Hepatoprotection by dandelion (<i>Taraxacum officinale</i>) and mechanisms

Mahboubi, Mohaddese; Mahboubi, Mona

doi:10.4103/2221-1691.273081

Cited by 29 publications

(21 citation statements)

References 5 publications

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“…In MS/MS spectrum this compound showed a characteristic fragment at 285, may be due to successive removal of hexosyl (loss of 162) + rhamnosyl (loss of 146) moieties from parent ion. Therefore, metabolite (15) was tentatively identified as isovitexin-3"-O-glucopyranoside. Compound (16) (eluting at retention time = 9.66 min) exhibited deprotonated [M − H] − ion at m/z 447.…”

Section: Metabolite Fingerprintingmentioning

confidence: 99%

“…T. officinale is used in traditional medicinal system to cure hepatic disorders due to its antioxidant and anti-inflammatory properties. The T. officinale is reported to reduce lipid accumulation and liver inflammation which may be vital factors in improving the liver function [15]. It has been reported that T. officinale roots and leaves induced hypolipidemic impact in high cholesterol diet fed rabbits by improving plasma antioxidant concentration which ultimately lead to prevention of oxidative stress related atherosclerosis [16].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Obesity Attributes; UHPLC-QTOF-MS/MS-Based Metabolite Profiling and Molecular Docking Insights of Taraxacum officinale

et al. 2020

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The naturopathic treatment of obesity is a matter of keen interest to develop efficient natural pharmacological routes for disease management with low or negligible toxicity and side effects. For this purpose, optimized ultrasonicated hydroethanolic extracts of Taraxacum officinale were evaluated for antiobesity attributes. The 2,2-diphenyl-1-picrylhydrazyl method was adopted to evaluate antioxidant potential. Porcine pancreatic lipase inhibitory assay was conducted to assess the in vitro antiobesity property. Ultra-high performance chromatography equipped with a mass spectrometer was utilized to profile the secondary metabolites in the most potent extract. The 60% ethanolic extract exhibited highest extract yield (25.05 ± 0.07%), total phenolic contents (123.42 ± 0.007 mg GAE/g DE), total flavonoid contents (55.81 ± 0.004 RE/g DE), DPPH-radical-scavenging activity (IC50 = 81.05 ± 0.96 µg/mL) and pancreatic lipase inhibitory properties (IC50 = 146.49 ± 4.24 µg/mL). The targeted metabolite fingerprinting highlighted the presence of high-value secondary metabolites. Molecular-binding energies computed by docking tool revealed the possible contribution towards pancreatic lipase inhibitory properties of secondary metabolites including myricetin, isomangiferin, icariside B4, kaempferol and luteolin derivatives when compared to the standard drug orlistat. In vivo investigations revealed a positive impact on the lipid profile and obesity biomarkers of obese mice. The study presents Taraxacum officinale as a potent source of functional bioactive ingredients to impart new insights into the existing pool of knowledge of naturopathic approaches towards obesity management.

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Section: Metabolite Fingerprintingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Obesity Attributes; UHPLC-QTOF-MS/MS-Based Metabolite Profiling and Molecular Docking Insights of Taraxacum officinale

et al. 2020

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“…Different parts of dandelion plants are being studied for both nutritional and chemical values [ 119 ]. Apart from being used as a therapeutic agent, the leaves, roots, and petals of the dandelion plant are used in different food products [ 120 ]. For example, the leaves are eaten as a salad in Vietnam and France, either alone or in combination with other plants, such as chives and lettuce [ 121 ].…”

Section: Types Of Prebioticsmentioning

confidence: 99%

Plant Prebiotics and Their Role in the Amelioration of Diseases

et al. 2021

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Prebiotics are either natural or synthetic non-digestible (non-)carbohydrate substances that boost the proliferation of gut microbes. Undigested fructooligosaccharides in the large intestine are utilised by the beneficial microorganisms for the synthesis of short-chain fatty acids for their own growth. Although various food products are now recognized as having prebiotic properties, several others, such as almonds, artichoke, barley, chia seeds, chicory, dandelion greens, flaxseeds, garlic, and oats, are being explored and used as functional foods. Considering the benefits of these prebiotics in mineral absorption, metabolite production, gut microbiota modulation, and in various diseases such as diabetes, allergy, metabolic disorders, and necrotising enterocolitis, increasing attention has been focused on their applications in both food and pharmaceutical industries, although some of these food products are actually used as food supplements. This review aims to highlight the potential and need of these prebiotics in the diet and also discusses data related to the distinct types, sources, modes of action, and health benefits.

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“…Taraxacum officinale is known for a long time and the secretion used pepsin and hydrochloric acid in the stomach, and secondary influencing also for bile secretion. Abused is also a liver disease in the treatment of cirrhosis liver and after viral inflammation liver [Ezhilarasan 2016, Mahboubi andMahboubi 2020]. The hepatoprotective effect of dandelion extract (0.5 mg/ml) was confirmed by histopathological examination.…”

Section: Healing Propertiesmentioning

confidence: 99%