Hepatoprotection via the IL-6/Stat3 pathway

Resolution of inflammation-related apoptotic processes by the synthetic tellurium compound, AS101 following liver injury

“…The pleiotrophic cytokine, IL-6 has been known for its beneficial hepatoprotective functions. Regeneration of liver parenchyma following immune related injury is controlled by IL-6 through Stat3 signaling [40,41]. These ligands initiate immediate induction of early genes such as c-fos, c-jun, and c-myc, which stimulate hepatocytes to enter the cell cycle [42].…”

Protective Effects of Calycosin Against CCl4-Induced Liver Injury with Activation of FXR and STAT3 in Mice

“…STAT3 is activated by various cytokines and growth factors which are interleukin-6 (IL-6), leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) (14,15). Investigations revealed that STAT3 has positive properties of promoting liver regeneration, maintaining carbohydrate and lipid homeostasis (16,17).…”

Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression

“…It is considered a hepatoprotective factor by stimulating hepatocyte proliferation through activation of Stat-3 and MAPK signaling pathways [3,4]. In addition, IL-6 attenuates hepatocyte apoptosis by maintaining adequate levels of several anti-apoptotic factors [5].…”