Hepatoprotective activity of cultured mycelium of Morel mushroom, Morchella esculenta

Nitha, B; Fijesh, P. V.; Janardhanan, K. K.

doi:10.1016/j.etp.2011.06.007

Cited by 67 publications

(37 citation statements)

References 28 publications

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“…Since commercial cultivation of this mushroom has not been successful till now, its cultured mycelium is extensively used as a flavouring agent. Recently, it has been proven that morel possess anti-inflammatory, antitumor, antioxidant and antimicrobial activities (Mau, Chang, Huang, & Chen, 2004;Nitha, Meera, & Janardhanan, 2007;Nitha and Janardhanan, 2008;Nitha, Fijesh, & Janardhanan, 2011;Alves et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia

Heleno

Stojković

Barros³

et al. 2013

Food Research International

101

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A comparative study on chemical composition (nutritional value, primary and secondary metabolites), antioxidant properties (scavenging activity, reducing power and inhibition of lipid peroxidation), and antimicrobial activity (antibacterial and demelanizing properties) of two samples of Morchella esculenta (morel) from different countries (Portugal and Serbia) was performed. This species was chosen for being one of the most highly prized edible mushrooms in the world. Both samples are rich in carbohydrates (including free sugars) and proteins, and contain several bioactive compounds such as organic acids, phenolic compounds and tocopherols.Polyunsaturated fatty acids were the most abundant compounds followed by mono or saturated fatty acids. Sample from Portugal (SP) gave higher radical scavenging activity and reducing power, while sample from Serbia (SS) showed higher lipid peroxidation inhibition. Both samples gave antibacterial activity against five bacteria (in some cases even better than standard antibiotics) and demelanizing activity against four micromycetes, showing SS higher activities. As far as we know, this is the first study reporting chemical compounds and bioactivity of morel samples from Portugal and Serbia. Furthermore, a novel method for evaluation of demelanizing activity was presented.

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Section: Introductionmentioning

confidence: 99%

A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia

Heleno

Stojković

Barros³

et al. 2013

Food Research International

101

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“…The extracts of wild Suillus bellinii showed high reducing power, scavenging DPPH radicals capacity, and high antiproliferative activity against MCF7, NCI-H460 and HepG2 cells [12]. The aqueous-ethanolic extract of M. esculenta mycelium showed hepatoprotective activity in vivo [13]. Phenolic extracts of Ganoderma lucidum fruiting body even showed higher antioxidant capacity than its polysaccharidic extracts [14].…”

Section: Introductionmentioning

confidence: 99%

Cellular Antioxidant and Antiproliferative Activities of Morchella conica Pers. Polyphenols in vitro

Xia¹,

Li²,

Tan³

et al. 2017

JFNR

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This study analyzed the cellular antioxidant and antiproliferative activities, as well as the phenolic composition of three Morchella conica Pers. cultures. Results showed that the free phenolic contents of the three Morchella conica Pers. ranged from 4.928 to 6.157 mg GAE/g DW and their bound phenolic contents ranged from 0.188 to 0.250 mg GAE/g DW. Polyphenols in M. conica Pers. were dominated by phenolic acids, particularly for gallic acid. The free phenolic extracts exhibited higher cellular antioxidant activity than the bound phenolic extracts. Free phenolics in M. conica Pers. cultured from Yunnan China showed the highest antiproliferative activity against HepG 2 cells, whereas bound phenolics in M. conica cultured from Tibet China showed the highest antiproliferative activity. Results confirmed that Morchella conica Pers. (growing in Yunnan China especially) could be a new source of natural antioxidant and a potential inhibitor for the growth of HepG 2 cells.

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“…Since commercial cultivation of this mushroom has not been successful till now, its cultured mycelium is extensively used as a flavoring agent. Recently, it has been proven that morel possess anti-inflammatory, antitumor, antioxidant and antimicrobial activities, as well as demelanizing properties on microfungi (Mau et al 2004;Nitha et al, 2007Nitha et al, , 2013Nitha & Janardhanan 2008;Alves et al 2012;Heleno et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of antimutagenic and antimitotic effects ofMorchella esculentaextracts and protocatechuic acid

Stojković

Davidović

Živković

et al. 2013

Frontiers in Life Science

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Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his + revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound -protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.

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Hepatoprotective activity of cultured mycelium of Morel mushroom, Morchella esculenta

Cited by 67 publications

References 28 publications

A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia

A comparative study of chemical composition, antioxidant and antimicrobial properties of Morchella esculenta (L.) Pers. from Portugal and Serbia

Cellular Antioxidant and Antiproliferative Activities of <i>Morchella conica</i> Pers. Polyphenols <i>in</i> <i>vitro</i>

Comparative evaluation of antimutagenic and antimitotic effects ofMorchella esculentaextracts and protocatechuic acid

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