Hepatoprotective activity of Gundelia tourenfortii

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

“…Then the liver was fixed in bouin's solution (mixture of 75 mL of saturated picric acid, 25 mL of 40% formaldehyde and 5 mL of glacial acetic acid) for 12 hrs, then embedded in paraffin using conventional methods [11]. They were cut into 5 毺m thick sections and stained using haematoxylin-eosin dye and finally mounted in di-phenyl xylene.…”

“…The section was observed under microscope for any histopathological changes. The liver pathology score was calculated as described by Jamshidzadeh et al [12] . Histological damage was expressed using the following score system: 0= no visible cell damage; 1= focal hepatocytes damage on <25%-50% of the tissue; 3= extensive, but focal hepatocytes lesion; 4= global hepatocytes necrosis.…”

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

“…Carbon tetrachloride-induced hepatic injury is commonly used as an experimental method for the evaluation of hepatoprotective drugs or medicinal plant extracts (Jamshidzadeh et al, 2005). Generally, the extent of hepatic damage is assessed by histopathological evaluation and the level of cytoplasmic enzymes released into the circulation (Plaa and Charbonneau, 1994).…”

Screening of some Traditionally Used Plants for Their Hepatoprotective Effect

“…Intraperitoneal injection seems to be the most commonly used method for carbon tetrachloride administration due to the ease of handling and rapid onset of action. Rats are usually a popular experimental animal model and the reported doses were 3 ml/kg (Jamshidzadeh et al, 2005), 2.5 ml/kg (Sen et al, 1993;Nishigaki et al, 1992), 2 ml/kg (Channabasavaraj et al, 2008), 1.5 ml/kg (Bhadauria et al, 2009), 1.25 ml/kg (Rafatullah et al, 2008) or 0.5 ml/kg (Rao et al, 1993). In most cases, carbon tetrachloride is diluted with oils (1:1).…”