Hepatoprotective activity of Thymus vulgaris extract against Toxoplasma gondii infection

El-Sayed, Nagwa Mostafa

doi:10.12980/apjtd.7.2017d6-420

Cited by 4 publications

(2 citation statements)

References 26 publications

(27 reference statements)

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“…ese drugs contain phytochemical constituents like phenol, coumarins, monoterpenes, glycosides, flavonoids, alkaloids, and xanthenes, which play a noteworthy role in hepatoprotective activity [10]. Four billion people (about 80% of global population) in the developing countries depend on herbal medicinal products to treat many ailments and the use of herbal remedies has enhanced worldwide over recent years [11][12][13][14]. In Bangladesh, 85% of the total population live in rural areas [15], and about 80% are dependent on herbal medication for their primary healthcare [16,17] due to its fewer side effects as well as lower cost [18].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice

Begum

Papia

Begum

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Background. Polyherbal formulations (PLFs) have been widely used for liver protection, treatment for hepatic dysfunction, and regeneration. They can also enhance appetite and protect the gastrointestinal tract from injury. In spite of the prevalent use, there is a need of scientific evidence on their effectiveness and safety. The objective of the present study was to assess the hepatoprotective effect of polyherbal formulations (commercially available in Bangladesh namely Heptaliv, Holyliv, Icturn, and J-deenar) in CCl4-induced hepatotoxicity in mice. Methods. In this study, Swiss albino mice were treated for 7 days with distilled water or PLFs (2.6 and 5.2 ml/kg body weight/day, per os.) followed by single subcutaneous injection of CCl4 (1 ml/kg body weight, diluted with olive oil in 1 : 1 ratio) on day 8. Twenty-four hours after CCl4 administration, the mice were monitored for the effects of PLFs on liver morphology, biochemical parameters including serum aspartate transaminase (AST), serum alanine transaminase (ALT), alkaline phosphatase (ALP), and total bilirubin. Phenobarbitone-induced sleeping time and histopathology changes in liver tissues were also monitored. Results. CCl4 administration caused significant hepatotoxicity as evidenced by marked elevation in AST, ALT, ALP, and total bilirubin. Phenobarbitone-induced sleeping time and infiltration of inflammatory cells and centrizonal necrosis on histological examination of liver demonstrated hepatic injury after CCl4 administration. However, the administration of Icturn and J-deenar polyherbal formulations at the higher dose significantly decreased the levels of AST, ALT, ALP, and total bilirubin. Moreover, pentobarbitone-induced sleeping time and histopathological analysis also revealed significant improvement as result of treatment with formulations Icturn and J-deenar. Conclusion. Our results confirmed that polyherbal formulations (Icturn and J-deenar) can significantly prevent CCl4-induced hepatotoxicity in mice, demonstrating their protective effect for liver.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice

Begum

Papia

Begum

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…Thymus vulgaris (garden thyme) is a wellknown medicinal plant with anti-inflamma-tory and antioxidant properties. Its ethanolic extract has a hepato-protective activity against T. gondii by improving pathological lesions and liver functions reducing the genotoxic damage (El-Sayed and Ramadan, 2017). Its essential oils especially thymol and carvacol are responsible for its medicinal properties, showing very strong antibacterial, antifungal, and antioxidant activities (Fachini-Queirozet al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Thymus Vulgaris and Myristica Fragrance Houtt (Nutmeg) Ethanolic Extractagainst Toxoplasmosis in Murine Model

Farag

Yahia

Elfeqy

2019

Journal of the Egyptian Society of Parasitology

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Toxoplasma gondii is a globally obligate intra-cellular protozoan zoonotic disease. This study evaluated the efficacy of Thymus vulgaris and Myristica fragrance Houtt (Nutmeg) ethanolic extracts against chronic toxoplasmosis. A total of fifty laboratory-bred male Swiss Albino mice were infected with Me-49 T. gondii strain and divided into five groups G1:non infected/non-treated control, G2:infected/non-treated, G3: infected/treated with Thymus vulgaris extract, G4: infected/treated with nutmeg extract and G5:infected and treated with Spiramycin. Mice were given Thymus and Myristica ethanolic extract 4 days post infection for 14 days then sacrificed 4 weeks after last dose. Brains and livers were dissected out and processed for histopathological examination. Tissue cyst count evaluated the efficacy of extracts. The results showed that mean number of brain cysts was significantly reduced by 47.5% in mice treated with Thymus extract while Myristica extract treated group showed a mild reduction (0.8%). Thymus effect was near to Spiramycin in cyst reduction (47.5% & 48.89%) respectively. Brain and liver lesions in Thymus treated mice showed considerable improvement.

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A Step Forward Towards Food Safety from Parasite Infective Agents

El-Sayed

Ramadan

Masoud

2021

Food Security and Safety

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Hepatoprotective activity of Thymus vulgaris extract against Toxoplasma gondii infection

Cited by 4 publications

References 26 publications

Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice

Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice

Therapeutic Efficacy of Thymus Vulgaris and Myristica Fragrance Houtt (Nutmeg) Ethanolic Extractagainst Toxoplasmosis in Murine Model

A Step Forward Towards Food Safety from Parasite Infective Agents

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