Hepatoprotective and antibacterial effects of extracts from Trichilia emetica Vahl. (Meliaceae)

Germanò, Maria Paola; D’Angelo, Valeria; Sanogo, Rokia; Catania, Stefania; Alma, R.; Pasquale, R. De; Bisignano, Carlo

doi:10.1016/j.jep.2004.09.011

Cited by 51 publications

(29 citation statements)

References 22 publications

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“…The presence of tannins in the root and stem bark was also reported (Burkill, 1997). Our recent studies confirmed the high polyphenolic content of an aqueous extract from the root which could be responsible for the hepatoprotective effects against CCl 4 -induced liver damage in vivo (Germanò et al, 2001) and in vitro (Germanò et al, 2005). Phenolic acids are hydroxylated derivatives of benzoic and cinnamic acids.…”

Section: Introductionsupporting

confidence: 69%

Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl.

Germanò

D’Angelo

Biasini

et al. 2006

Journal of Ethnopharmacology

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Section: Introductionsupporting

confidence: 69%

Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl.

Germanò

D’Angelo

Biasini

et al. 2006

Journal of Ethnopharmacology

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“…Anti-microbial Activity Germano et al 52) have recently reported the presence of limonoids in Trichilia emetica, which can be considered responsible for activity against many clinically, isolated bacterial strains. Limonoids obtained from some Khaya species, showed good antibacterial and antifungal activity.…”

Section: )mentioning

confidence: 99%

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Roy¹,

Saraf

2006

Biological & Pharmaceutical Bulletin

490

276

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The search for limonoids started long back when scientists started looking for the factor responsible for bitterness in citrus which has negative impact on citrus fruit and juice industry worldwide. The term limonoids was derived from limonin, the first tetranortriterpenoid obtained from citrus bitter principles. Compounds belonging to this group have exhibited a range of biological activities like insecticidal, insect antifeedant and growth regulating activity on insects as well as antibacterial, antifungal, antimalarial, anticancer, antiviral and a number of other pharmacological activities on humans. Although hundreds of limonoids have been isolated from various plants but, their occurrence in the plant kingdom is confined to only plant families of order Rutales and that too more abundantly in Meliaceae and Rutaceae, and less frequently in Cneoraceae and Harrisonia sp. of Simaroubaceae. Limonoids are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton. All naturally occurring citrus limonoids contain a furan ring attached to the D-ring, at C-17, as well as oxygen containing functional groups at C-3, C-4, C-7, C-16 and C-17. The structural variations of limonoids found in Rutaceae are less than in Meliaceae and are generally limited to the modification of A and B rings, the limonoids of Meliaceae are more complex with very high degree of oxidation and rearrangement exhibited in the parent limonoid structure. To counter the problem of bitterness in citrus juice and products genetic engineering of citrus to maximize the formation of limonoid glucosides for reducing limonoid bitterness is the focus of recent and future research. Regarding the biological activities of limonoids the investigations are to be directed towards detailed characterization, quantification, and designing a simple as well as versatile synthetic route of apparently important limonoids. Extraction methods too should be optimized; evaluation and establishment of pharmaco-dynamic and kinetic principles, and structure activity relationships should be a key goal associated with limonoids so that they can be safely introduced in our arsenal of pharmaceuticals to safeguard the humanity from the wrath of disease and its discomfort.

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“…Antischistosomal (Sparg et al, 2000) Purgative, antimalarial, antipyretic and against epilepsy and headache (Kerharo and Adam, 1974;Diallo et al, 2003) Antifeeding (Nakatani and Nakanishi, 1993) Hepatoprotective and antibacterial (Germano et al, 2005) Antiplasmodial (El Tahir et al, 1999;Kamanzi et al, 2004) Antitripanosomal (Kamanzi et al, 2004) a The local names are given in Bambara and are in parenthesis; b NA: not available. mation was also obtained from available literature.…”

Section: Part Used Previously Reported Biological Activities and Refementioning

confidence: 99%

Antiplasmodial and GABAA–benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa

Bah

Jäger

Adsersen

et al. 2007

Journal of Ethnopharmacology

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Hepatoprotective and antibacterial effects of extracts from Trichilia emetica Vahl. (Meliaceae)

Cited by 51 publications

References 22 publications

Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl.

Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl.

Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom

Antiplasmodial and GABAA–benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa

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