Hepatoprotective activity of Erythrina × neillii leaf extract and characterization of its phytoconstituents

Bakr, Riham O.; Fayed, Marwa A. A.; Fayez, Ahmed M.; Gabr, Salma K.; El-Fishawy, Ahlam M.; El-Alfy, Taha S.

doi:10.1016/j.phymed.2018.09.231

Cited by 10 publications

(7 citation statements)

References 30 publications

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“…The flavonoids identified belonged to four classes—flavanones, flavones, flavonols and chalcones—and showed both C‐ and O‐ glycosylation, in addition to the free aglycones. C ‐glycosides were identified by their fragmentation product ions [M − H − 120] − and [M − H − 90] − (Bakr et al, 2019), whereas, O‐ glycosides exhibited the products ions [M − H − 162] − and [M − H − 132] − owing to loss of hexose and pentose residues, respectively (Bakr et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…They detected erythratine, as well as other Erythrina alkaloids with free hydroxyl groups for instance erysodine and erysovine, with adequate sensitivity without TMS derivatization. In our study, alkaloids, namely erythraline, erythratine, erysotrine, crystamidine and erythratine benzoate, were tentatively characterized by their fragmentation pattern which showed significant peaks at [M] + , [M − 15/M − CH 3 ] + , [M − 31/M − OCH 3 ] + , [M − 33/M − OCH 5 ] + , [M − 58/M − C 3 H 6 O] + , [M − 71/M − C 4 H 7 O] + , [M − 72] + , [M − 84/M − C 5 H 8 O] + and [M − 85] + (Bakr et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

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Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

AbouZeid,

Hussein,

Salama

et al. 2023

Biomedical Chromatography

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Erythrina bidwillii Lindl., Leguminosae, constitutes a valuable crop for horticulture and medicine; however, it is rarely investigated. Menopause is a crucial transitional period in women’s health. Women worldwide consider the use of phytoestrogens as a safe hormone replacement therapy to alleviate detrimental menopausal symptoms. Thus, the discovery of novel phytoestrogens is highly demanded. The present study aimed to investigate, for the first time, the metabolomic profile and the estrogenic potential of E. bidwillii Lindl. leaf. Ultra‐performance liquid chromatography–electrospray ionization‐tandem mass spectrometry and gas chromatography–mass spectrometry metabolite profiling revealed the prevalence of alkaloids, flavonoids, isoflavonoids and fatty acids. Additionally, five erythrinan alkaloids, cristanine A (1), 8‐oxoerythraline (2), (+)‐erythrinine (3), (+)‐erythraline (4) and 8‐oxoerythrinine (5), along with the isoflavonoid genistin (6), were isolated. Erythrina bidwillii leaf extract exhibited significant in vivo estrogenic, anti‐osteoporotic, anti‐hyperlipidemic, hepatoprotective, and nephroprotective activities, utilizing ovariectomized rat model. Moreover, ethyl acetate and hexane fractions possessed significant in vitro estrogeic potential on MCF‐7 cell lines. An in silico study of the isolated metabolites revealed that (+)‐erythrinine (3) and 8‐oxoerythrinine (5) exhibited the highest affinity for ERα and ERβ, respectively, modeling them as potential estrogenic lead metabolites. Therefore, E. bidwillii leaf could be employed as promising hormone replacement therapy for postmenopausal women after thorough clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

AbouZeid,

Hussein,

Salama

et al. 2023

Biomedical Chromatography

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“…Additionally, creatinine and urea were evaluated according to Jacobs et al and Creno et al (Jacobs et al 1991;Creno et al 1970). The inflammatory mediators; TNF-α, IL-1β and IL-6, were assessed using an ELISA kits (Hycult Biotechnology, USA) (Bakr et al 2019)…”

Section: Biochemical Parameters Analysismentioning

confidence: 99%

LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of Bignonia binata leaves against carbon tetrachloride-induced injury in rats

Samy

Hamed

Mahmoud

et al. 2021

Natural Product Research

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The chemical profiling of the main phytoconstituents of total ethanolic extract (TEE) and its different fractions of Bignonia binata leaves was dereplicated using liquid chromatographyhigh resolution-electrospray ionization-mass spectrometry (LC-HR-ESI-MS), revealed the presence of various classes of secondary metabolites; 8 phenylethanoids, 2 flavonoidal glycosides and 2 iridoids. Moreover, the hepatoprotective and nephroprotective activities of the TEE and its different fractions were investigated in CCl 4 -intoxicated rats and were compared with those of silymarin-treated group, revealing the highest potency of the EtOAc group, followed by the aqueous one in improving the CCl 4 -induced alterations in several biochemical parameters. Besides, EtOAc and aqueous fractions exhibited the most inhibition of CCl 4 -induced inflammatory mediators and improving the changes in the histopathological structures of the liver and kidney. Additionally, the EtOAc fraction demonstrated the highest total phenolic content, while TEE showed the highest amount of total flavonoid content.

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“…The Erythrina genus (Fabaceae), represented by about 130 species, is distributed mainly in tropical and subtropical areas . This genus has attracted attention for its broad spectrum of biological activities and its rich flavonoid and alkaloid content .…”

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confidence: 99%

“…1 This genus has attracted attention for its broad spectrum of biological activities and its rich flavonoid and alkaloid content. 2 Erythrina lysistemon Hutch., known as the common coral tree, is cultivated in Egypt as an ornamental plant. 3 It is a deciduous tree, growing up to 12 m tall 4 with a spreading crown and brilliant red flowers.…”

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confidence: 99%

Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon

et al. 2023

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The roots of Erythrina lysistemon, growing in Egypt, yielded 24 flavonoid compounds, including 17 pterocarpans, two isoflavanones, one flavanone, two isoflavans, one 2-arylbenzofuran, and an isoflava-3-ene. Nine pterocarpans have not been reported previously (7–9, 11–14, 19, and 20), and 11 are reported here for the first time from this species. Structures were established using HRESIMS, NMR, and circular dichroism techniques. Selected compounds were tested for their ability to block the growth of human retinal endothelial cells and antiangiogenic activity in vitro. The isoflavonoids 5 and 6, and the pterocarpans 1, 2, 4, 20, and 22 demonstrated selective antiproliferative activities on endothelial cells compared to a nonendothelial cell type, with concentration-dependent antiangiogenic effects in vitro against HRECs, a cell type relevant to neovascular eye diseases.

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Hepatoprotective activity of Erythrina × neillii leaf extract and characterization of its phytoconstituents

Cited by 10 publications

References 30 publications

Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of Bignonia binata leaves against carbon tetrachloride-induced injury in rats

Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon

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Hepatoprotective activity of Erythrina × neillii leaf extract and characterization of its phytoconstituents

Cited by 10 publications

References 30 publications

Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

Metabolomic study of the estrogenic and anti‐osteoporotic potential of Erythrina bidwillii leaf

LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of Bignonia binata leaves against carbon tetrachloride-induced injury in rats

Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon

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Hepatoprotective activity of Erythrina × neillii leaf extract and characterization of its phytoconstituents