Hepatoid adenocarcinoma of the lung mimicking metastatic hepatocellular carcinoma

Miyama, Yu; Fujii, Takeshi; Murase, Kyoko; Takaya, Hisashi; Kondo, Fukuo

doi:10.4322/acr.2020.162

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…Hepatoid adenocarcinoma is a rare extrahepatic tumor. Its morphological characteristics are similar to those of hepatocellular carcinoma[ 6 ]. About 5% of the primary sites are in the lungs[ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the lung: A case report

Mo,

Lin,

Tao

et al. 2024

World J Clin Cases

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BACKGROUND Hepatoid adenocarcinoma of the lung (HAL) is a rare type of non-small cell lung cancer (NSCLC), histologically similar to hepatocellular carcinoma. HAL has high malignancy and poor prognosis, and a better treatment plan needs further study. CASE SUMMARY In order to deeply understand the occurrence and development of HAL, here we report a case of HAL with extensive metastasis of alpha fetoprotein negative KRAS A146T mutation. The patient refused chemotherapy and received one course of treatment (immune checkpoint inhibitors), and died three months later due to progressive disease. CONCLUSION HAL is a special type of NSCLC. The surgical treatment of HAL in the limited stage can achieve long-term survival, but most of them were in the advanced stage when they were found, and the prognosis was poor, which requires multidisciplinary comprehensive treatment.

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Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the lung: A case report

Mo,

Lin,

Tao

et al. 2024

World J Clin Cases

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“…Despite advances in HCV treatment, the true impact is predicated to be a meek decrease of 10-15% of HCC. This is because many patients with HCV remain undiagnosed and the treatment is not accessible to those of lower socioeconomic status [1]. Meanwhile, worldwide vaccination against HBV has demonstrated to reduce the incidence of HCC as well as the use of lamivudine [2].…”

Section: Discussionmentioning

confidence: 99%

“…Hepatocellular carcinoma (HCC) is the most common (>80%) primary liver malignancy worldwide and 80% of HCC cases arise in cirrhosis [1]. Hepatocellular carcinoma is the sixth most common malignancy and the fourth most common cause of cancer mortality worldwide [2].…”

Section: Introductionmentioning

confidence: 99%

Rare Presentation of Metastatic Hepatocellular Carcinoma to The Finger, Case report and Review of the literature

Gabra¹

2023

JOJDC

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Hepatocellular carcinoma (HCC) is a primary tumor of the liver that develops in the setting of chronic liver disease. HCC is difficult to diagnosis due to it requiring the use of multiple imaging modalities with the goal to detect tumors when they are less than or equal to 2 cm in size to allow all possible treatment options to be used. Herein, we discuss a 69-year-old male with stage IV liver cancer residing in hospice presenting with left middle finger osteomyelitis and extreme pain. Radiology revealed a destructive lesion, but pathology provided the diagnosis of metastatic hepatocellular carcinoma in his finger. Even though HCC can be diagnosed on imaging alone, this case highlights the need for biopsy to provide an accurate diagnosis

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“…Иммуногистохимическое исследование опухоли показало положительную реакцию на АФП в 31 (60,8 %) из 51 случая, а 21 (41,1 %) из 51 случая были отрицательными на АФП. В нашем случае мы не выявили продукцию АФП опухолевыми клетками, что подтверждено дважды [10].…”

Section: Discussionunclassified

Rare case of primary hepatoid adenocarcinoma of the lung

et al. 2022

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Hepatoid adenocarcinoma is a rare type of adenocarcinoma with hepatocellular differention, which is characterized by early metastatic spread and poor prognosis. The treatment strategy in not clearly defined due to an extreme rarity of the tumor. Surgery is the most effective tool as a part of multimodality concept. So far, only 51 cases have been described in the literature, and only one in Russia.Clinical case description. We report a case of metastatic hepatoid adenocarcinoma of the lung in a 54-year-old male patient. The difficulties in morphologic differential diagnosis between adenocarcinoma of the lung and primary liver cancer were described. The strategy for managing patients with hepatoid adenocarcinoma of the lung was demonstrated.Conclusion. Hepatoid adenocarcinoma of the lung is a rare tumor with unfavourable outcome.

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Hepatoid adenocarcinoma of the lung mimicking metastatic hepatocellular carcinoma

Cited by 9 publications

References 24 publications

Hepatoid adenocarcinoma of the lung: A case report

Hepatoid adenocarcinoma of the lung: A case report

Rare Presentation of Metastatic Hepatocellular Carcinoma to The Finger, Case report and Review of the literature

Rare case of primary hepatoid adenocarcinoma of the lung

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