Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats

Santhosh, Sethumadhavan; Sini, Theruvathil K.; Anandan, R.; Mathew, P. M.

doi:10.1016/j.ejphar.2007.05.059

Cited by 87 publications

(62 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…INH and RMP were given daily for 14 days to produce liver toxicity at very high doses (INH 50 mg/kg, RMP 100 mg/kg) as compared with humans because rats metabolize drugs faster than humans and period of study shorter in comparison to the treatment of TB in humans. 44 At day 15 th after the last dose administration hepatic injury was assessed by the measurement of liver enzymes (ALT, AST, ALP, and Bilirubin) and the presence of microscopic fi ndings.…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Kamil¹,

Imran-ul-Haque²

2014

Phcog J.

View full text Add to dashboard Cite

Objective: In this study anti-tubercular (Anti-TB) drugs (isoniazid [INH] and rifampicin [RMP]) induced liver toxicity has been studied for the hepatoprotective effect of hydroethanolic extract of Calotropis procera (CP) fl owers in rats. Materials and Methods: Animals were divided into four groups, group A was given normal saline (1 ml/kg), group B received INH (50 mg/kg) and RMP (100 mg/kg) group C received INH (50 mg/kg), RMP (100 mg/kg) and CP (150 mg/kg) orally for 14 days. Results: Biochemical markers of liver toxicity such as aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin and tissue histology were done inall groups. Anti-TB drugs (INH 50 mg/kg and RMP 100 mg/kg) have enhanced the ALT, AST, ALP, bilirubin and histological changes in liver, whereas co-administration of anti-TB drugs with CP has reduced these levels within the normal range. Conclusion: Findings of this study showed the hepatoprotective effect of CP against INH and RMP administration to reduce the liver damage for chronic treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Kamil¹,

Imran-ul-Haque²

2014

Phcog J.

View full text Add to dashboard Cite

show abstract

“…The study involved inducing hepatotoxicity in laboratory rats by using anti-tubercular drugs in different combination (Santhosh et al, 2007;Saraswathy et al, 1998), and then evaluating the effect of different preparations on hepatic markers.…”

Section: Principlementioning

confidence: 99%

Hepatoprotective effects of methanol extract of Alchornea cordifolia leaves against anti-tubercular drugs induced hepatotoxicity in rats

Etienne¹,

Landry²,

Genevieve³

et al. 2017

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Alchornea cordifolia has been shown to be hepatoprotective against hepatotoxicity induced by high dose paracetamol in a model animal. However, its hepatoprotective effects against the hepatotoxicity induced by anti-tubercular drugs have not yet been studied, whereas anti-tubercular drugs are known to be hepatotoxic at therapeutic dose. The aim of this work was to evaluate the hepatoprotective effect of a methanol extract of A. cordifolia leaves in order to overcome hepatotoxicity induced by antitubercular drugs. Isoniazid, Rifampicin and Pyrazinamid have been used to induce hepatotoxicity in rats. The animals were administered hepatotoxic agent. Two hours later they were given methanol extract of A. cordifolia (MEAC) leaves or silymarin. One group of animals received only the antitubercular drugs, one group received MEAC only and another group received physiological saline. The animals were thus treated for 10 consecutive days. Blood sample was taken on the 11th day for evaluation of the biochemical parameters, as well as markers of hepatotoxicity. Isoniazid increased transaminases (ALT and AST), MEAC and silymarin reduced these biochemical parameters, Isoniazid + Rifampicin increased ALT and AST levels, MEAC reduced alanine transaminase (ALT) and aspartate transaminase (AST) levels, Isoniazid + Rifampicin + Pyrazinamid combination resulted in significant ALT elevation and MEAC reduced the ALT levels. MEAC alone did not significantly alter ALT and AST values. Phytochemical screening revealed the presence of flavonoids, polyphenols, saponosides and alkaloids. A. cordifolia leaves would thus have a protective effect against anti-tubercular drugs induced hepatotoxicity in rats.

show abstract

“…In addition, hepatocellular damage leads a reduction in albumin accompanied by a relative increase in globulins, which decrease A/G ratio (Santhosh et al 2007). In hepatotoxic conditions, a significant reduction in serum urea was detected due the failure of the liver in converting amino acids and ammonia into urea (Reichen and Paumgartner 1980).…”

Section: Safety Use Of Extract Of Spondias Tuberosa 2001mentioning

confidence: 99%

Acute Toxicity and Cytotoxicity Effect of Ethanolic Extract of Spondias tuberosa Arruda Bark: Hematological, Biochemical and Histopathological Evaluation

BARBOSA

Nascimento

Araújo

et al. 2016

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb 300 ) or 2.000mg/kg body weight (ESStb 2.000 ) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb 300 nor EEStb 2.000 produced mortality nor changes in body weight during the 14-days of observation, but EEStb 2.000 reduced quietly the food and water intake as well as locomotor activity at first day. There were no changes in macroscopic, histopathological, biochemical and hematological parameters. EEStb in concentrations of 6.25-50μg ml −1 on HEp-2 cell did not produce cytotoxic effect. These results suggest that EEStb did not cause acute toxicity and cytotoxic, suggesting a good safety rate for Spondias tuberosa Arruda.

show abstract

Hepatoprotective activity of chitosan against isoniazid and rifampicin-induced toxicity in experimental rats

Cited by 87 publications

References 23 publications

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity

Hepatoprotective effects of methanol extract of Alchornea cordifolia leaves against anti-tubercular drugs induced hepatotoxicity in rats

Acute Toxicity and Cytotoxicity Effect of Ethanolic Extract of Spondias tuberosa Arruda Bark: Hematological, Biochemical and Histopathological Evaluation

Contact Info

Product

Resources

About