Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide

Wilhelm, Ethel A.; Jessé, Cristiano Ricardo; Roman, Silvane Souza; Nogueira, Cristina W.; Savegnago, Lucielli

doi:10.1016/j.yexmp.2009.03.004

Cited by 52 publications

(44 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Co-administration of LPS and GalN to mice produces lethal liver injury, characterized by intense hemorrhage, inflammatory cells, and necrosis, leading to rapid death (Wilhelm et al 2009). Results of this study demonstrate that curcumin could protect mice against the toxic effect of LPS/GalN as manifested by Fig.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

et al. 2009

View full text Add to dashboard Cite

The effect of curcumin on lipopolysaccharide/D: -galactosamine (LPS/GalN)-induced acute shock model of liver injury was examined in mice. The simultaneous administration of LPS (5-20 microg kg(-1), i.p.) and GalN (700 mg kg(-1), i.p.) markedly increased the serum tumor necrosis factor-alpha (TNF-alpha), glutamic oxaloacetic transaminase/glutamic pyruvic transaminase (GOT/GPT), and massive hepatic necrosis and inflammation, leading to 100% lethality. Pre-administration of curcumin (100 mg kg(-1), i.p.) 3 h before induction with LPS/GalN imparted a large extent of protection against acute elevation in serum TNF-alpha and serum GOT/GPT. Hepatic necrosis and lethality caused by LPS/GalN was also greatly reduced by curcumin treatment. The results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading TNF-alpha production, eventually raising the survival rate of septic-shock-induced mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

et al. 2009

View full text Add to dashboard Cite

show abstract

“…53 As shown in Figure 6, the mice in group a were intravenously injected with D-GalN/LPS (500 mg/kg and 50 µg/kg LPS in saline) for 24 h. H&E staining of normal liver F) and acute hepatitis E). Scale bar: 100 µm.…”

Section: Visualization Of Omentioning

confidence: 99%

Near-Infrared Fluorescence Probe for in Situ Detection of Superoxide Anion and Hydrogen Polysulfides in Mitochondrial Oxidative Stress

et al. 2016

View full text Add to dashboard Cite

H 2 S plays important physiological and pathological roles in cardiovascular system and nervous system. But recent evidences imply that hydrogen polysulfides (H 2 S n ) are the actual signaling molecules in cells. Although H 2 S n have been demonstrated to be responsible for mediating tumor suppressors, ion channels, and transcription factors, more of their biological effects are still need to be elaborated. On one hand, H 2 S n have been suggested to be generated from endogenous H 2 S upon reaction with reactive oxygen species (ROS). On the other hand, H 2 S n derivatives are proposed to be a kind of direct antioxidant against intracellular oxidative stress. This conflicting results should be attributed to the regulation of redox homeostasis between ROS and H 2 S n . Superoxide anion (O 2 •− ) is undoubtedly the primary ROS existing in mitochondria. We reason that the balance of O 2•− and H 2 S n are pivotal in physiological and pathological processes. Herein, we report two near-infrared fluorescent probes Hcy-Mito and Hcy-Biot for the detection of O 2•− and H 2 S n in cells and in vivo. Hcy-Mito is conceived to be applied in mitochondria, and Hcy-Biot is designed to target tumor tissue. Both of the probes were successfully applied for visualizing exogenous and endogenous O 2•− and H 2 S n in living cells and in tumor mice models. The results demonstrate that H 2 S n can be promptly produced by mitochondrial oxidative stress. Flow cytometry assays for apoptosis suggest that H 2 S n play critical roles in antioxidant systems.

show abstract

“…The study confirmed the anticonvulsant action of 3-ASP and the drug's ability to reduce oxidative stress in the pilocarpine model (Wilhelm et al 2009a). Indeed, 3-ASP presented hepatoprotective effects on acute liver injury induced by d-galactosamine and lipopolysaccharide in rats by a mechanism involving its antioxidant activity (Wilhelm et al 2009b).…”

Section: Introductionmentioning

confidence: 99%

3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats

et al. 2010

View full text Add to dashboard Cite

The aim of this study was to investigate the protective effect of 3-alkynyl selenophene (3-ASP) on acute liver injury induced by carbon tetrachloride (CCl(4)) and 2-nitropropane (2-NP) in rats. On the first day of treatment, the animals received 3-ASP (25 mg/kg, p.o.). On the second day, the rats received CCl(4) (1 mg/kg, i.p.) or 2-NP (100 mg/kg, p.o.). Twenty-four hours after CCl(4) or 2-NP administration, the animals were euthanized, and their plasma and liver were removed for biochemical and histological analyses. The histological analysis revealed extensive injury in the liver of CCl(4)-exposed and 2-NP-exposed rats, which was attenuated by 3-ASP. 3-ASP significantly attenuated (1) the increase in plasmatic aspartate and alanine aminotransferase activities and lipid peroxidation levels induced by CCl(4) and 2-NP; (2) the inhibition of δ-aminolevulinic dehydratase activity caused by 2-NP; and (3) the decrease in ascorbic acid (AA) levels and catalase (CAT) activity caused by CCl(4). AA levels and CAT activity remained unaltered in the liver of rats exposed to 2-NP. The protective effect of 3-ASP on acute liver injury induced by CCl(4) and 2-NP in rats was demonstrated.

show abstract

Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide

Cited by 52 publications

References 48 publications

Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

Near-Infrared Fluorescence Probe for in Situ Detection of Superoxide Anion and Hydrogen Polysulfides in Mitochondrial Oxidative Stress

3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats

Contact Info

Product

Resources

About