fucoidan group) and each group contained 8 rats The rats were housed in a controlled environment, with a temperature of 24±1˚C, and a 12 h light/12 h dark cycle, with light turned on at 7 a.m. The rats were provided with access to standard rat food and water ad libitum, with or without fucoidan at the recommended concentration of 75 mg/kg body weight (14) for 13 weeks, beginning at 6 weeks of age.…”
Section: Methodsmentioning
confidence: 99%
“…The results of the present study strongly suggest that GTE protects against oxidative damage to hepatic tissue by preventing excessive lipid peroxidation and by maintaining serum hepatic marker enzymes, TP, and ALB of alcoholic rats near normal concentrations. [34] described that treated NAFLD patients with EPA reduce serum ALT and AST concentrations when compared with patients who refused EPA supplementation. Interestingly, liver perfusion was also improved by EPA, perhaps reflecting an enhancement of hepatic microcirculatory function.…”
Section: Effects Of Gte and Omega-3 On Liver Injury Biomarkersmentioning
confidence: 99%