Hepatoprotective Action of Zerumbone Against Paracetamol Induced Hepatotoxicity

Fakurazi, Sharida; Ithnin, Hairuszah; Lip, J. Mohd; Shanthi, G.; Nanthini, Uma; Shamima, A. R.; Roslida, H.; Tan, Yu-fen

doi:10.3923/jms.2009.161.164

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…Zerumbone also caused lowering of glutathione concentration in hepatic tissues and PCNA expression in rat liver sections. Furthermore, in line with the previous findings on the effect of the sesquiterpene on Bax and Bcl-2 proteins, Abdul Prevented necrosis of liver tissues after administration of overdosage of paracetamol [75,76] Abbreviations used: AAF, 2-acetylaminofluorene; AFP, alpha-fetoprotein; AgNORs, argyrophilic nucleolar organizer region associated proteins; ALT, alanine transaminase; AOM, azoxymethane; AST, aspartate transaminase; ALP, alkaline phosphatase; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; CCK, cholecystokinin octapeptide; COX, cyclooxygenase; Cu, copper; DEN, diethylnitrosamine; DES, diethylstilboestrol; DSS, dextran sodium sulfate; GSH, glutathione; GST, glutathione S-transferase; HO, hemeoxygenase; ICR, Institute for Cancer Research; IkBa, IkappaBalpha; IL, interleukin; MIA, monosodium iodoacetate; iNOS; inducible NO synthase; Mn, manganese; NFkB, nuclear factor kappa B; NNK, nicotine-derived nitrosamine ketone; PCNA, proliferating cell nuclear antigen; PGE 2 , prostaglandin E2; TNF-a, tumor necrosis factor-alpha; Zn, zinc. and co-workers observed that zerumbone can induce increase in Bax protein and decrease in Bcl-2 protein expression in the rat liver.…”

Section: In Vivo Anti-cancer Effects Of Zerumbonesupporting

confidence: 90%

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Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Prasannan

Kalesh

Shanmugam

et al. 2012

Biochemical Pharmacology

126

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Section: In Vivo Anti-cancer Effects Of Zerumbonesupporting

confidence: 90%

“…For instance, zerumbone was reported to reduce overdosage of paracetamol-induced inflammation of liver tissues in male Sprague-Dawley rats [75]. Zerumbone was also found to prevent necrosis of the rat liver tissues.…”

Section: In Vivo Anti-cancer Effects Of Zerumbonementioning

confidence: 99%

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Prasannan

Kalesh

Shanmugam

et al. 2012

Biochemical Pharmacology

126

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“…Essential oils extracted from Zingiber zerumbet rhizomes have potential pharmacological activities, including antimicrobial, anti-inflammatory, chemo-preventive, antinociceptive, antiulcer, antioxidant, antipyretic and analgesic, as previously described [ 3 – 7 ]. The major bioactive molecule found in the essential oil of Zingiber zerumbet rhizomes is the zerumbone (Fig.…”

Section: Introductionmentioning

confidence: 99%

Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans

Silva

Pinheiro

Orlandi

et al. 2018

BMC Complement Altern Med

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BackgroundEssential oil obtained from rhizomes of the Zingiber zerumbet (L.) Smith (popularly known in Brazil as bitter ginger) is mainly constituted by the biomolecule zerumbone, which exhibit untapped antimicrobial potential. The aim of this study was to investigate the antimicrobial activity of the zerumbone from bitter ginger rhizomes against the cariogenic agent Streptococcus mutans.MethodsFirstly, the essential oil from rhizomes of Zingiber zerumbet (L.) Smith extracted by hydrodistillation was submitted to purification and recrystallization process to obtain the zerumbone compound. The purity of zerumbone was determined through high-performance liquid chromatography analysis. Different concentrations of zerumbone were tested against the standard strain S. mutans (ATCC 35668) by using microdilution method. The speed of cidal activity was determined through a time kill-curve assay. The biological cytotoxicity activity of zerumbone was assessed using Vero cell line through MTT assay.ResultsThe zerumbone showed a minimum inhibitory concentration (MIC) of 250 μg/mL and a minimum bactericidal concentration (MBC) of 500 μg/mL against S. mutans. After six hours of bacteria-zerumbone interaction, all concentrations tested starts to kill the bacteria and all bacteria were killed between 48 and 72 h period at the concentration of 500 μg/mL (99,99% of bacteria were killed in comparison with original inoculum). In addition, zerumbone showed no cytotoxicity activity on mammalian continuous cells line.ConclusionsThese results draw attention to the potential of zerumbone as antimicrobial agent against S. mutans infection, indicating its possible use in the phyto-pharmaceutical formulations as new approach to prevent and treat tooth decay disease.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2360-0) contains supplementary material, which is available to authorized users.

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“…Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oil of rhizomes from wild ginger, Zingiber zerumbet [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Zerumbone has been shown to possess strong antitumor [ 27 , 30 , 39 ], antioxidant [ 40 ], antimicrobial [ 41 ], anti-nociceptive [ 42 ], hepatoprotective [ 43 ], immunomodulatory [ 44 ], anti-inflammatory [ 33 , 45 , 46 ], and gastro-protective [ 40 ] activity. However, despite promising in-vitro and in-vivo studies demonstrating the therapeutic utility of zerumbone, its preclinical and clinical development has been limited due to its poor water solubility, poor absorption, or low bioavailability, limiting its targeting into various tissues and organs of interest.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone

Kesharwani

Bhat

2020

Medicina

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About 40–70% of drug molecules in the clinical development pipeline suffer from one of either low aqueous solubility, poor absorption, or extremely low bioavailability. Approximately 75% of the world population relies on traditional therapies and therefore there has been a growing interest in the utilization of natural compounds. Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oils of rhizomes from Zingiber zerumbet. It possesses strong antitumor, antioxidant, antimicrobial, and anti-inflammatory activity. However, despite promising preclinical studies demonstrating the therapeutic utility of zerumbone, its clinical development has been limited due to its low aqueous solubility, poor absorption, or associated low bioavailability. Multiple reviews demonstrating the pharmacological effects of zerumbone for various diseases have been published. However, to our knowledge, no review demonstrates the various formulation strategies developed to overcome the biopharmaceutical challenges of zerumbone. The purpose of this review is to provide a comprehensive perspective on zerumbone as a molecule for formulation development. A section related to pharmacokinetics, toxicity, and patents of zerumbone is included. This review provides the importance of developing novel formulations of zerumbone to overcome its biopharmaceutical challenges thereby advance its potential in the treatment of various diseases.

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Hepatoprotective Action of Zerumbone Against Paracetamol Induced Hepatotoxicity

Cited by 12 publications

References 17 publications

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

Zerumbone from Zingiber zerumbet (L.) smith: a potential prophylactic and therapeutic agent against the cariogenic bacterium Streptococcus mutans

Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone

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