Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl.

Germanò, Maria Paola; D’Angelo, Valeria; Biasini, T.; Sanogo, Rokia; Pasquale, R. De; Catania, Stefania

doi:10.1016/j.jep.2005.11.029

Cited by 54 publications

(37 citation statements)

References 15 publications

(19 reference statements)

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“…Similar results were achieved in the ascorbate/Fe 2+ -induced lipid peroxidation assay. Afterwards, the phenolic acids content was measured in plasma, before and after β-glucoronidase treatment; the authors observed that the most abundant phenolic acids (caffeic, pcoumaric, protocathecuic, vanillic and galic acids), appeared in higher concentration in plasma in comparison with hydrolyzed phenolic extracts (Germanò et al, 2006). Taking into account the obtained results, it is evident that some phenolic extracts and, therefore, phenolic compounds, need to be metabolized to be biologically active.…”

Section: Bioavailability and Bio-efficacy: Conditioning Factorsmentioning

confidence: 91%

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Martins

Barros

Ferreira

2016

Trends in Food Science & Technology

267

159

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Background: Numerous diseases have been related with free radicals overproduction and oxidative stress. Botanical preparations possess a multitude of bioactive properties, including antioxidant potential, which has been mainly related with the presence of phenolic compounds. However, the mechanisms of action of these phytochemicals, in vivo effects, bioavailability and bio-efficacy still need research.Scope and Approach: The present report aims to provide a critical review on the aspects related with the in vivo antioxidant activity of phenolic extracts and compounds from plant origin.Key findings: Biological functions beyond the human metabolism were discussed, comparing in vivo vs. in vitro studies, as also focusing the conditioning factors for phenolic compounds bioavailability and bio-efficacy. Furthermore, an upcoming perspective about the use of phytochemicals as life expectancy promoters and anti-aging factors in human individuals was provided.Conclusions: Overall, and despite all of those advances, the study of the biological potential of numerous natural matrices still remains a hot topic among the scientific community. In fact, the available knowledge about the responsible phytochemicals for the biological potential, their mechanisms of action, the establishment of therapeutic and prophylactic doses, and even the occurrence of biochemical inter-relations, is considerable scarce.

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Section: Bioavailability and Bio-efficacy: Conditioning Factorsmentioning

confidence: 91%

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Martins

Barros

Ferreira

2016

Trends in Food Science & Technology

267

159

View full text Add to dashboard Cite

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“…Before GC injection, the dried sample was suspended in BSTFA+TMCS 1% for derivatization of the polar compounds. The remaining solution was evaporated to dryness and then submitted to alkaline hydrolysis by adding NaOH (5 M, 30 mL) under nitrogen at room temperature for 4 h, after which the sample was concentrated and the solution was acidified with HCl 12 M (Germano`et al, 2006). The released phenolic compounds were extracted with diethyl ether and dried for derivatization as reported above.…”

Section: Extraction Of Phenolic Compoundsmentioning

confidence: 99%

Gas chromatography–mass spectrometry analysis of phenolic compounds from Carica papaya L. leaf

Canini¹,

Alesiani²,

D’Arcangelo³

et al. 2007

Journal of Food Composition and Analysis

212

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“…[18][19][20] Acidic, basic and enzymatic hydrolysis are the most commonly used methods for the extraction of PAs from natural materials. [21][22][23][24][25] From the scientific literature it is obvious that the most commonly used techniques for the determination of PAs are high-performance liquid chromatography (HPLC) with UV or DAD detection or liquid chromatography coupled with mass spectrometry (LC-MS). [26][27][28][29] Because of the longer sample preparation process for analysis, using gas chromatography with mass spectrometry (GC-MS) in analysis of phenolic compounds is relatively rare, but in comparison with the other methods mentioned, GC-MS offers several advantages, including complete and high-resolution separation, sensitive detection, unambiguous identification and quantitation of a wide range of phenolics (including all isomers) in one chromatographic run.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous GC-MS Determination of Free and Bound Phenolic Acids in Slovenian Red Wines and Chemometric Characterization

Ivanović

Razboršek

Kolar

2016

ACSi

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Several phenolic acids (PAs), caffeic, vanillic, syringic, p-coumaric and ferulic acid, found in Slovenian red wines were studied using gas chromatography and mass spectrometry. For isolation of the PAs from wine samples, solid phase extraction using hydrophilic modified styrene -HLB cartridges was used. The bound PAs were extracted after basic hydrolysis and o-coumaric acid was used as the internal standard. The developed method was validated and the linear concentration range for all analytes was from 1 to 100 mg L -1 with correlation coefficients above 0.999. We show that the method is repeatable (RSD<2%), recoveries were above 96%, and LOD and LOQ values were acceptable. In all of the wine samples tested, caffeic and p-coumaric acid were determined to be the predominant PAs (17-72 mg L -1 ), while other compounds were found in lower concentrations. Principal Component Analysis and Cluster Analysis were used to study differences between wines related towards varieties and Slovenian wine regions. The results demonstrate that variety has more influence on PAs content than wine regions in Slovenian red wines.

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Evaluation of the antioxidant properties and bioavailability of free and bound phenolic acids from Trichilia emetica Vahl.

Cited by 54 publications

References 15 publications

In vivo antioxidant activity of phenolic compounds: Facts and gaps

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Gas chromatography–mass spectrometry analysis of phenolic compounds from Carica papaya L. leaf

Simultaneous GC-MS Determination of Free and Bound Phenolic Acids in Slovenian Red Wines and Chemometric Characterization

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