Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity

Parameswari, S Angala; Chetty, C. Madhusudhana; Chandrasekhar, K. B.

doi:10.4103/0974-8490.118828

Cited by 25 publications

(13 citation statements)

References 20 publications

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“…The effect of extract was comparable with a standard drug, Liv 52. The biochemical effects were further confirmed by histological results [95].…”

Section: Hepato- Nephro-and Dermato-protective Effectsmentioning

confidence: 59%

“…Orally administered dose ranged from 50-2000 mg/kg of extract did not produce any significant changes in the autonomic or behavior responses in rats [56].In acute oral toxicity studies, the Ficus religiosa extract treated rats were observed for mortality up to 48 hrs. There was no mortality or any signs of behavioral changes observed after oral administration of methanol extract up to 5000 mg/kg body weight [95].…”

Section: Toxicitymentioning

confidence: 84%

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Pharmacology of Ficus religiosa- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Chemical analysis showed that Ficus religiosa contained tannins, phenols, saponins, sugars, alkaloids, methionine, terpenoids, flavonoids, glycosides, proteins, separated amino acids, essential and volatile oils and steroids. Previous pharmacological studies revealed that Ficus religiosa possessed antimicrobial, anti-parasitic, anti-Parkinson's, anticonvulsant, anti-amnesic, anticholinergic, antidiabetic, antiinflammatory, analgesic, cytotoxic, anti-ulcer, wound healing, antioxidant, anti-asthmatic, reproductive, hepato-, nephro-and dermato-protective effects. The current review highlights the chemical constituents and pharmacological effects of Ficus religiosa.

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“…The effect of extract was comparable with a standard drug, Liv 52. The biochemical effects were further confirmed by histological results [95].…”

Section: Hepato- Nephro-and Dermato-protective Effectsmentioning

confidence: 59%

Section: Toxicitymentioning

confidence: 84%

Pharmacology of Ficus religiosa- A review

Al-Snafi¹

2017

IOSRPHR

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“…[ 35 ] Others include gastroprotective effects of N. officinale ,[ 36 ] antimicrobial effects of Aloe, Cleome , and Ipomoea , spp.,[ 36 37 38 ] and hepatoprotective effects of Ficus , Kalanchoe , Momordica , and Rhus spp. [ 39 40 41 42 ]…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants used by traditional healers in Sangurur, Elgeyo Marakwet County, Kenya

Kigen¹,

Kipkore²,

Wanjohi³

et al. 2017

Phcog Res

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Background:Although herbal medical products are still widely used in Kenya, many of the medicinal plants used by traditional medical practitioners (TMPs) have not been documented, despite several challenges that are now threatening the sustainability of the practice.Objective:To document the medicinal plants and healing methods used by TMPs in a region of Kenya with several recognized herbalists for potential research.Materials and Methods:Semi-structured interviews, group discussions, and direct observations were used to collect ethnopharmacological information. The participant's bio-data, clinical conditions treated, methods of treatment, medicinal plants used, methods of preparation and administration, and dosage forms were recorded.Results:A total of 99 medicinal plants and 12 complementary preparations employed in the treatment of 64 medical conditions were identified. The most widely used plant was Rotala tenella which was used to treat nine medicinal conditions; seven each for Aloe tweediae and Dovyalis abyssinica; and six each for Basella alba and Euclea divinorum. The plants belonged to 55 families with Fabaceae family being the most frequently used (10), followed by Apocynaceae and Solanaceae, each with six species, respectively. We identified plants used to determine the sex of an unborn baby and those used to treat several conditions including anthrax and cerebral malaria and herbs used to detoxify meat from an animal that has died from anthrax. Of special interest was R. tenella which is used to prevent muscle injury.Conclusions:We have documented several plants with potential therapeutic effects. Further research may be conducted to determine their efficacy.SUMMARY The medicinal plants used by traditional healers in a community which still practices herbal medicine in Kenya were documented. A total of 99 medicinal plants and 12 complementary preparations employed in the treatment of 64 medical conditions were identified. Further research may be carried out in order to determine their therapeutic efficacies. Abbreviations Used: Fic: Informant consensus factor, Nur: Number of use reports in each category, Ns: Number of reported species, TMPs: Traditional medical practitioners.

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“…Ficus religiosa L. (Moraceae) (Parameswari et al. 2013 ), Bacopa monnieri L. (Composite) (Evan et al. 2016 ), Tamarix gallica L. (Tamaricaceae) (Urfi et al.…”

Section: Drug-induced Liver Injuryunclassified

Molecular mechanism and research progress on pharmacology of traditional Chinese medicine in liver injury

Zhang

Wang

Zhong

et al. 2018

Pharmaceutical Biology

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Context: Liver disease is a common threat to human health, caused by a variety of factors that damage the liver. Recent studies have shown that active ingredients (for example: flavonoids, saponins, acids, phenols, and alkaloids) from Traditional Chinese Medicine (TCM) can have hepatoprotective benefits, which represents an attractive source of drug discovery for treating liver injury.Objective: We reviewed recent contributions on the chemically induced liver injury, immunological liver damage, alcoholic liver injury, and drug-induced liver injury, in order to summarize the research progress in molecular mechanism and pharmacology of TCM, and provides a comprehensive overview of new TCM treatment strategies for liver disease.Materials and methods: Relevant literature was obtained from scientific databases such as Pubmed, Web of Science. and CNKI databases on ethnobotany and ethnomedicines (from January 1980 to the end of May 2018). The experimental studies involving the antihepatic injury role of the active agents from TCM and the underlying mechanisms were identified. The search terms included ‘liver injury’ or ‘hepatic injury’, and ‘traditional Chinese medicine’, or ‘herb’.Results: A number of studies revealed that the active ingredients of TCM exhibit potential therapeutic benefits against liver injury, while the underlying mechanisms appear to contribute to the regulation of inflammation, oxidant stress, and pro-apoptosis signaling pathways.Discussion and conclusions: The insights provided in this review will help further exploration of botanical drugs in the development of liver injury therapy via study on the effective components of TCM.

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Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity

Cited by 25 publications

References 20 publications

Pharmacology of Ficus religiosa- A review

Pharmacology of Ficus religiosa- A review

Medicinal plants used by traditional healers in Sangurur, Elgeyo Marakwet County, Kenya

Molecular mechanism and research progress on pharmacology of traditional Chinese medicine in liver injury

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