Screening of some Traditionally Used Plants for Their Hepatoprotective Effect

Alqasoumi, Saleh I.; Abdel-Kader, Maged S.

doi:10.5772/29819

Cited by 2 publications

(1 citation statement)

References 132 publications

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“…Traditionally, whole plant is used in fever, stomachic, worms, blood purification, asthma, dropsy, snake bite and as cardio tonic (Silori et al 2005;Quattrocchi 2012). It also possesses hepatoprotective, antimicrobial and antibacterial properties (Alqasoumi and Abdel-Kader 2012;Bissa 2015) and high nutraceutical value (Kamboj 2000). Although, E. foliata is cultivated and harvested to a limited scale on a commercial basis in Gujarat (Gavali and Sharma 2004), but over exploitation, extensive habitat destruction, very slow growth rate, poor regeneration, grazing and other anthropogenic pressures have caused tremendous reduction in its natural populations.…”

Section: Introductionmentioning

confidence: 99%

Molecular analysis of genetic diversity and population genetic structure in Ephedra foliata: an endemic and threatened plant species of arid and semi-arid regions of India

Meena

Singh

Mahar

et al. 2019

Physiol Mol Biol Plants

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Studies on the genetic diversity and structure in endangered and threatened species are of utmost importance to design and promote effective conservation and management programs. Ephedra foliata, an endemic and threatened species growing naturally in arid and semi-arid regions of north western India, was investigated to estimate genetic variability and population structure using intersimple sequence repeats (ISSR) and directed amplification of mini-satellite DNA (DAMD) markers. Twenty-five (ISSR 15; DAMD 10) markers produced 449 fragments, of which 382 were polymorphic in nature, revealing 84.59% polymorphism. ISSR markers revealed higher levels of polymorphism, polymorphic information content, marker index, diversity index and effective multiplex ratio than DAMD markers. Higher values of polymorphism, genetic diversity and Shannon information index at species level than at population level revealed that E. foliata possess high genetic diversity. AMOVA revealed much higher variance within populations than among the populations. The three clustering approaches viz., UPGMA, PCoA, and STRUCTURE, grouped the eleven investigated populations into two clusters revealing two genetic populations and the patterns of clustering of populations was in accordance with their geographic distribution, suggesting that these populations have evolved in response to their local environments. The high level of genetic differentiation (G ST = 0.31) and moderate gene flow (N m = 1.11) among populations could be due to geographic isolation, regional climatic conditions, over-exploitation and improper seed setting. To the best of our knowledge, this study is the first endeavour to estimate genetic diversity and population structure of E. foliata using molecular markers.

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Section: Introductionmentioning

confidence: 99%

Molecular analysis of genetic diversity and population genetic structure in Ephedra foliata: an endemic and threatened plant species of arid and semi-arid regions of India

Meena

Singh

Mahar

et al. 2019

Physiol Mol Biol Plants

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Assessment of Anti-Hepatotoxic Effect of Bahuinia tomentosa Linn against Paracetamol induced Hepatocellular Damage In Albino Mice

Jeyaraj

Balaraman²,

Murugesan

et al. 2023

RJPT

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In today’s modern world the chemical induced hepatotoxicity is one huge threat to human life, even the drugs which have easy accessibility and availability are also produces side effects, when they are used irrationally, so the need for antidote from herbal industry is a common factor. Bauhinia tomentosa Linn belongs to fabaceae, considered as one such potential agent which constitutes wide range of chemical compounds which has therapeutic as well as antidote effect. In this study Bahuinia tomentosa Linn was extracted with ethyl alcohol and the prepared ethanolic extract was evaluated for its hepato protective effect against Acetaminophen induced hepato toxicity in albino mice. The biochemical estimation, histo pathological studies are served as index for the assessment of hepatoprotective activity. Modification in body and liver weight, proteins, levels of biomarkers, antioxidant enzymes along with histopatological variations of extract treated groups were compared with standard hepatoprotective drug silymarin. Marked hepatoprotective activity was noticed in extract treated groups in dose dependent manner. The study results revealed the antihepatato toxic effect of Bauhinia tomentosa Linn and recommended as an excellent natural source of drug in the treatment of acetaminophen induced hepatotoxicity.

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Screening of some Traditionally Used Plants for Their Hepatoprotective Effect

Cited by 2 publications

References 132 publications

Molecular analysis of genetic diversity and population genetic structure in Ephedra foliata: an endemic and threatened plant species of arid and semi-arid regions of India

Molecular analysis of genetic diversity and population genetic structure in Ephedra foliata: an endemic and threatened plant species of arid and semi-arid regions of India

Assessment of Anti-Hepatotoxic Effect of Bahuinia tomentosa Linn against Paracetamol induced Hepatocellular Damage In Albino Mice

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