Hepatoid Adenocarcinoma of the Lung: A Case Report and Literature Review

Mokrim, Maha; Belbaraka, Rhizlane; Allaoui, Mohamed; Kairaouani, Mouna; Mahassini, N.; Tahri, A.; Errihani, Hassan

doi:10.1007/s12029-011-9318-5

Cited by 24 publications

(11 citation statements)

References 12 publications

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“…Although CT images were only provided in 7 cases in the literature review (2,9,11,16), in addition to the present case, certain information was also obtained indirectly from a description of CT features and/or pathological specimens (11 cases). These data indicated the following findings.…”

Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Sun

Zhang

et al. 2016

Oncology Letters

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Abstract. Hepatoid adenocarcinoma of the lung (HAL) is a rare type of extrahepatic hepatoid adenocarcinoma. The majority of such cases that have been reported in the English literature have demonstrated elevated serum α-fetoprotein (AFP) and/or positive AFP expression on histopathological analysis, and have had poor prognoses. The current study reports an extremely rare case of HAL in the right upper lung without AFP production in a 59-year-old male patient. The patient underwent radical right upper lobectomy via video assisted thoracoscopic surgery. No signs of local recurrence or distant metastasis have been observed for 23 months after the surgery. The serum AFP level following surgery remained within the normal range. Although the diagnosis of HAL predominantly depends on pathological examination, a review of the literature demonstrates that HAL has certain characteristic features with regard to its clinical and computed tomography findings and prognoses, and clinicians should be aware that clinicians should be aware that monitoring serum AFP levels, as well as CT findings, remains important.

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Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Sun

Zhang

et al. 2016

Oncology Letters

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“…In the English literature, there are 14 cases of primary pulmonary hepatoid carcinoma and hepatoid adenocarcinoma without liver metastasis [1–4,7,9–12] (Table 1). All cases reported were male, with ages ranged from 35 to 82 years (mean age: 60 years).…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary hepatoid carcinoma: Report of a case and review of the literature

Lin

Hsu

Chou

2013

The Kaohsiung J of Med Scie

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Hepatoid carcinoma is a rare malignancy defined as extrahepatic primary alpha-fetoprotein-producing carcinoma morphologically resembling hepatocellular carcinoma. It is extremely rare in the lungs, with ambiguous pathological descriptions and variable prognosis. Herein, we present the case of a 66-year-old man with a primary pulmonary hepatoid carcinoma in his right upper lung who received complete curative surgical resection and adjuvant chemotherapy. No signs of recurrence or distant metastasis have been observed for 57 months postoperation. In addition, the literature is reviewed and the pathological diagnostic pitfalls are discussed.

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“…Hepatoid adenocarcinoma of the lung is a rare subtype of lung carcinoma, and only 22 cases have been reported in the full-text English literature. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Ishikura et al, 20 first reported a hepatoid adenocarcinoma of the lung and proposed the following two diagnostic criteria: (i) presence of typical acinar or papillary adenocarcinoma, and (ii) presence of a carcinoma component which resembles hepatocellular carcinoma and produces AFP. However, only 12 out of 23 (52.2%) hitherto described cases exhibited high serum AFP levels (>10 ng/ml).…”

Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the lung mimicking metastatic hepatocellular carcinoma

et al. 2020

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Hepatoid Adenocarcinoma of the Lung: A Case Report and Literature Review

Cited by 24 publications

References 12 publications

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Primary pulmonary hepatoid carcinoma: Report of a case and review of the literature

Hepatoid adenocarcinoma of the lung mimicking metastatic hepatocellular carcinoma

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