Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts

Rao, Battu Ganga; Rao, Yanghui; Talluri, Mallikarjuna Rao

doi:10.1016/s1995-7645(13)60092-9

Cited by 29 publications

(43 citation statements)

References 29 publications

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“…The search of biologically active compounds from medicinal plants has always been of great interest to scientists looking for new sources of useful drugs against different hazardous diseases. Many plant species have been investigated in the search for antioxidants but generally there is still a demand to find more information concerning the antioxidant potential of plant species [18,21,35,36]. Many studies have shown that natural antioxidants in medicinal plants closely related to their biofunctionalities, such as the prevention or suppression of aging and many diseases associated with oxidative stress, cancer, cardiovascular diseases, rheumatoid arthritis, autoimmune diseases and AIDS [37].…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Screening and In-Vitro Antioxidant Activity of Peristrophe paniculata

Srikanth¹,

Devi²,

Kotirataiah³

et al. 2018

Herb Med

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Peristrophe paniculata is one of the traditional medicinal plant have been using in treatment of different diseases. The present study was carried out to provide scientific evidence about its medicinal use and phytochemical variation in different parts (stem, leaves and root) of it. Phytochemical studies were carried out for hexane, ethyl acetate and hydro alcoholic extracts using standard test procedures and antioxidant activity was carried on different free radicals i.e., superoxide, hydroxyl and 1, 1-diphenyl-2-picrylhydrazyl (DPPH). Hydroalcoholic, ethyl acetate and hexane extracts of P. paniculata were found to possess concentration dependent free radical scavenging activity on superoxide, hydroxyl and DPPH free radicals. Qualitative phytochemical screening of P. paniculata extracts revealed the presence of diverse in phytochemical constituents like steroids, terpenoids, flavonoids, alkaloids, glycosides, phenols, tannins and carbohydrates. The extracts of different parts gave negative and positive results for the amino acids, oils and saponins. The selected plant extracts showed concentration dependent percentage of inhibition on tested free radicals along with the standard drug ascorbic acid. The hexane extract of all parts of P. paniculata showed lower activity compared to ethyl acetate and hydroalcoholic extracts. Hydroalcoholic extract showed better activity. The variation in the activity and phytochemical constituents in them maybe due to the compounds present in them either as individually or in mixtures. The further research is need to evaluate more pharmacological activities and in isolation of the bioactive compounds from P. paniculata.

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Section: Discussionmentioning

confidence: 99%

“…The results were showed in mean ± SEM. The Percentage Inhibition and 50% Inhibition Concentration's (IC50) were calculated [18,21]. The each values were studied against blank in every assay of scavenging activity.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 99%

Phytochemical Screening and In-Vitro Antioxidant Activity of Peristrophe paniculata

Srikanth¹,

Devi²,

Kotirataiah³

et al. 2018

Herb Med

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“…If anti-oxidants present in the test compound, a blue to yellow color change occurred due to reaction with DPPH (Rao et al, 2013).…”

Section: In Vitro Free Radical Scavenging Activitymentioning

confidence: 99%

“…Superoxide scavenging activity of the selected extract and its fractions were evaluated as per standard method-induction of superoxide free radical generation by riboflavin, the corresponding reduction by nitroblue tetrazolium and the absorption of light at 560 nm (Rao et al, 2013).…”

Section: In Vitro Free Radical Scavenging Activitymentioning

confidence: 99%

Taxithelium napalense acts against free radicals and diabetes mellitus

Tatipamula

Killari

Ketha

et al. 2017

Bangladesh J Pharmacol

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In this work, Taxithelium napalense ethanolic extract and its fractions were evaluated for the antidiabetic activity in rat based on phytochemical and free radical scavenging properties. The ethanolic extract, fraction IV and V significantly attenuated the blood glucose levels at 600, 200 and 200 mg/kg with 50.0, 33.5 and 42.0% inhibition respectively. The histopathological studies were manifesting the recuperation of damaged cells in liver and pancreas tissues. The outcomes of the present work affirm that the T. napalense has a potency to plummet the overproduction of free radicals and blood glucose levels in the diabetic-induced rat.

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“…Further examination is necessary for isolation and characterization of bioactive molecules which are responsible for hepatic protective and antioxidant activity, what may open a new research topic in our future trials [9].…”

Section: Noni-juicementioning

confidence: 99%