Hepatoprotective activity of methanolic extract of Terminalia coriacea leaves

Patel, Jitendra; Reddy, A V Gurava; Kumar, Girish; Satyasai, D; Bajari, B.; Nagarjuna, V.

doi:10.5958/0974-360x.2017.00232.3

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alkaloids, flavonoids, steroids, triterpenoids, saponins, tannins, glycosides, and phenolic 7 Phyllanthus Fraternus Phenolic and flavonoid content 27 Pavetta Indica LINN Flavonoids and their glycosides, alkaloids, sterols, phenolics, lignins, terpenoids, coumarins,saponins,phenols 28 Mimosa Pudica Flavonoids, glycosides, terpinoids, alkaloids, phenol and tannin 10 Terminalia coriacea β -Sitosterol, Stigmasterol, 1H-Inden-1-one,2,3-dihydro-3,3,5,6,-tetramethyl, nhexadecanoic acid, flavonoids and tannins 3 Bambusa Bambos Flavonoids, steroidal alkaloids, etc 11 Rosa Canina Flavonoids, phenolic acids, tannins, carotenoids 12 Garcinia Pedunculata Flavonoids, saponins, glycosides, steroids, alkaloids and phenols 13 Tetrapleura tetraptera Flavonoid,polyphenols,flavanol 29 Feijoa sellowiana polyphenols 15 ISSN: 2250-1177…”

Section: Cynara Scolymusmentioning

confidence: 99%

“…Ayurveda a time honoured Indian system of medical practice has multitude proven formulations for the treatment of liver diseases. The plants which protect the liver contain variety of active constituents like flavonoids, glycosides, monoterpenes, coumarins, lignans, essential oil, carotenoids, organic acids, alkaloids and xanthene 3 .Here this paper reviews some incredible plants for their hepatoprotective activity taken from various documented literature from the period of 2011-2021.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Plants with Remarkable Hepatoprotective Activity

Meshack

Gupta

2022

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Liver being vulnerable to exogenous substances makes disease associated with it a matter of worldwide concern. Several research thus focus on hepatoprotection .Preventive and therapeutic activity of plants as a hepatoprotective agent is a topic of interest for researchers. Hepatotoxic agents like carbon tetrachloride, paracetamol, isoniazide etc. increase the serum biomarkers of liver where ALT is more specific than AST in detecting liver injury. Drug-induced liver injury (DILI) wherein more than 900 drugs have been implicated in causing liver injury. Plant phenolics include simple phenols, phenolic acids, coumarins, lignans, flavonoids, diaryl-alkanoids, stilbenoids, proanthocyanins, tannins, and anthocyanins some alkaloids. The greater the content of alkaloids, flavonoids, and saponins in an extract, the higher the hepatoprotective activity possessed by the extract. This paper reviews some plants documented between the periods of 2011-2021 with remarkable heptoprotective activity and discusses the various hepatotoxic agents used, its mechanism and hepatoprotective agents present in the specific plant. Keywords: Hepatoprotective plants, flavonoids, saponin, alkaloids,hepatotoxicity, drug induced liver injury, hepatotoxic agents

show abstract

Section: Cynara Scolymusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review of Plants with Remarkable Hepatoprotective Activity

Meshack

Gupta

2022

J. Drug Delivery Ther.

View full text Add to dashboard Cite

show abstract

“…In traditional medicine, the plant is used as cardiac stimulant and to treat atonic diarrhea, callous ulcers, and inflammatory conditions [1, 2]. Recent pharmacological investigations on the methanolic extract of T. coriacea leaves revealed antinociceptive [3], wound healing [4], anticonvulsant [5], anti-ulcer [6], and hepatoprotective potentials [7]. Phytochemical studies had revealed the presence of bioactive compounds such as flavonoids like apigenin, kaempferol, luteolin, myricetin, quercetin, ru tin [6], 1H-inden-1-one,2,3-dihydro-3,3,5,6,-tetramethyl; levoglucosan; neophytadiene; phytol; hexadecanoic acid; n-hexadecanoic acid; stigmasterol; ß-sitosterol [8]; betulic acid, arjunic acid, arjunolic acid, arjunetin, ellagic acid [9], gallic acid, procyanidin B 1 , B 2 , and B 3 , resveratrol, tyrosine [10]; raffinose; 1,2-benzene dicarboxylic acid; undecanoic acid; (2-propyl-1,3-dioxolan-2-yl)acetic acid; 2,2-dimethyl propane, and octadecatrienoic acid [11].…”

Section: Introductionmentioning

confidence: 99%

Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models

et al. 2018

View full text Add to dashboard Cite

Objective: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. Materials and Methods: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett’s multiple comparison test. Results: The test extract at doses of 125 and 250 mg/kg decreased paw volume and wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed a response comparable to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg, whereas the effect of 500 mg/kg of the extract was comparable to that of aspirin 100 mg/kg (p < 0.01). The extract of T. coriacea at 500 mg/kg induced the most significant (p < 0.01) effect on wet weight of granulomatous tissue. Conclusion: The methanolic extract of T. coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti- edematogenic, antitransudative, and antiproliferative properties of T. coriacea.

show abstract