Hepatoprotective activity of Rhus oxyacantha root cortex extract against DDT-induced liver injury in rats

Miled, Hanène Ben; Barka, Zaineb Ben; Hallègue, Dorsaf; Lahbib, Karima; Ladjimi, Mohamed; Tlili, Mounira; Sakly, Mohsen; Rhouma, Khémaïs Ben; Ksouri, Riadh; Tebourbi, Olfa

doi:10.1016/j.biopha.2017.03.063

Cited by 8 publications

(5 citation statements)

References 84 publications

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“…Other studies showed that Rhus species are characterized by gallic acid [20]. Our results corroborated those of Ben miled et al [20] who found high amounts of gallic acid (14.42 mg/g DW) in R. tripartita root cortex extract. This extract showed good antioxidant and hepatoprotective activities in vivo.…”

Section: Quantification Of Individual Phenolic Compoundssupporting

confidence: 92%

“…In addition, apigenin was detected in Rhus species such as R. typhina, R. dentata and R. pentheri [38]. Other studies showed that Rhus species are characterized by gallic acid [20]. Our results corroborated those of Ben miled et al [20] who found high amounts of gallic acid (14.42 mg/g DW) in R. tripartita root cortex extract.…”

Section: Quantification Of Individual Phenolic Compoundssupporting

confidence: 90%

“…Compounds 6, 13, 14, 16 and 18 were positively identified as gallic acid, p-hydroxybenzoic acid, chlorogenic acid, vanillic acid and syringic acid, respectively, by comparing RTs and UV spectra, and further confirmed with MS spectral data of standards. These compounds (without vanillic acid) had also been reported in leaves, stems [11], roots [20] and fruits of R. tripartita [7].…”

Section: Hydroxycinnamic Acids (1 9 10 17 20 and 21)mentioning

confidence: 66%

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Edible Rhus tripartita fruit as source of health-promoting compounds: characterization of bioactive components and antioxidant properties

Abcha

Criado

Salmieri

et al. 2019

Eur Food Res Technol

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The fruits of Rhus tripartita had recently attracted great attention due to its notable therapeutic effects. Their potential effects are attributed to the richness of diverse classes of secondary metabolites. The objective of this research was to access the determination of chemical composition and antioxidant properties of R. tripartita fruit extracts and its partitioned fractions (absolute petroleum ether, 70% aqueous ethanol, absolute ethyl acetate and water). LC-ESI-MS/MS and FTIR-ATR were used to assess the potential of R. tripartita fruits as a source of health-promoting constituents. A total of 38 phenolics, including flavones, flavonols, flavanones, organic acids, hydroxycinnamic acids and hydroxybenzoic acids, 26 of them were reported for the first time in R. tripartita. The main compounds were apigenin7-O-glucoside, apigenin and p-coumaric acid. The FTIR-ATR analysis results revealed the presence of characteristic functional groups such as − OH, C-O, − C = C and C-H of phenolic compounds, carboxylic acids, carbohydrates, lipophilic components and proteins in R. tripartita fruits. Furthermore, the ethyl acetate fraction showed the highest level of phenolic contents and strong antioxidant activities. The present study recommends R. tripartita fruits as source of natural antioxidants which can be used as bioactive ingredient for functional foods and nutraceuticals.

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Section: Quantification Of Individual Phenolic Compoundssupporting

confidence: 92%

Section: Quantification Of Individual Phenolic Compoundssupporting

confidence: 90%

Section: Hydroxycinnamic Acids (1 9 10 17 20 and 21)mentioning

confidence: 66%

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Edible Rhus tripartita fruit as source of health-promoting compounds: characterization of bioactive components and antioxidant properties

Abcha

Criado

Salmieri

et al. 2019

Eur Food Res Technol

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“…It has been demonstrated that the presence of DDT and its metabolites in animal tissues causes oxidative stress and mitochondrial damage [43][44][45][46][47][48], whereas few data, often controversial, are available on the effects of these substances on MT expression and synthesis. A study performed by Ben Miled and coworkers [49] showed an increase in MT content in hepatocytes of rats receiving a single intraperitoneal injection of 100 mg DDT/kg body weight (bw). In kidneys and testes of rats receiving the same DDT dose for ten days, MT content significantly decreased [45,46].…”

Section: Metallothioneins and Ddt Metabolitesmentioning

confidence: 99%

Exposure to Dichlorodiphenyldichloroethylene (DDE) and Metallothionein Levels in Rats Fed with Normocaloric or High-Fat Diet: A Review

Migliaccio

Lionetti

Putti

et al. 2020

IJMS

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The growing number of studies on metallothioneins (MTs), cysteine-rich metal-binding proteins, have been disclosing new functions of these proteins. Thanks to their inducibility, they were considered to play a pivotal role in regulating trace metals homeostasis and in detoxification from heavy metals; nowadays, it is known that they are involved in various physiological and pathological processes, such as regulation of apoptosis, elimination of free radicals, and protection of nucleic acids against toxic insults. MT induction has been demonstrated following stress factors other than heavy metals, such as endocrine-disrupting chemicals, insecticides, and herbicides. However, retrieved data are often controversial: in some cases, xenobiotics elicit MT expression and synthesis; under different conditions, they lead to a decrease in cellular MT content. This review describes the MT response to dichlorodiphenyltrichloroethane (DDT) contamination in mammalian tissues. In particular, attention focuses on changes in MT expression, synthesis, and localization in rat liver, kidneys, and testes following oral administration of dichlorodiphenyldichloroethylene (DDE), the main metabolite of DDT, under normal dietary conditions or in combination with a high fat diet potentially able to increase the cellular uptake of this lipophilic pesticide. The potential connection between MT expression and synthesis, lipophilic substances and trace metals availability is also discussed.

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“…These results strongly suggest that treatment with ethyl acetate extract normalizes various biochemical parameters and protects the liver against DDT-induced oxidative damage in rats and thus help in evaluation of traditional claim on this plant. 82…”

Section: Rhus Oxyacanthamentioning

confidence: 99%

Hepatoprotective Activity of Some Medicinal Plants: A Review

Hassan¹,

Veerakumar²,

Naseer³

et al. 2019

Int Res J Pharm

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Liver is an essential organ. Its plays a main function in metabolism and excretion of xenobiotics from the body. Moreover it is also coping with the metabolism and excretion of medicine and other xenobiotics from the frame there with the aid of supplying safety towards foreign substances by using detoxifying agents and putting them off. The most important capabilities of the liver are carbohydrate, protein, fat metabolism and detoxification, secretion of bile and storage of vitamins. In this examine, on line databases together with web of Science, Pub Med, Scopus, and Science Direct were looked for papers. Liver illnesses are first rate problem in worldwide. Liver damage or liver disorder is a major fitness troubles those demanding situations no longer most effective health care professionals but also the pharmaceutical industry and drug regulatory companies. Liver disease (Hepatic disease) is a term that impacts the cells, tissues, systems or factures of the liver. Liver cell harm resulting from various toxic chemical compounds (along with antibiotic , chemotherapeutic retailers, thioacetamide and paracetamol and so forth.), excessive alcohol intake and microbes are nicely studied. A number of natural tablets show promising hepatoprotective activities in acute and chronic liver damage. In medication the natural products play an essential role because of their protection, efficacy and price effectiveness. Medicinal plants might also function as vital source of doubtlessly useful for the development of effective therapy to fight several liver troubles. In this review we centred on the number of medicinal plants for protective effect in liver diseases.

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Hepatoprotective activity of Rhus oxyacantha root cortex extract against DDT-induced liver injury in rats

Cited by 8 publications

References 84 publications

Edible Rhus tripartita fruit as source of health-promoting compounds: characterization of bioactive components and antioxidant properties

Edible Rhus tripartita fruit as source of health-promoting compounds: characterization of bioactive components and antioxidant properties

Exposure to Dichlorodiphenyldichloroethylene (DDE) and Metallothionein Levels in Rats Fed with Normocaloric or High-Fat Diet: A Review

Hepatoprotective Activity of Some Medicinal Plants: A Review

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