Hepatoprotective and Immunostimulatory Effect of Ganoderma, Andrographolide and Turmeric Against Aflatoxicosis in Broiler Chickens

Lin

Asian-Australas J Anim Sci

2019

Phytochemicals which exist in various plants and fungi are non-nutritive compounds that exert numerous beneficial bioactive actions for animals. In recent years following the restriction of antibiotics, phytochemicals have been regarded as a primal selection when dealing with the challenges during the producing process in the poultry industry. The selected fast-growing broiler breed was more fragile when confronting the stressors in their growing environments. The disruption of oxidative balance that impairs the production performance in birds may somehow be linked to the immune system since oxidative stress and inflammatory damage are multi-stage processes. This review firstly discusses the individual influence of oxidative stress and inflammation on the poultry industry. Next, studies related to the application of phytochemicals or botanical compounds with the significance of their antioxidant and immunomodulatory abilities are reviewed. Furthermore, we bring up nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor kappa B (NF-κB) for they are respectively the key transcription factors involved in oxidative stress and inflammation for elucidating the underlying signal transduction pathways. Finally, by the discussion about several reports using phytochemicals to regulate these transcription factors leading to the improvement of oxidative status, heme oxygenase-1 gene is found crucial for Nrf2-mediated NF-κB inhibition.

Section: Challenges Confronting Poultry Industry: Oxidative Stress Anmentioning

confidence: 99%

Section: Inseparable Issues: Oxidative Stress and Inflammationmentioning

confidence: 99%

Potential crosstalk of oxidative stress and immune response in poultry through phytochemicals — A review

Lin

Asian-Australas J Anim Sci

2019

“…The polysaccharides purified from G. lucidum are able to regulate immune cell proliferation and cytokine production (Mao et al, 1999;Chen et al, 2004). Dietary supplementation of G. lucidum extract (GLE) in the diet or drinking water enhances the immunity of broilers (AL-Zuhariy & Hassan, 2017;Chen & Yu, 2020). GLE supplementation can ameliorate growth performance in broilers (Ogbe et al, 2008;Ogbe et al, 2009;Sofyan et al, 2012;Liu et al, 2016).…”

Section: Ganoderma Lucidum Extract Regulates Gut Morphology and Micro...mentioning

confidence: 99%

Ganoderma Lucidum Extract Regulates Gut Morphology and Microbial Community in Lipopolysaccharide-Challenged Broilers

Chuang

2022

Braz. J. Poult. Sci.

This study was conducted to investigate the effect of Ganoderma lucidum extract (GLE) on the gut morphology and cecal microbial community of broilers challenged with lipopolysaccharide (LPS). 144 one-day-old unsexed broiler chicks were randomly distributed into four treatments: non-challenged broilers fed a basal diet; LPSchallenged broilers fed a basal diet; LPS challenged broilers fed a basal diet supplemented with 1 mL/L of GLE in the drinking water; and LPS challenged broilers fed a basal diet supplemented with 1.33 mL/L of GLE in the drinking water. Results showed that supplementationwith1.33 mL/L of GLE alleviated intestinal inflammatory gene expression in LPSchallenged broilers (p≤0.05). Supplementation of GLE (1 and 1.33 mL/L) increased the villus height in the jejunum and ileum of LPSchallenged broilers (p≤0.001). Weighted principal coordinate analysis, heat map of species abundance, and microbial function pathway revealed distinct separation between the groups treated with LPS only and LPS in combination with GLE supplementation (1 and 1.33 mL/L). The abundance of the genus Faecalibacterium was increased in the cecal digesta of LPS-challenged broilers receiving GLE(1 and 1.33 mL/L) compared with the LPS challenge-only group (p≤0.001). The growth performance parameter of broilers was positively associated with the abundance of the genus Faecalibacterium in the cecal digesta. In conclusion, GLE supplementation could modulate gut morphology and cecal microbiota composition of broilers under inflammatory challenge.

“…In broilers, dietary supplementation with G. lucidum extract (GLE) improves growth performance and modulates the gut microbiota (Ogbe et al, 2008;Ogbe et al, 2009;Sofyan et al, 2012;Liu et al, 2016;Chen & Yu, 2020). GLE supplementation promotes immunity in broilers (AL-Zuhariy & Hassan, 2017;Chen & Yu, 2020). Dietary supplementation with GLE can modulate gut morphology and microbial composition of broilers under lipopolysaccharide challenge (Chuang & Yu, 2022).…”

Section: Introductionmentioning

confidence: 99%

Ganoderma Lucidum Extract Modulates Cecal Microbiota Community in Broilers under Dextran Sulfate Sodium Challenge During the Starter Phase

Chuang

2023

Braz. J. Poult. Sci.

In this study, we investigated the effects of Ganoderma lucidum extract (GLE) supplementation on the cecal microbiota of broilers challenged with dextran sulfate sodium (DSS) during the starter phase. A total of 32 one-day-old, unsexed broiler chicks were randomly divided into four dietary treatments with eight birds per treatment and reared individually for 14 days (n = 8). The diet treatments were: non-DSS challenge, DSS challenge only, DSS challenge plus 0.5 mL/L GLE, and DSS challenge plus 1 mL/L GLE. The results showed that DSS challenge plus 0.5 mL GLE alleviated inflammatory gene expression in the duodenum of broilers (p≤0.01). The alpha diversity of bacterial species in the cecal digesta increased in the group treated with DSS plus 1 mL/L GLE compared with the DSS challenge-only group (p≤0.01). Principal component analysis and principal coordinate analysis indicated distinct clusters between groups treated with DSS-only and DSS plus GLE (0.5 and 1 mL/L). The abundance of the genera Ruminiclostridium 9, Enterococcus, and Sellimonas increased in the group treated with DSS plus GLE (0.5 and 1 mL/L) compared with the other groups (p≤0.01). Comparative microbial function analysis demonstrated that the immune system was promoted in the group treated with DSS plus GLE (0.5 and 1 mL/L) compared to the DSS challenge-only group (p≤0.001). These results demonstrated that GLE supplementation can modulate the cecal microbial community of broilers under DSS challenge during the starter phase.