Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats

Shankar, N.; Manavalan, R.; Venkappayya, D.; Chellappan, David Raj

doi:10.1016/j.fct.2008.07.010

Cited by 86 publications

(55 citation statements)

References 14 publications

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“…It maintains a stable blood glucose level by taking up and storing glucose as glycogen (glycogenesis), breaking it down to glucose when needed (glycogenolysis) and forming glucose from noncarbohydrate sources such as amino acids (gluconeogenesis). The liver also plays an important role in drug elimination and detoxification and liver damage may be caused by many xenobiotics, such as alcohol and many medicines, malnutrition, infection, and anaemia [24,25]. Liver damage is a widespread disease which, in most cases, involves oxidative stress and is characterized by a progressive evolution from steatosis to chronic hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma [26].…”

Section: Liver and Biomarkers Of Hepatoxicitymentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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Abstract:The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, β-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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Section: Liver and Biomarkers Of Hepatoxicitymentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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“…Consequently, the levels of serum ALT and AST are elevated. SOD and other antioxidant enzymes automatically form a mutually supportive team of defense against ROS (Gowri Shankar et al, 2008). SOD activity being easily inhibited by lipid peroxides or ROS has been suggested (Hsiao et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…However, to our knowledge, no published data documenting hepatoprotective effects of RPL are available. Furthermore, previous reports suggest that effective protection against chronic chemical-induced hepatic injury in vivo is usually associated with antioxidant properties (Hsiao et al, 2003;Gowri Shankar et al, 2008;Zeashan et al, 2009). These results motivate us to investigate the potential hepatoprotective and antioxidant activities of RPL extract.…”

Section: Rubus Parvifolius L (Rpl) a Deciduous Thornymentioning

confidence: 99%

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Gao

Sun

Yang

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl 4 )-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl 4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

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“…The CCl 4 induces the peroxidation of lipids that damage the membranes of liver cells and organelles. This results in the release of ALT that is found outside of the mitochondria of the liver into the circulating blood (Shankar et al, 2008) leading to increasing the levels of liver enzymes (ALT). The rising in ALT activity is almost always due to hepatocellular damage (Ravikumar et al, 2005).…”

Section: Mild Chronic Hepatitismentioning

confidence: 99%

Hepatoprotective Effect of Tofu Processed From Germinated Soybean on Carbon Tetrachloride Induced Chronic Liver Injury in Mice

Liên

Hoang²,

Hanh³

et al. 2016

J Food Health Sci

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Abstract:The hepatoprotective activities of silk tofu made from germinated and non germinated soybeans at different doses of feeding against CCl 4 induced hepatic cell toxicity in mice was investigated in this study. The heptatoprotective activity was analyzed by assessing the ratio of liver weight to body weight (L/B), the levels of serum alanine aminotransferase (ALT), total cholesterols (TC), the hepatic malondehydyde (MDA), protein carbonyl (PC) and vitamin C levels as well as the histopathological analysis of liver tissue. All types of silk tofu significantly reduced the L/B value; ALT activity, total cholesterol, hepatic MDA and PC levels, beside, liver vitamin C content increased compared to CCl 4 intoxicated mice. Silk tofu made from germinated soybeans expressed higher hepatoprotective activity as compared to silk tofu made from non germinated soybeans. Mice fed with silk tofu made from germinated soybeans at the dose of 0.4 g/g body weight/day displayed all biochemical parameters as well as the liver tissue histopathological analysis that were similar to that of normal mice and silymarin treated mice. It was suggested that tofu specially made from germinated soybeans expressed great hepatoprotective effect.

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Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats

Cited by 86 publications

References 14 publications

Hepatoprotective Effects of Mushrooms

Hepatoprotective Effects of Mushrooms

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

Hepatoprotective Effect of Tofu Processed From Germinated Soybean on Carbon Tetrachloride Induced Chronic Liver Injury in Mice

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