Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Kamil, Noor; Imran-ul-Haque, Hafi z Syed

doi:10.5530/pj.2014.5.3

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Hepatotoxicity which is caused by TB medications can influence the hepatocytes or vasculature and affect the biliary epithelium, but the fundamental component and contributing elements which causes hepatic harm are not known. Brief and asymptomatic expanded transaminase levels can be minor and have non-dynamic harm to mitochondria, cell layers, or different structures of hepatocytes 6 . Furthermore, different studies have been carried out to develop effective ways to reduce the hepatotoxicity of anti-TB drugs, which can be done by either using synthetic drugs or natural botanical products without interfering with their therapeutic actions 7 .…”

Section: Introductionmentioning

confidence: 99%

Curcumin has Curative Effect on Isoniazid-Rifampicin Induced Hepatotoxicity

2023

PJMD

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Background: Anti-tuberculosis drugs-induced hepatotoxicity is associated with oxidative stress. Curcumin is a powerful antioxidant and has been found to protect the liver from the damaging effects of oxidative stress. The study aimed to assess the curative and protective effects of Curcumin against hepatotoxicity induced by anti TB- drugs (Isoniazid-Rifampicin) by using an experimental model of Albino rabbits. Methods: Albino rabbits(n=24) were divided into four groups. Group A was the control group, Group B administered Isoniazid (INH) (50 mg/kg/d) and Rifampicin (RMP) (100 mg/kg) alone, Group C received both INH+RMP and Curcumin (60 mg/kg) before and during induction. Group D received INH (50 mg/kg/d) and RMP (100 mg/kg/d) for 7 days, followed by 7 days of Curcumin (60 mg/kg/d). Biochemical testing and liver morphological histopathology was done for all groups. All values were recorded in mean ± standard deviation. Results: Anti-Tuberculosis drugs increased Alanine Transaminase (ALT), Aspartate Transaminase level (AST), Alkaline Phosphatase level (ALP), Total Bilirubin, and Albumin 62.0±2.5, 172.5±1.0, 128±1.5, 0.80±0.05, 5.00±0.5 respectively and decreased Total protein levels (2.05±1.0). Whereas, Curcumin lowered liver enzymes 37.0±2.8, 126.12±1.5, 90.5±1.0, 0.40±0.01, 3.50±0.5 respectively, and increased levels of total protein (5.00±0.5). Group A exhibited normal liver morphology, whereas, Group B had ballooning degeneration, focal cell necrosis, and liver inflammation. Group C had moderate fatty liver but no centrilobular degeneration or focal cell necrosis and Group D exhibited minor liver inflammation and normal liver morphology. Conclusion: Curcumin was found preventative and therapeutic remedy which can be used for the treatment of hepatotoxicity. Keywords: Curcumin; Hepatotoxicity; Hepatoprotective; Isoniazid; Rifampicin.

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Section: Introductionmentioning

confidence: 99%

Curcumin has Curative Effect on Isoniazid-Rifampicin Induced Hepatotoxicity

2023

PJMD

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“…Ethanolic and water extract of flowers also reported their hepatoprotective activity. The coadministration of antituberculosis drugs with CP has reduced levels of alanine amino transferase, aspartate amino transferase, and bilirubin within the normal range [32].…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

A Review on Phytochemistry and Pharmacological Properties of Milkweed Family Herbs (Asclepiadaceae)

Karale¹,

Karale²

2017

Asian J Pharm Clin Res

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Calotropis procera and Gymnema sylvestre are a perennial shrub and woody climber, respectively, and belonging to the family Asclepiadaceae. They are commonly known as milkweed family herbs. The Calotropis commonly have two species, i.e., C. procera and C. gigantean. All parts of plant exude white milky latex when cut. It has been widely used in traditional medicine due to its pharmacological active compounds found in all parts of plants such as bark, roots, and leaves and especially its latex which exudes from damaged or broken stem and leaves. G. sylvestre an ayurvedic herb came to be known as "destroyer of sugar" because in ancient times Ayurveda physicians observed that chewing a few leaves of G. sylvestre suppressed the taste of sugar. It also reported to possess antidiabetic, antioxidant, and immunomodulatory, antiulcer, and anticancer potential. The gymnemic acid is the main constituent which is responsible for number of pharmacological activities. The present review assembles the data on pharmacognostic and pharmacological potential of C. procera and G. sylvestre.

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A systematic review on the biological evaluation of Calotropis procera (Aiton) Dryand

Abdulrahman

2023

Futur J Pharm Sci

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Background Humans have used plants as a safe and effective medicine for a wide range of ailments ever since the earliest days of civilization. Calotropis procera potential as a treatment for a variety of ailments has been known for quite some time. This xerophytic, upright shrub grows to a height of about 6 m and can be found in the tropics of Africa and Asia. Its parts have been used to cure a variety of ailments, including rheumatism, fever, dysentery, diabetes, malaria, asthma, and many more. Here, we provide a synopsis of the available biological data and discuss the possible ways in which Calotropis procera could be used as a novel platform for the treatment of a wide range of diseases. Main body High antioxidant, antiinflammatory, antianalgesic, antimicrobial, antimalaria, antidiabetic, wound-healing, hepato-protective, nerve-recovery, antiulcer, insecticidal, and anticancer effects have been observed in the latex. The research also found that excessive intake has negative health effects. Conclusion The review discovered that the biological evaluation of C. procera in vitro and in vivo animal models was well documented. Human safety and efficacy, however, have yet to be thoroughly tested, and additional well-designed clinical trials are required to confirm preclinical findings. It is essential to establish a standard dose and assure its safety.

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Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Cited by 3 publications

References 37 publications

Curcumin has Curative Effect on Isoniazid-Rifampicin Induced Hepatotoxicity

Curcumin has Curative Effect on Isoniazid-Rifampicin Induced Hepatotoxicity

A Review on Phytochemistry and Pharmacological Properties of Milkweed Family Herbs (Asclepiadaceae)

A systematic review on the biological evaluation of Calotropis procera (Aiton) Dryand

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