Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves

Huang, Bo; Ban, Xiaoquan; He, Jingsheng; Tong, Jing; Tian, Jun; Wang, Youwei

doi:10.1016/j.foodchem.2009.11.020

Cited by 218 publications

(143 citation statements)

References 20 publications

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“…The rabbits were sacrificed under mild ether anesthesia. Blood samples were collected by heart puncture for evaluating serum biochemical parameters like SGOT, SGPT, ALP and TB [14]. The liver samples were dissected out, washed with normal saline and preserved it in 10 % formalin for histopathological studies to evaluate microscopically the details of hepatic architecture in each group [15].…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Phytochemical Screening and Hepatoprotective Effect of <i>Alhagi maurorum </i>Boiss (Leguminosae) Against Paracetamol-Induced Hepatotoxicity in Rabbits

Rehman¹,

Akhtar²,

Khan³

et al. 2015

Trop. J. Pharm Res

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Section: Hepatoprotective Activitymentioning

confidence: 99%

Phytochemical Screening and Hepatoprotective Effect of <i>Alhagi maurorum </i>Boiss (Leguminosae) Against Paracetamol-Induced Hepatotoxicity in Rabbits

Rehman¹,

Akhtar²,

Khan³

et al. 2015

Trop. J. Pharm Res

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“…From ancient times, man has always used herbs for various liver disorders as a treatment strategy, because natural remedies from traditional medicinal plants have proven to be effective alternative treatments in cases of liver injury. From various studies, it has been found that hepatoprotective effects are directly associated with phytoconstituents (Sabir and Rocha, 2008;Choi et al, 2009;Bhaskar and Balakrishnan, 2010;Huang et al, 2010;Nayak et al, 2011;Rehman et al, 2012;Ibrahim et al, 2013). All around the world, and especially in developing countries, people use traditional herbal medicines; therefore, there is a strong need to develop such a hepatoprotective medicine using natural products that can pass the safety evaluation and screening in the early phase of drug discovery because most toxic compounds are metabolized in the liver (Iwalokun et al, 2006;Adeneye, 2009;Ajiboye et al, 2010;Ahmed et al, 2013;Chanda et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Hussain¹,

Ikram²,

Rehman³

et al. 2014

Turk J Biol

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Malva sylvestris is traditionally used for the treatment of liver diseases, but sufficient pharmacological-based scientific literature is not available online to authenticate its use in liver ailments. We aimed to assess the hepatoprotective effects of Malva sylvestris against paracetamol-induced hepatotoxicity in mice. The extract was concentrated using a rotary evaporator and then desired concentrations of extracts were made by dissolving in normal saline. The standard drug silymarin (100 mg/kg) was used as a reference drug to compare the therapeutic effects of Malva sylvestris. Two different doses of Malva sylvestris (300 and 600 mg/kg) were administered intraperitoneally for 7 consecutive days followed by intraperitoneal administration of paracetamol (250 mg/kg). Paracetamol significantly induced oxidative stress in the liver, ultimately leading to increased serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract of Malva sylvestris significantly reduced the serum levels of these elevated liver enzyme markers in a dose-dependent manner. Histopathological examination of liver tissues also showed hepatoprotective effects of Malva sylvestris in restoring normal functional ability of the liver. The results of our study strongly suggest that the extract of Malva sylvestris has strong hepatoprotective effects against paracetamol-induced liver injury, thereby scientifically affirming its traditional therapeutic role in liver injury.

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“…Since the values of protein carbonyl of skin are lower in the LST group, it suggests that the lotus seed tea has an antioxidative effect against tissue oxidation. In fact, lotus leaf (14,22) or lotus seed extract (23) shows high antioxidative effects in vitro and in vivo. Major antioxidative compounds in lotus seeds include alkaloids, saponins, and phenolics (23).…”

Section: Discussionmentioning

confidence: 99%

Photoprotective Effect of Lotus (Nelumbo nucifera Gaertn.) Seed Tea against UVB Irradiation

Kim

Moon

2015

JFN

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Lotus (Nelumbo nucifera Gaertn.) seed is widely used as a traditional medicine in countries of Asia. Among many functions of the lotus seed, one interesting activity is its skin protection from the sunlight and scar. In this study, we focused on the skin protective property of lotus seed tea against ultraviolet B (UVB) irradiation. Two groups of a hairless mouse model, water as control (water group) and lotus seed tea (LST group), were administrated a fluid drink water for six months. After 6 month of administration, UVB exposure was carried out to both groups for another 3 months. During and after the administration, the skin moisture content and the morphological and histopathological analyses through biopsy were carried out. Prior to UVB irradiation, no significant difference was discovered in the skin moisture content for the water group and LST group (P＜0.05). However, drastic changes were observed after the UVB treatment. The LST group showed a clear evidence of skin protection compared to the control group (P＜0.05). The moisture content, epidermal and horny layer thickness, and protein carbonyl values all revealed that the intake of the lotus seed tea enhanced protection against UVB exposure. As a result, the long-term intake of the lotus seed tea showed the effect of preventing loss of skin moisture, mitigating the formation of abnormal keratinocytes, and contributing to protein oxidation inhibition.

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Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves

Cited by 218 publications

References 20 publications

Phytochemical Screening and Hepatoprotective Effect of <i>Alhagi maurorum </i>Boiss (Leguminosae) Against Paracetamol-Induced Hepatotoxicity in Rabbits

Phytochemical Screening and Hepatoprotective Effect of <i>Alhagi maurorum </i>Boiss (Leguminosae) Against Paracetamol-Induced Hepatotoxicity in Rabbits

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

Photoprotective Effect of Lotus (Nelumbo nucifera Gaertn.) Seed Tea against UVB Irradiation

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